Protein Alignment SPoCk and SERCA

DIOPT Version :9

• Sequence 1: NP_001262220.1
• Gene: SPoCk / 40495
• FlyBaseID: FBgn0052451
• Length: 1062
• Species: Drosophila melanogaster
• Sequence 2: NP_726381.1
• Gene: SERCA / 49297
• FlyBaseID: FBgn0263006
• Length: 1020
• Species: Drosophila melanogaster
• Alignment Length: 1042
• Identity: 314/1042 - (30%)
• Similarity: 495/1042 - (47%)
• Gaps: 192/1042 - (18%)

  Fly   126 DVRTGLKWTEAKYRAKIIGHNELLLVAEDPTWKKYIEQFRNPLILLLLGSALVSVIMKQFDD--- 187
            |...||...:.|...|..|.|||........|:..:|||.:.|:.:||.:|::|.::..|::
  Fly    19 DPERGLTLDQIKANQKKYGPNELPTEEGKSIWQLVLEQFDDLLVKILLLAAIISFVLALFEEHEE 83

  Fly   188 ----AVSITIAILIVVTVAFI---QEYRSEKSLEELKKLVPPECHCLREGR--LDTFLARELVPG 243
                .|...:.:||::..|.:   ||..:|.::|.||:..|.....:|:.:  :....|:|:|||
  Fly    84 TFTAFVEPLVILLILIANAVVGVWQERNAESAIEALKEYEPEMGKVVRQDKSGIQKVRAKEIVPG 148

  Fly   244 DIVHLNVGDRVPADVRL--FEAVDLSIDESSFTGETEPARKITDVLLNNTNVKDHSNMKNIAFMG 306
            |:|.::|||::|||:|:  ..:..|.||:|..|||:....|.||.:.:...|  :.:.|||.|.|
  Fly   149 DLVEVSVGDKIPADIRITHIYSTTLRIDQSILTGESVSVIKHTDAIPDPRAV--NQDKKNILFSG 211

  Fly   307 TLVRCGNGKGIVVSTGERSEFGEVFKMMQAEEAPKTPLQKSMDILGAQLSFYSFLIIGVIMLL-- 369
            |.|..|..:|:|:.||..:..|::...|...|..|||||:.:|..|.|||    .:|.||.:.
  Fly   212 TNVAAGKARGVVIGTGLSTAIGKIRTEMSETEEIKTPLQQKLDEFGEQLS----KVISVICVAVW 272

  Fly   370 --------------GWLQGKPLSEMFNISVSLAVAAIPEGLPIVVTVTLALGVMRMAKRNSIVKK 420
                          .|::|  ....|.|:|:|||||||||||.|:|..||||..||||:|:||:.
  Fly   273 AINIGHFNDPAHGGSWIKG--AIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRS 335

  Fly   421 LPTVETLGCVNVICSDKTGTLTKNEMTATIIITSDGYMA--------DVTGAGYNDQGEIHIRHC 477
            ||:||||||.:|||||||||||.|:|:.:.:...|....        ::||:.|...||:.:
  Fly   336 LPSVETLGCTSVICSDKTGTLTTNQMSVSRMFIFDKVEGNDSSFLEFEMTGSTYEPIGEVFL--- 397

  Fly   478 NNVEMAKTNITNLLEIGAVC---------NNAYIQNGTLLGQPTEGALVAVAMKNGMYATAEN-- 531
            |...:...:...|.|:..:|         .|.:.|....:|:.||.||:.:|.|...::..::
  Fly   398 NGQRIKAADYDTLQELSTICIMCNDSAIDYNEFKQAFEKVGEATETALIVLAEKLNSFSVNKSGL 462

  Fly   532 ----------------YVRIQEYPFSSEQKMMAVKC--IHKYNNNKEEIFFAKGALETLLPQCTK 578
                            :.:.....||.::|.|:..|  :...........|.|||.|.:|.:||.
  Fly   463 DRRSAAIACRGEIETKWKKEFTLEFSRDRKSMSSYCTPLKASRLGTGPKLFVKGAPEGVLERCTH 527

  Fly   579 YQFGTQTVPLTKQNEAEFLA--EAYEIGRKGLRVLALAKGRSMQ------------------DLI 623
            .:.||..||||...:|:.||  ..|..||..||.||||...|..                  :|.
  Fly   528 ARVGTTKVPLTSALKAKILALTGQYGTGRDTLRCLALAVADSPMKPDEMDLGDSTKFYQYEVNLT 592

  Fly   624 YCGLVGITDPPRPLVRESIEMLMQSGVRVKMVTGDAQETALAIDPSRRLQAVPTHAIPAWPTAGG 688
            :.|:||:.||||..|.:||.....:|:||.::|||.:.||.||  .||
  Fly   593 FVGVVGMLDPPRKEVFDSIVRCRAAGIRVIVITGDNKATAEAI--CRR----------------- 638

  Fly   689 VPLCSASACCSTNCLENAMKEIYLTALAQQGLPLVTANLIGI-----DTIHHQTLSGQEMDQMNE 748
                                                   ||:     ||. .::.||:|.|.::.
  Fly   639 ---------------------------------------IGVFAEDEDTT-GKSYSGREFDDLSP 663

  Fly   749 HQLDKVANNVSVFYRVSPRHKLEIVKSLQRSGNIVGMTGDGVNDGVALKKADIGIAMGKNGTDVC 813
            .:.........:|.||.|:||.:||:.||....|..||||||||..|||||:|||||| :||.|.
  Fly   664 TEQKAAVARSRLFSRVEPQHKSKIVEFLQSMNEISAMTGDGVNDAPALKKAEIGIAMG-SGTAVA 727

  Fly   814 KEAADMILVNDDFHTIIAAIEEGKGIFYNIRNFVRFQLSTSIAALALIALATLMDIANPLNAMQI 878
            |.||:|:|.:|:|.:|::|:|||:.|:.|::.|:|:.:|::|..:..|.|...:.:...|..:|:
  Fly   728 KSAAEMVLADDNFSSIVSAVEEGRAIYNNMKQFIRYLISSNIGEVVSIFLTAALGLPEALIPVQL 792

  Fly   879 LWINIIMDGPPAQSLGVEPVDHDVLKQKPRNVKQPMIT-----KSVVVNVLLSASIIVLGTLW-V 937
            ||:|::.||.||.:||..|.|.|::::.||...:.:|:     :.:.:...:.|:.:.....| |
  Fly   793 LWVNLVTDGLPATALGFNPPDLDIMEKPPRKADEGLISGWLFFRYMAIGFYVGAATVGAAAWWFV 857

  Fly   938 FQRE-----------------------MADGTLGKTKRDTTMTFTCFVFFDMFNALSCRSQTKSV 979
            |..|                       ..|..:.......||..:..|..:|.||::..|:.:|:
  Fly   858 FSDEGPKLSYWQLTHHLSCLGGGDEFKGVDCKIFSDPHAMTMALSVLVTIEMLNAMNSLSENQSL 922

  Fly   980 FTIGLTTNRMFLLAVAFSIIGQMLVVYFPPLQMVFQTEALTPYDIFFLVSLTSSVLVVSEIKKWF 1044
            .|:....|...:.::|.|.....:::|...|..|||...|:..:...::..:..|:::.|..|:.
  Fly   923 ITMPPWCNLWLIGSMALSFTLHFVILYVDVLSTVFQVTPLSAEEWITVMKFSIPVVLLDETLKFV 987

  Fly  1045 ER 1046
            .|
  Fly   988 AR 989

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SPoCk	NP_001262220.1	ATPase-IIA2_Ca	110..1049	CDD:130585	314/1042 (30%)
		Cation_ATPase_N	112..179	CDD:279080	17/52 (33%)
		E1-E2_ATPase	191..425	CDD:278548	95/256 (37%)
		Cation_ATPase	496..579	CDD:289987	23/111 (21%)
		COG4087	<760..823	CDD:226572	38/62 (61%)
		Cation_ATPase_C	872..1044	CDD:279079	44/200 (22%)
SERCA	NP_726381.1	P-type_ATPase_SERCA	5..989	CDD:319778	313/1040 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438612
Domainoid	1	1.000	100	1.000	Domainoid score	I354
eggNOG	1	0.900	-	-		E2759_KOG0202
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D100699at2759
OrthoFinder	1	1.000	-	-		FOG0000231
OrthoInspector	1	1.000	-	-		otm51342
orthoMCL	1	0.900	-	-		OOG6_100158
Panther	1	1.100	-	-	P	PTHR42861
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	9	8.750