Protein Alignment SPoCk and ATP2B1

DIOPT Version :10

• Sequence 1: NP_001262220.1
• Gene: SPoCk / 40495
• FlyBaseID: FBgn0052451
• Length: 1062
• Species: Drosophila melanogaster
• Sequence 2: NP_001353453.1
• Gene: ATP2B1 / 490
• HGNCID: 814
• Length: 1249
• Species: Homo sapiens
• Alignment Length: 1093
• Identity: 280/1093 - (25%)
• Similarity: 468/1093 - (42%)
• Gaps: 276/1093 - (25%)

  Fly    97 GLTLTPEMLLSTSESS------THSASEVAG---RLQVDVRTGLKWTEA--KYRAKIIGHNELLL 150
            |:||.....|....|:      ..|..:|.|   :|:.....||....|  :.|..:.|.|  .:
Human    28 GITLAELRALMELRSTDALRKIQESYGDVYGICTKLKTSPNEGLSGNPADLERREAVFGKN--FI 90

  Fly   151 VAEDP-TWKKYI-EQFRNPLILLLLGSALVSVIMKQF-----DDAV------------------- 189
            ..:.| |:.:.: |..::..:::|..:|:||:.:..:     |:|:
Human    91 PPKKPKTFLQLVWEALQDVTLIILEIAAIVSLGLSFYQPPEGDNALCGEVSVGEEEGEGETGWIE 155

  Fly   190 --SITIAILIVVTVAFIQEYRSEKSLEELKKLVPPE--CHCLREGRLDTFLARELVPGDIVHLNV 250
              :|.::::.||.|....::..||....|:..:..|  ...:|.|::......::..|||..:..
Human   156 GAAILLSVVCVVLVTAFNDWSKEKQFRGLQSRIEQEQKFTVIRGGQVIQIPVADITVGDIAQVKY 220

  Fly   251 GDRVPADVRLFEAVDLSIDESSFTGETEPARKITD---VLLNNTNVKDHSNMKNIAFMGTLVRCG 312
            ||.:|||..|.:..||.|||||.|||::..:|..|   :||:.|:|.:                |
Human   221 GDLLPADGILIQGNDLKIDESSLTGESDHVKKSLDKDPLLLSGTHVME----------------G 269

  Fly   313 NGKGIVVSTGERSEFGEVFKM-------------------------------------------- 333
            :|:.:|.:.|..|:.|.:|.:
Human   270 SGRMVVTAVGVNSQTGIIFTLLGAGGEEEEKKDEKKKEKKNKKQDGAIENRNKAKAQDGAAMEMQ 334

  Fly   334 -MQAEEA----------------PKTPLQKSMDILGAQLSFYSFLI--IGVIMLL-------GWL 372
             :::||.                .|:.||..:..|..|:.....|:  |.||:|:       .|:
Human   335 PLKSEEGGDGDEKDKKKANLPKKEKSVLQGKLTKLAVQIGKAGLLMSAITVIILVLYFVIDTFWV 399

  Fly   373 QGKP-LSE-----------MFNISVSLAVAAIPEGLPIVVTVTLALGVMRMAKRNSIVKKLPTVE 425
            |.:| |:|           .|.|.|::.|.|:|||||:.||::||..|.:|.|.|::|:.|...|
Human   400 QKRPWLAECTPIYIQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACE 464

  Fly   426 TLGCVNVICSDKTGTLTKNEMTATIIITSDGYMADVTGAGYNDQGEIHIRHCNNVEMAKTNITNL 490
            |:|....||||||||||.|.||             |..|..|::   |.:.....|....||.:.
Human   465 TMGNATAICSDKTGTLTMNRMT-------------VVQAYINEK---HYKKVPEPEAIPPNILSY 513

  Fly   491 LEIGAVCNNAYI-------QNGTL---LGQPTEGALVAVAMK-NGMYATAENYV----RIQEYPF 540
            |..|...|.||.       :.|.|   :|..||.||:.:.:. ...|....|.:    ..:.|.|
Human   514 LVTGISVNCAYTSKILPPEKEGGLPRHVGNKTECALLGLLLDLKRDYQDVRNEIPEEALYKVYTF 578

  Fly   541 SSEQKMMAVKCIHKYNNNKEEIFFAKGALETLLPQCTKYQFGTQTVPLTKQNEAEFLAEAY--EI 603
            :|.:|.|:.  :.|.::....| |:|||.|.:|.:|.|.........:.:..:.:.:.:..  .:
Human   579 NSVRKSMST--VLKNSDGSYRI-FSKGASEIILKKCFKILSANGEAKVFRPRDRDDIVKTVIEPM 640

  Fly   604 GRKGLRVLALA---------------KGRSMQDLIYCGLVGITDPPRPLVRESIEMLMQSGVRVK 653
            ..:|||.:.||               :...:..|....:|||.||.||.|.::|:...::|:.|:
Human   641 ASEGLRTICLAFRDFPAGEPEPEWDNENDIVTGLTCIAVVGIEDPVRPEVPDAIKKCQRAGITVR 705

  Fly   654 MVTGDAQETALAIDPSRRLQAVPTHAIPAWPTAGGVPLCSASACCSTN------CLENAMKEIYL 712
            |||||...||.||                           |:.|...:      |||.  |:...
Human   706 MVTGDNINTARAI---------------------------ATKCGILHPGEDFLCLEG--KDFNR 741

  Fly   713 TALAQQGLPLVTANLIGIDTIHHQTLSGQEMDQMNEHQLDKVANNVSVFYRVSPRHKLEIVKSL- 776
            ....::|                         ::.:.::||:...:.|..|.||..|..:||.:
Human   742 RIRNEKG-------------------------EIEQERIDKIWPKLRVLARSSPTDKHTLVKGII 781

  Fly   777 ------QRSGNIVGMTGDGVNDGVALKKADIGIAMGKNGTDVCKEAADMILVNDDFHTIIAAIEE 835
                  ||  .:|.:||||.|||.||||||:|.|||..||||.|||:|:||.:|:|.:|:.|:..
Human   782 DSTVSDQR--QVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMW 844

  Fly   836 GKGIFYNIRNFVRFQLSTSIAALALIALATLMDIANPLNAMQILWINIIMDGPPAQSLGVEPVDH 900
            |:.::.:|..|::|||:.::.|:.:......:...:||.|:|:||:|:|||...:.:|..||...
Human   845 GRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTLASLALATEPPTE 909

  Fly   901 DVLKQKPRNVKQPMITKSVVVNVLLSA--SIIVLGTLWVFQREMADGTLGKT-------KRDTTM 956
            .:|.:||....:|:|:::::.|:|..|  .::|:.||.....:..|...|:.       ....|:
Human   910 SLLLRKPYGRNKPLISRTMMKNILGHAFYQLVVVFTLLFAGEKFFDIDSGRNAPLHAPPSEHYTI 974

  Fly   957 TFTCFVFFDMFNALSCRS--QTKSVFTIGLTTNRMFLLAVAFSIIGQMLVVYF 1007
            .|..||...:||.::.|.  ..::||. |:..|.:|...|..:.:.|:::|.|
Human   975 VFNTFVLMQLFNEINARKIHGERNVFE-GIFNNAIFCTIVLGTFVVQIIIVQF 1026

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SPoCk	NP_001262220.1	P-type_ATPase_SPCA	139..1042	CDD:319779	268/1040 (26%)
ATP2B1	NP_001353453.1	ATPase-IIB_Ca	15..1064	CDD:273668	280/1093 (26%)
		ATP_Ca_trans_C	1103..1178	CDD:463575