DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SPoCk and ATP2A1

DIOPT Version :9

Sequence 1:NP_001262220.1 Gene:SPoCk / 40495 FlyBaseID:FBgn0052451 Length:1062 Species:Drosophila melanogaster
Sequence 2:NP_775293.1 Gene:ATP2A1 / 487 HGNCID:811 Length:1001 Species:Homo sapiens


Alignment Length:1041 Identity:331/1041 - (31%)
Similarity:509/1041 - (48%) Gaps:188/1041 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   125 VDVRTGLKWTEAKYRAKIIGHNELLLVAEDPTWKKYIEQFRNPLILLLLGSALVSVIMKQFDDA- 188
            |...|||...:.|...:..|.|||........|:..||||.:.|:.:||.:|.:|.::..|::. 
Human    18 VSETTGLTPDQVKRNLEKYGLNELPAEEGKTLWELVIEQFEDLLVRILLLAACISFVLAWFEEGE 82

  Fly   189 ------VSITIAILIVVTVAFI---QEYRSEKSLEELKKLVPPECHCLREGR--LDTFLARELVP 242
                  |...:.:||::..|.:   ||..:|.::|.||:..|......|..|  :....||::||
Human    83 ETITAFVEPFVILLILIANAIVGVWQERNAENAIEALKEYEPEMGKVYRADRKSVQRIKARDIVP 147

  Fly   243 GDIVHLNVGDRVPADVRL--FEAVDLSIDESSFTGETEPARKITDVLLNNTNVKDHSNMKNIAFM 305
            ||||.:.|||:||||:|:  .::..|.:|:|..|||:....|.|:.:.:...|  :.:.||:.|.
Human   148 GDIVEVAVGDKVPADIRILAIKSTTLRVDQSILTGESVSVIKHTEPVPDPRAV--NQDKKNMLFS 210

  Fly   306 GTLVRCGNGKGIVVSTGERSEFGEVFKMMQAEEAPKTPLQKSMDILGAQLSFYSFLIIGVIMLL- 369
            ||.:..|...|||.:||..:|.|::...|.|.|..|||||:.:|..|.|||....||...:.|: 
Human   211 GTNIAAGKALGIVATTGVGTEIGKIRDQMAATEQDKTPLQQKLDEFGEQLSKVISLICVAVWLIN 275

  Fly   370 -----------GWLQGKPLSEMFNISVSLAVAAIPEGLPIVVTVTLALGVMRMAKRNSIVKKLPT 423
                       .|.:|  ....|.|:|:|||||||||||.|:|..||||..||||:|:||:.||:
Human   276 IGHFNDPVHGGSWFRG--AIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPS 338

  Fly   424 VETLGCVNVICSDKTGTLTKNEMTAT---IIITSDGYMA-----DVTGAGYNDQGEIHIRHCNNV 480
            ||||||.:|||||||||||.|:|:..   ||...||.:.     .:||:.|..:||: :::...|
Human   339 VETLGCTSVICSDKTGTLTTNQMSVCKMFIIDKVDGDICLLNEFSITGSTYAPEGEV-LKNDKPV 402

  Fly   481 EMAK-TNITNLLEIGAVCNNAYIQ----NGTL--LGQPTEGALVAVAMKNGMY------------ 526
            ...: ..:..|..|.|:||::.:.    .|..  :|:.||.||..:..|..::            
Human   403 RPGQYDGLVELATICALCNDSSLDFNEAKGVYEKVGEATETALTTLVEKMNVFNTDVRSLSKVER 467

  Fly   527 ATAENYVRIQ----EY--PFSSEQKMMAVKCIHKYNN-----NKEEIFFAKGALETLLPQCTKYQ 580
            |.|.|.|..|    |:  .||.::|.|:|.|....::     ||   .|.|||.|.::.:|...:
Human   468 ANACNSVIRQLMKKEFTLEFSRDRKSMSVYCSPAKSSRAAVGNK---MFVKGAPEGVIDRCNYVR 529

  Fly   581 FGTQTVPLTKQNEAEFLA--EAYEIGRKGLRVLALA------KGRSM------------QDLIYC 625
            .||..||||...:.:.:|  :.:..||..||.||||      |...|            .||.:.
Human   530 VGTTRVPLTGPVKEKIMAVIKEWGTGRDTLRCLALATRDTPPKREEMVLDDSARFLEYETDLTFV 594

  Fly   626 GLVGITDPPRPLVRESIEMLMQSGVRVKMVTGDAQETALAIDPSRRLQAVPTHAIPAWPTAGGVP 690
            |:||:.||||..|..||::...:|:||.|:|||.:.||:||  .||                   
Human   595 GVVGMLDPPRKEVTGSIQLCRDAGIRVIMITGDNKGTAIAI--CRR------------------- 638

  Fly   691 LCSASACCSTNCLENAMKEIYLTALAQQGLPLVTANLIGI----DTIHHQTLSGQEMDQMNEHQL 751
                                                 |||    :.:..:..:|:|.|.:...:.
Human   639 -------------------------------------IGIFGENEEVADRAYTGREFDDLPLAEQ 666

  Fly   752 DKVANNVSVFYRVSPRHKLEIVKSLQRSGNIVGMTGDGVNDGVALKKADIGIAMGKNGTDVCKEA 816
            .:.......|.||.|.||.:||:.||....|..||||||||..|||||:|||||| :||.|.|.|
Human   667 REACRRACCFARVEPSHKSKIVEYLQSYDEITAMTGDGVNDAPALKKAEIGIAMG-SGTAVAKTA 730

  Fly   817 ADMILVNDDFHTIIAAIEEGKGIFYNIRNFVRFQLSTSIAALALIALATLMDIANPLNAMQILWI 881
            ::|:|.:|:|.||:||:|||:.|:.|::.|:|:.:|:::..:..|.|...:.:...|..:|:||:
Human   731 SEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGLPEALIPVQLLWV 795

  Fly   882 NIIMDGPPAQSLGVEPVDHDVLKQKPRNVKQPMIT-----KSVVVNVLLSASIIVLGTLWVFQRE 941
            |::.||.||.:||..|.|.|::.:.||:.|:|:|:     :.:.:...:.|:.:.....|....|
Human   796 NLVTDGLPATALGFNPPDLDIMDRPPRSPKEPLISGWLFFRYMAIGGYVGAATVGAAAWWFLYAE 860

  Fly   942 MADGT----------LGKTKRDT----------------TMTFTCFVFFDMFNALSCRSQTKSVF 980
              ||.          :..|:.:|                ||..:..|..:|.|||:..|:.:|:.
Human   861 --DGPHVNYSQLTHFMQCTEDNTHFEGIDCEVFEAPEPMTMALSVLVTIEMCNALNSLSENQSLL 923

  Fly   981 TIGLTTNRMFLLAVAFSIIGQMLVVYFPPLQMVFQTEALTPYDIFFLVSLTSSVLVVSEIKKWFE 1045
            .:....|...|.::..|:....|::|..||.|:|:..||.......::.::..|:.:.||.|:..
Human   924 RMPPWVNIWLLGSICLSMSLHFLILYVDPLPMIFKLRALDLTQWLMVLKISLPVIGLDEILKFVA 988

  Fly  1046 R 1046
            |
Human   989 R 989

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SPoCkNP_001262220.1 ATPase-IIA2_Ca 110..1049 CDD:130585 331/1041 (32%)
Cation_ATPase_N 112..179 CDD:279080 18/53 (34%)
E1-E2_ATPase 191..425 CDD:278548 97/252 (38%)
Cation_ATPase 496..579 CDD:289987 29/111 (26%)
COG4087 <760..823 CDD:226572 37/62 (60%)
Cation_ATPase_C 872..1044 CDD:279079 50/202 (25%)
ATP2A1NP_775293.1 Cation_ATPase_N 4..72 CDD:279080 18/53 (34%)
ATPase-IIA1_Ca 53..989 CDD:273452 320/1004 (32%)
E1-E2_ATPase 93..340 CDD:278548 97/250 (39%)
Cation_ATPase 419..528 CDD:289987 29/111 (26%)
HAD <611..712 CDD:289480 40/158 (25%)
Cation_ATPase_C 784..987 CDD:279079 50/204 (25%)
Interaction with PLN. /evidence=ECO:0000250|UniProtKB:P04191 788..808 8/19 (42%)
Interaction with PLN. /evidence=ECO:0000250|UniProtKB:P04191 932..943 2/10 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165141102
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0202
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53587
OrthoDB 1 1.010 - - D100699at2759
OrthoFinder 1 1.000 - - FOG0000231
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100158
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
76.660

Return to query results.
Submit another query.