DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SPoCk and ATP1A4

DIOPT Version :9

Sequence 1:	NP_001262220.1	Gene:	SPoCk / 40495	FlyBaseID:	FBgn0052451	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	NP_653300.2	Gene:	ATP1A4 / 480	HGNCID:	14073	Length:	1029	Species:	Homo sapiens

Alignment Length:	1123	Identity:	310/1123 - (27%)
Similarity:	493/1123 - (43%)	Gaps:	242/1123 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 HVKDSRAVPQNVKPGKVADMKDCKEPDEDNVDQQNGNIIQTGLTLTPEMLLSTSESSTHSASEVA 120
            |.:..|..|   |.|.:......:|..:.|:::....::.....||.|              |::
Human    13 HDQSPRRRP---KKGLIKKKMVKREKQKRNMEELKKEVVMDDHKLTLE--------------ELS 60

  Fly   121 GRLQVDVRTGLKWTEAKYRAKII----GHNELLLVAEDPTWKKYIEQ-FRNPLILLLLGSALVSV 180
            .:..||:..|    .:..|||.|    |.|.:......|.|.|:.:| |....:||..|:.|..|
Human    61 TKYSVDLTKG----HSHQRAKEILTRGGPNTVTPPPTTPEWVKFCKQLFGGFSLLLWTGAILCFV 121

  Fly   181 ---IMKQFDDA-------VSITIAILIVVT--VAFIQEYRSEKSLEELKKLVPPECHCLREGRLD 233
               |...|::.       :||.::::::||  .::.||.:|.|.:|..|.:||.:...:|.|...
Human   122 AYSIQIYFNEEPTKDNLYLSIVLSVVVIVTGCFSYYQEAKSSKIMESFKNMVPQQALVIRGGEKM 186

  Fly   234 TFLARELVPGDIVHLNVGDRVPADVRLFEAVDLSIDESSFTGETEPARKITDVLLNNTNVKDHSN 298
            ....:|:|.||:|.:..|||||||:||..|....:|.||.|||:||..:..|.        .|.|
Human   187 QINVQEVVLGDLVEIKGGDRVPADLRLISAQGCKVDNSSLTGESEPQSRSPDF--------THEN 243

  Fly   299 ---MKNIAFMGTLVRCGNGKGIVVSTGERSEFGEVFKMMQAEEAPKTPLQKSMD----------- 349
               .:||.|..|....|..:|||::||:.:..|.:..:.......:||:...::
Human   244 PLETRNICFFSTNCVEGTARGIVIATGDSTVMGRIASLTSGLAVGQTPIAAEIEHFIHLITVVAV 308

  Fly   350 ILGAQLSFYSFLIIGVIMLLGWLQGKPLSEMFNISVSLAVAAIPEGLPIVVTVTLALGVMRMAKR 414
            .||.     :|..:.:::..|||      |.....:.:.||.:||||...|||.|.|...|||::
Human   309 FLGV-----TFFALSLLLGYGWL------EAIIFLIGIIVANVPEGLLATVTVCLTLTAKRMARK 362

  Fly   415 NSIVKKLPTVETLGCVNVICSDKTGTLTKNEMT-ATIIITSDGYMADVTGAGYNDQGEIHIRHCN 478
            |.:||.|..|||||..:.||||||||||:|.|| |.:......|.||.|   ....|:...:..:
Human   363 NCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDMTVYEADTT---EEQTGKTFTKSSD 424

  Fly   479 NVEMAKTNITNLLEIGAVCNNA-YIQNGTLL--------GQPTEGALVAVAMKNGMYATA----E 530
            ...|       |..|..:||.| :..|..:|        |..:|.||:....::  |::.    |
Human   425 TWFM-------LARIAGLCNRADFKANQEILPIAKRATTGDASESALLKFIEQS--YSSVAEMRE 480

  Fly   531 NYVRIQEYPFSSEQKMMAVKCIH-KYNNNKEEIFFAKGALETLLPQCTKYQFGTQTVPLTKQNEA 594
            ...::.|.||:|..|..  ..|| :.::::..:...|||.|.:|..|:.:....|...:..:.:.
Human   481 KNPKVAEIPFNSTNKYQ--MSIHLREDSSQTHVLMMKGAPERILEFCSTFLLNGQEYSMNDEMKE 543

  Fly   595 EFLAEAYEIGRKGLRVL---------ALAKG---------RSMQDLIYCGLVGITDPPRPLVRES 641
            .|.....|:|..|.|||         :.:||         ..|.:|.:.||:.:.||||..|.::
Human   544 AFQNAYLELGGLGERVLGFCFLNLPSSFSKGFPFNTDEINFPMDNLCFVGLISMIDPPRAAVPDA 608

  Fly   642 IEMLMQSGVRVKMVTGDAQETALAIDPSRRLQAVPTHAIPAWPTAGGVPLCSASACCSTNCLENA 706
            :.....:|::|.|||||                   |.|.|...|.||.:.|...       |.|
Human   609 VSKCRSAGIKVIMVTGD-------------------HPITAKAIAKGVGIISEGT-------ETA 647

  Fly   707 MKEIYLTALAQQGLPL--VTANLIGIDTIHHQTLSGQEMDQMNEHQLDKVANN--VSVFYRVSPR 767
             :|:    .|:..:|:  |.|:......:|     |.|:..:...|||::..|  ..||.|.||:
Human   648 -EEV----AARLKIPISKVDASAAKAIVVH-----GAELKDIQSKQLDQILQNHPEIVFARTSPQ 702

  Fly   768 HKLEIVKSLQRSGNIVGMTGDGVNDGVALKKADIGIAMGKNGTDVCKEAADMILVNDDFHTIIAA 832
            .||.||:..||.|.:|.:|||||||..||||||||||||.:|:||.|:||||||::|:|.:|:..
Human   703 QKLIIVEGCQRLGAVVAVTGDGVNDSPALKKADIGIAMGISGSDVSKQAADMILLDDNFASIVTG 767

  Fly   833 IEEGKGIFYNIRNFVRFQLSTSIAALALIALATLMDIANPLNAMQILWINIIMDGPPAQSLGVEP 897
            :|||:.||.|::..:.:.|:::|..:....:..::.|..||..:.||.|::..|..||.||..|.
Human   768 VEEGRLIFDNLKKSIMYTLTSNIPEITPFLMFIILGIPLPLGTITILCIDLGTDMVPAISLAYES 832

  Fly   898 VDHDVLKQKPRNVKQPMITKSVVVNVLLSAS----------------IIVL-------------- 932
            .:.|::|:.|||.|    |.::|.:.|:..:                .::|
Human   833 AESDIMKRLPRNPK----TDNLVNHRLIGMAYGQIGMIQALAGFFTYFVILAENGFRPVDLLGIR 893

  Fly   933 ---------------GTLWVF-QREMADGTLGKTKRDTTMTFTCFVFFDMFNALSCRSQTKSVFT 981
                           |..|.: ||::.:.|.      .|..|...|.....:.:..:::..|:|.
Human   894 LHWEDKYLNDLEDSYGQQWTYEQRKVVEFTC------QTAFFVTIVVVQWADLIISKTRRNSLFQ 952

  Fly   982 IGLTTNRMFLLAVAFSIIGQMLVVYFP---------PLQMVFQTEALTPYDIFFLVSLTSSVLVV 1037
            .|: .|::.:..:....:....:.|.|         ||::.:...|: ||.|.        :.|.
Human   953 QGM-RNKVLIFGILEETLLAAFLSYTPGMDVALRMYPLKITWWLCAI-PYSIL--------IFVY 1007

  Fly  1038 SEIKK---------WFER 1046
            .||:|         |.||
Human  1008 DEIRKLLIRQHPDGWVER 1025

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPoCk	NP_001262220.1	ATPase-IIA2_Ca	110..1049	CDD:130585	300/1069 (28%)
		Cation_ATPase_N	112..179	CDD:279080	19/71 (27%)
		E1-E2_ATPase	191..425	CDD:278548	77/249 (31%)
		Cation_ATPase	496..579	CDD:289987	24/96 (25%)
		COG4087	<760..823	CDD:226572	42/62 (68%)
		Cation_ATPase_C	872..1044	CDD:279079	45/235 (19%)
ATP1A4	NP_653300.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..37		6/26 (23%)
		ATPase-IIC_X-K	35..1029	CDD:273445	304/1098 (28%)
		Cation_ATPase_N	49..122	CDD:214842	22/90 (24%)
		Interaction with phosphoinositide-3 kinase. /evidence=ECO:0000250	90..92		0/1 (0%)
		E1-E2_ATPase	154..373	CDD:278548	74/237 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	223..242		8/26 (31%)
		Cation_ATPase	435..527	CDD:289987	24/95 (25%)
		COG4087	609..758	CDD:226572	70/184 (38%)
		Cation_ATPase_C	805..1014	CDD:279079	45/228 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141086
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.850