Protein Alignment SPoCk and ATP1A2

DIOPT Version :10

• Sequence 1: NP_001262220.1
• Gene: SPoCk / 40495
• FlyBaseID: FBgn0052451
• Length: 1062
• Species: Drosophila melanogaster
• Sequence 2: NP_000693.1
• Gene: ATP1A2 / 477
• HGNCID: 800
• Length: 1020
• Species: Homo sapiens
• Alignment Length: 1058
• Identity: 306/1058 - (28%)
• Similarity: 479/1058 - (45%)
• Gaps: 212/1058 - (20%)

  Fly   115 SASEVAGRLQVDVRTGLKWTEAKYRAKII----GHNELLLVAEDPTWKKYIEQ-FRNPLILLLLG 174
            |..|:..:.|||:..||    ...||:.:    |.|.|......|.|.|:..| |....|||.:|
Human    45 SLDELGRKYQVDLSKGL----TNQRAQDVLARDGPNALTPPPTTPEWVKFCRQLFGGFSILLWIG 105

  Fly   175 SALVSV---IMKQFDDAVS-------ITIAILIVVT--VAFIQEYRSEKSLEELKKLVPPECHCL 227
            :.|..:   |....:|..|       :.:|.:::||  .::.||.:|.|.::..|.:||.:...:
Human   106 AILCFLAYGIQAAMEDEPSNDNLYLGVVLAAVVIVTGCFSYYQEAKSSKIMDSFKNMVPQQALVI 170

  Fly   228 REGRLDTFLARELVPGDIVHLNVGDRVPADVRLFEAVDLSIDESSFTGETEPARKITDVLLNNTN 292
            |||......|.|:|.||:|.:..|||||||:|:..:....:|.||.|||:||..:..:.
Human   171 REGEKMQINAEEVVVGDLVEVKGGDRVPADLRIISSHGCKVDNSSLTGESEPQTRSPEF------ 229

  Fly   293 VKDHSN---MKNIAFMGTLVRCGNGKGIVVSTGERSEFGEVFKMMQAEEAPKTPLQKSMD----- 349
              .|.|   .:||.|..|....|..:|||::||:|:..|.:..:....|..:||:...::
Human   230 --THENPLETRNICFFSTNCVEGTARGIVIATGDRTVMGRIATLASGLEVGRTPIAMEIEHFIQL 292

  Fly   350 ILGAQLSF-YSFLIIGVIMLLGWLQGKPLSEMFNISVSLAVAAIPEGLPIVVTVTLALGVMRMAK 413
            |.|..:.. .||.::.:|:...||      |.....:.:.||.:||||...|||.|.|...|||:
Human   293 ITGVAVFLGVSFFVLSLILGYSWL------EAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMAR 351

  Fly   414 RNSIVKKLPTVETLGCVNVICSDKTGTLTKNEMT-ATIIITSDGYMADVT----GAGYNDQGEIH 473
            :|.:||.|..|||||..:.||||||||||:|.|| |.:...:..:.||.|    ||.::.:
Human   352 KNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTEDQSGATFDKR---- 412

  Fly   474 IRHCNNVEMAKTNITNLLEIGAVCNNAYIQNG---------TLLGQPTEGALV-AVAMKNG-MYA 527
                      ....|.|..|..:||.|..:.|         ...|..:|.||: .:.:..| :..
Human   413 ----------SPTWTALSRIAGLCNRAVFKAGQENISVSKRDTAGDASESALLKCIELSCGSVRK 467

  Fly   528 TAENYVRIQEYPFSSEQKMMAVKCIHKYNNN-KEEIFFAKGALETLLPQCTKYQFGTQTVPLTKQ 591
            ..:...::.|.||:|..|...  .||:..:: :..:...|||.|.:|.:|:......:.:||.|:
Human   468 MRDRNPKVAEIPFNSTNKYQL--SIHEREDSPQSHVLVMKGAPERILDRCSTILVQGKEIPLDKE 530

  Fly   592 NEAEFLAEAYEIGRKGLRVLA-----LAKGR--------------SMQDLIYCGLVGITDPPRPL 637
            .:..|.....|:|..|.|||.     |..|:              ..:.|.:.||:.:.||||..
Human   531 MQDAFQNAYMELGGLGERVLGFCQLNLPSGKFPRGFKFDTDELNFPTEKLCFVGLMSMIDPPRAA 595

  Fly   638 VRESIEMLMQSGVRVKMVTGDAQETALAIDPSRRLQAVPTHAIPAWPTAGGVPLCSASACCSTNC 702
            |.:::.....:|::|.|||||                   |.|.|...|.||.:.|..
Human   596 VPDAVGKCRSAGIKVIMVTGD-------------------HPITAKAIAKGVGIISEG------- 634

  Fly   703 LENAMKEIYLTALAQQGLPL--VTANLIGIDTIHHQTLSGQEMDQMNEHQLDKVANNVS--VFYR 763
             ...:::|    .|:..:|:  |.........:|     |.::..|...|||::..|.:  ||.|
Human   635 -NETVEDI----AARLNIPMSQVNPREAKACVVH-----GSDLKDMTSEQLDEILKNHTEIVFAR 689

  Fly   764 VSPRHKLEIVKSLQRSGNIVGMTGDGVNDGVALKKADIGIAMGKNGTDVCKEAADMILVNDDFHT 828
            .||:.||.||:..||.|.||.:|||||||..||||||||||||.:|:||.|:||||||::|:|.:
Human   690 TSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGIAMGISGSDVSKQAADMILLDDNFAS 754

  Fly   829 IIAAIEEGKGIFYNIRNFVRFQLSTSIAALALIALATLMDIANPLNAMQILWINIIMDGPPAQSL 893
            |:..:|||:.||.|::..:.:.|:::|..:....|..:.:|..||..:.||.|::..|..||.||
Human   755 IVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLLFIIANIPLPLGTVTILCIDLGTDMVPAISL 819

  Fly   894 GVEPVDHDVLKQKPRNVKQPMITKSVVVNVLLSAS------IIVLGTLWVFQREMADG------T 946
            ..|..:.|::|::|||.:    |..:|...|:|.:      |..||..:.:...:|:.      .
Human   820 AYEAAESDIMKRQPRNSQ----TDKLVNERLISMAYGQIGMIQALGGFFTYFVILAENGFLPSRL 880

  Fly   947 LG-------KTKRD--------------TTMTFTCFVFF-------DMFNALSCRSQTKSVFTIG 983
            ||       :|..|              ..:.|||...|       ...:.:.|:::..|||..|
Human   881 LGIRLDWDDRTMNDLEDSYGQEWTYEQRKVVEFTCHTAFFASIVVVQWADLIICKTRRNSVFQQG 945

  Fly   984 LTTNRMFL--------LAVAFSI---IGQMLVVYFPPLQMVFQTEALTPYDIFFLVSLTSSVLVV 1037
            : .|::.:        ||...|.   :|..|.:|  ||::.:...|. ||.:.        :.:.
Human   946 M-KNKILIFGLLEETALAAFLSYCPGMGVALRMY--PLKVTWWFCAF-PYSLL--------IFIY 998

  Fly  1038 SEIKK---------WFER 1046
            .|::|         |.|:
Human   999 DEVRKLILRRYPGGWVEK 1016

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SPoCk	NP_001262220.1	P-type_ATPase_SPCA	139..1042	CDD:319779	296/1019 (29%)
ATP1A2	NP_000693.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..31
		ATPase-IIC_X-K	30..1020	CDD:273445	306/1058 (29%)
		Interaction with phosphoinositide-3 kinase. /evidence=ECO:0000250	80..82		0/1 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	212..231		8/26 (31%)