DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SPoCk and ATP1A1

DIOPT Version :9

Sequence 1:	NP_001262220.1	Gene:	SPoCk / 40495	FlyBaseID:	FBgn0052451	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	NP_000692.2	Gene:	ATP1A1 / 476	HGNCID:	799	Length:	1023	Species:	Homo sapiens

Alignment Length:	1118	Identity:	310/1118 - (27%)
Similarity:	486/1118 - (43%)	Gaps:	214/1118 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 KGVDSKPNPQRTISHVKDSRAVPQNVKPGKVADMKDCKEPDEDNVDQQNGNIIQTGLTLTPEMLL 106
            |||.........:|...|.:.     |.||       |:.|.|.:.::        :::....|
Human     3 KGVGRDKYEPAAVSEQGDKKG-----KKGK-------KDRDMDELKKE--------VSMDDHKL- 46

  Fly   107 STSESSTHSASEVAGRLQVDVRTGLKWTEAKYRAKII---GHNELLLVAEDPTWKKYIEQFRNPL 168
                    |..|:..:...|:..||  |.|: .|:|:   |.|.|......|.|.|:..|.....
Human    47 --------SLDELHRKYGTDLSRGL--TSAR-AAEILARDGPNALTPPPTTPEWIKFCRQLFGGF 100

  Fly   169 ILLLLGSALVSVIMKQFDDA-----------VSITIAILIVVT--VAFIQEYRSEKSLEELKKLV 220
            .:||...|::..:......|           :.:.::.::::|  .::.||.:|.|.:|..|.:|
Human   101 SMLLWIGAILCFLAYSIQAATEEEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMV 165

  Fly   221 PPECHCLREGRLDTFLARELVPGDIVHLNVGDRVPADVRLFEAVDLSIDESSFTGETEPARKITD 285
            |.:...:|.|...:..|.|:|.||:|.:..|||:|||:|:..|....:|.||.|||:||..:..|
Human   166 PQQALVIRNGEKMSINAEEVVVGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEPQTRSPD 230

  Fly   286 VLLNNTNVKDHSNMKNIAFMGTLVRCGNGKGIVVSTGERSEFGEVFKMMQAEEAPKTPLQKSMDI 350
              ..|.|..:   .:||||..|....|..:||||.||:|:..|.:..:....|..:||
Human   231 --FTNENPLE---TRNIAFFSTNCVEGTARGIVVYTGDRTVMGRIATLASGLEGGQTP------- 283

  Fly   351 LGAQLSFYSFLIIGVIMLLG-------------WLQGKPLSEMFNISVSLAVAAIPEGLPIVVTV 402
            :.|::..:..:|.||.:.||             ||      |.....:.:.||.:||||...|||
Human   284 IAAEIEHFIHIITGVAVFLGVSFFILSLILEYTWL------EAVIFLIGIIVANVPEGLLATVTV 342

  Fly   403 TLALGVMRMAKRNSIVKKLPTVETLGCVNVICSDKTGTLTKNEMT-ATIIITSDGYMADVTGAGY 466
            .|.|...|||::|.:||.|..|||||..:.||||||||||:|.|| |.:...:..:.||.|   .
Human   343 CLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTT---E 404

  Fly   467 NDQGEIHIRHCNNVEMAKTNIT--NLLEIGAVCNNAYIQ---------NGTLLGQPTEGALV-AV 519
            |..|         |...||:.|  .|..|..:||.|..|         ...:.|..:|.||: .:
Human   405 NQSG---------VSFDKTSATWLALSRIAGLCNRAVFQANQENLPILKRAVAGDASESALLKCI 460

  Fly   520 AMKNG-MYATAENYVRIQEYPFSSEQKMMAVKCIHKYNNNKE--EIFFAKGALETLLPQCTKYQF 581
            .:..| :....|.|.:|.|.||:|..|...  .|||..|..|  .:...|||.|.:|.:|:....
Human   461 ELCCGSVKEMRERYAKIVEIPFNSTNKYQL--SIHKNPNTSEPQHLLVMKGAPERILDRCSSILL 523

  Fly   582 GTQTVPLTKQNEAEFLAEAYEIGRKGLRVLALAK-------------------GRSMQDLIYCGL 627
            ..:..||.::.:..|.....|:|..|.|||....                   ...:.:|.:.||
Human   524 HGKEQPLDEELKDAFQNAYLELGGLGERVLGFCHLFLPDEQFPEGFQFDTDDVNFPIDNLCFVGL 588

  Fly   628 VGITDPPRPLVRESIEMLMQSGVRVKMVTGDAQETALAIDPSRRLQAVPTHAIPAWPTAGGVPLC 692
            :.:.||||..|.:::.....:|::|.|||||                   |.|.|...|.||.:.
Human   589 ISMIDPPRAAVPDAVGKCRSAGIKVIMVTGD-------------------HPITAKAIAKGVGII 634

  Fly   693 SASACCSTNCLENAMKEIYLTALAQQGLPLVTANLIGID--TIHHQTLSGQEMDQMNEHQLDKVA 755
            |..        ...:::|    .|:..:|:...|.....  .:|     |.::..|...|||.:.
Human   635 SEG--------NETVEDI----AARLNIPVSQVNPRDAKACVVH-----GSDLKDMTSEQLDDIL 682

  Fly   756 --NNVSVFYRVSPRHKLEIVKSLQRSGNIVGMTGDGVNDGVALKKADIGIAMGKNGTDVCKEAAD 818
              :...||.|.||:.||.||:..||.|.||.:|||||||..||||||||:|||..|:||.|:|||
Human   683 KYHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAAD 747

  Fly   819 MILVNDDFHTIIAAIEEGKGIFYNIRNFVRFQLSTSIAALALIALATLMDIANPLNAMQILWINI 883
            |||::|:|.:|:..:|||:.||.|::..:.:.|:::|..:....:..:.:|..||..:.||.|::
Human   748 MILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLIFIIANIPLPLGTVTILCIDL 812

  Fly   884 IMDGPPAQSLGVEPVDHDVLKQKPRNVKQPMITKSVVVN-------------------VLLSAS- 928
            ..|..||.||..|..:.|::|::|||.|...:....:::                   |:|:.:
Human   813 GTDMVPAISLAYEQAESDIMKRQPRNPKTDKLVNERLISMAYGQIGMIQALGGFFTYFVILAENG 877

  Fly   929 ---IIVLG------TLWVFQREMADGTLGKTKRDTTMTFTCFVFF-------DMFNALSCRSQTK 977
               |.:||      ..|:...|.:.|.....::...:.|||...|       ...:.:.|:::..
Human   878 FLPIHLLGLRVDWDDRWINDVEDSYGQQWTYEQRKIVEFTCHTAFFVSIVVVQWADLVICKTRRN 942

  Fly   978 SVFTIGLTTNRMFLLAVAFSIIGQMLVVYFPPLQMVFQTEALTPYDIFFLVSLTSSVLVVSEIKK 1042
            |||..|: .|::.:..:.........:.|.|.:.:..:...|.|...|.....:..:.|..|::|
Human   943 SVFQQGM-KNKILIFGLFEETALAAFLSYCPGMGVALRMYPLKPTWWFCAFPYSLLIFVYDEVRK 1006

  Fly  1043 ---------WFER 1046
                     |.|:
Human  1007 LIIRRRPGGWVEK 1019

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPoCk	NP_001262220.1	ATPase-IIA2_Ca	110..1049	CDD:130585	298/1050 (28%)
		Cation_ATPase_N	112..179	CDD:279080	19/69 (28%)
		E1-E2_ATPase	191..425	CDD:278548	80/248 (32%)
		Cation_ATPase	496..579	CDD:289987	28/95 (29%)
		COG4087	<760..823	CDD:226572	42/62 (68%)
		Cation_ATPase_C	872..1044	CDD:279079	43/216 (20%)
ATP1A1	NP_000692.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..39		11/55 (20%)
		ATPase-IIC_X-K	30..1023	CDD:273445	301/1079 (28%)
		Phosphoinositide-3 kinase binding. /evidence=ECO:0000250	82..84		0/1 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	216..235		9/20 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	1	1.010	-	-		D100699at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.930