DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SPoCk and PMCA

DIOPT Version :9

Sequence 1:	NP_001262220.1	Gene:	SPoCk / 40495	FlyBaseID:	FBgn0052451	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	NP_001014689.3	Gene:	PMCA / 43787	FlyBaseID:	FBgn0259214	Length:	1255	Species:	Drosophila melanogaster

Alignment Length:	1173	Identity:	300/1173 - (25%)
Similarity:	500/1173 - (42%)	Gaps:	331/1173 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 NGNIIQTGLTLTP----------EMLLSTSESSTHSASEVAGRLQVDVRTGLKWTEA--KYRAKI 142
            :|...|.|::|..          |.::..:|:.  ...|:..:|......||..::|  ::|.:.
  Fly     5 DGRPAQYGISLKQLRELMEHRGREGVMKIAENG--GIHELCKKLYTSPNEGLSGSKADEEHRRET 67

  Fly   143 IGHNELLLVAEDP------TWKKYIEQFRNPLILLLLGSALVSVIMKQF----DDA--------- 188
            .|.|  ::..:.|      .|    |..::..:::|..:||||:.:..:    :||
  Fly    68 FGSN--VIPPKPPKTFLTLVW----EALQDVTLIILEVAALVSLGLSFYKPADEDAPVLQEEEEH 126

  Fly   189 ------VSITIAILIVVTVAFIQEYRSEKSLEELKKLVPPECH---CLREGRLDTFLARELVPGD 244
                  ::|.|::::||.|....:|..|:....|:..:..| |   .:|.|.:......:::.||
  Fly   127 HGWIEGLAILISVIVVVIVTAFNDYSKERQFRGLQNRIEGE-HKFSVIRGGEVCQISVGDILVGD 190

  Fly   245 IVHLNVGDRVPADVRLFEAVDLSIDESSFTGETEPARKITDV---LLNNTNVKDHSNMKNIAFMG 306
            |..:..||.:|||..|.::.||.:||||.|||::..:|..||   :|:.|:|.:
  Fly   191 IAQVKYGDLLPADGCLIQSNDLKVDESSLTGESDHVKKGPDVDPMVLSGTHVME----------- 244

  Fly   307 TLVRCGNGKGIVVSTGERSEFGEVFKMMQA----------------------------------- 336
                 |:||.:|.:.|..|:.|.:|.::.|
  Fly   245 -----GSGKMVVTAVGVNSQAGIIFTLLGAAVDEQEAEIKKMKKEAKRANKQKNLTGENDGRSQI 304

  Fly   337 --EEAP------------------------------------KTPLQKSMDILGAQLSF--YSFL 361
              .:||                                    |:.||..:..|..|:.:  .:..
  Fly   305 KGSQAPSQRETVTSEITKSESEGNHLPQSSSSGAAETGHKKEKSVLQAKLTKLAIQIGYAGSTIA 369

  Fly   362 IIGVIMLL-------GWLQGKP--------LSEMFNISVSLAVAAIPEGLPIVVTVTLALGVMRM 411
            ::.||:|:       ..:..||        |.:...|.|::.|.|:|||||:.||::||..|.:|
  Fly   370 VLTVIILIIQFCIKTFVIDEKPWKNTYANNLVKHLIIGVTVLVVAVPEGLPLAVTLSLAYSVKKM 434

  Fly   412 AKRNSIVKKLPTVETLGCVNVICSDKTGTLTKNEMTATIIITSDGYMADVTGAGYNDQGEIHIRH 476
            .|.|::|:.|...||:|....||||||||||.|.||..                   |..|..:.
  Fly   435 MKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVV-------------------QSYICEKL 480

  Fly   477 CN---NVEMAKTNITNLLEIGAVCNNAYIQN-------GTL---LGQPTEGALVAVAMKNGM--- 525
            |.   .:.....::.||:.:|...|:||..|       |.|   :|..||.||:......|:
  Fly   481 CKVLPTLSDIPQHVGNLITMGISVNSAYTSNIMAGHNPGDLPIQVGNKTECALLGFVQGLGVKYQ 545

  Fly   526 ----YATAENYVRIQEYPFSSEQKMMAVKCIHKYNNNKEEIFFAKGALETLLPQCTKYQFGTQTV 586
                ..|.:.:.|:  |.|:|.:|.|.. .|.:.|....  .:.|||.|.::.:|. :.:|.:..
  Fly   546 SIRDEITEDKFTRV--YTFNSVRKSMGT-VIPRPNGGYR--LYTKGASEIIMKKCA-FIYGHEGT 604

  Fly   587 --PLTKQNEAEFLAEAYE-IGRKGLRVLALA-----KGRS-------------------MQDLIY 624
              ..|:..:...:.|..| :...|||.:::|     .|::                   |.:|..
  Fly   605 LEKFTRDMQERLIREVIEPMACDGLRTISVAYRDFVPGKAAINEVHIDGEPNWDDEENIMTNLTC 669

  Fly   625 CGLVGITDPPRPLVRESIEMLMQSGVRVKMVTGDAQETALAIDPSRRLQAVPTHAIPAWPTAGGV 689
            ..:|||.||.||.|.::|....::|:.|:|||||...||.:|
  Fly   670 LCVVGIEDPVRPEVPDAIRKCQRAGITVRMVTGDNINTARSI----------------------- 711

  Fly   690 PLCSASACCSTNCLENAMKEIYLTALAQQGLPLVTANLIGIDTIHHQTLSGQEMDQ--------M 746
                ||.|                     |:.....:.:        .|.|:|.::        :
  Fly   712 ----ASKC---------------------GILRPNDDFL--------ILEGKEFNRRIRDSNGDI 743

  Fly   747 NEHQLDKVANNVSVFYRVSPRHKLEIVK-----SLQRSGNIVGMTGDGVNDGVALKKADIGIAMG 806
            .:|.:|||...:.|..|.||..|..:||     ::..:..:|.:||||.|||.||||||:|.|||
  Fly   744 QQHLIDKVWPKLRVLARSSPTDKYTLVKGIIDSTVSENREVVAVTGDGTNDGPALKKADVGFAMG 808

  Fly   807 KNGTDVCKEAADMILVNDDFHTIIAAIEEGKGIFYNIRNFVRFQLSTSIAA--LALIALATLMDI 869
            ..||||.|||:|:||.:|:|.:|:.|:..|:.::.:|..|::|||:.::.|  :|.|....:.|
  Fly   809 IAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSIAKFLQFQLTVNVVAVIVAFIGACAVQD- 872

  Fly   870 ANPLNAMQILWINIIMDGPPAQSLGVEPVDHDVLKQKPRNVKQPMITKSVVVNVL---LSASIIV 931
             :||.|:|:||:|:|||...:.:|..|....|:|.:||....:|:|:::::.|:|   |...||:
  Fly   873 -SPLKAVQMLWVNLIMDTLASLALATEFPTPDLLLRKPYGRTKPLISRTMMKNILGQALYQLIII 936

  Fly   932 LGTLWV----FQREMADG---TLGKTKRDTTMTFTCFVFFDMFNALSCRS--QTKSVFTIGLTTN 987
            .|.|:|    ...|...|   ..|.|:. .|:.|..||...:||.::.|.  ..::|.. ||.||
  Fly   937 FGLLFVGDVILDIESGRGQELNAGPTQH-FTIIFNTFVMMTLFNEINARKIHGQRNVIE-GLLTN 999

  Fly   988 RMFLLAVAFSIIGQMLVVYFPPLQMVFQTEALT----PYDIFF-LVSLTSSVLVVS-------EI 1040
            .:|.....|::|.|:|::.:.  :|.|.|:|||    .:.||| :.:|....|:.|       :|
  Fly  1000 PIFYTIWIFTMISQVLIIQYG--KMAFSTKALTLDQWLWCIFFGIGTLVWGQLITSVPTRKLPKI 1062

  Fly  1041 KKW 1043
            ..|
  Fly  1063 LSW 1065

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPoCk	NP_001262220.1	ATPase-IIA2_Ca	110..1049	CDD:130585	295/1143 (26%)
		Cation_ATPase_N	112..179	CDD:279080	14/74 (19%)
		E1-E2_ATPase	191..425	CDD:278548	77/329 (23%)
		Cation_ATPase	496..579	CDD:289987	26/99 (26%)
		COG4087	<760..823	CDD:226572	35/67 (52%)
		Cation_ATPase_C	872..1044	CDD:279079	61/196 (31%)
PMCA	NP_001014689.3	ATPase-IIB_Ca	1..1057	CDD:273668	298/1163 (26%)
		Cation_ATPase_N	36..104	CDD:279080	14/75 (19%)
		E1-E2_ATPase	172..448	CDD:278548	67/291 (23%)
		Cation_ATPase	505..598	CDD:289987	26/98 (27%)
		HAD_like	676..807	CDD:119389	49/186 (26%)
		Cation_ATPase_C	873..1051	CDD:279079	57/181 (31%)
		ATP_Ca_trans_C	1096..1142	CDD:289209
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438611
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840