DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SPoCk and Atp2b4

DIOPT Version :9

Sequence 1:	NP_001262220.1	Gene:	SPoCk / 40495	FlyBaseID:	FBgn0052451	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	XP_011246340.1	Gene:	Atp2b4 / 381290	MGIID:	88111	Length:	1239	Species:	Mus musculus

Alignment Length:	1073	Identity:	279/1073 - (26%)
Similarity:	454/1073 - (42%)	Gaps:	273/1073 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 STSESSTH--SASEVAGRLQVDVRTGLKWTEA--KYRAKIIGHNELLLVAEDP-TWKKYI-EQFR 165
            :.::.|.|  ...|:..||:.....||....|  :.|..:.|.|  ::..:.| |:.:.: |..:
Mouse    40 AVAQISAHYGGVQEICTRLKTSPIEGLSGNPADLEKRRLVFGKN--VIPPKRPKTFLELVWEALQ 102

  Fly   166 NPLILLLLGSALVSVIMKQFD---------------------------DAVSITIAILIVVTVAF 203
            :..:::|..:|::|:::..:.                           :..:|..:::|||.|..
Mouse   103 DVTLIILEIAAIISLVLSFYRPPGGDNEICGHIASSPEEEEEGETGWIEGAAILASVIIVVLVTA 167

  Fly   204 IQEYRSEKSLEELKKLVPPE--CHCLREGRLDTFLARELVPGDIVHLNVGDRVPADVRLFEAVDL 266
            ..::..||....|:..:..|  ...:|.|:|......|:|.|||..:..||.:|||..|.:..||
Mouse   168 FNDWSKEKQFRGLQSRIELEQKFSIIRNGQLIQLPVAEIVVGDIAQIKYGDLLPADGILIQGNDL 232

  Fly   267 SIDESSFTGETEPARKITD---VLLNNTNVKDHSNMKNIAFMGTLVRCGNGKGIVVSTGERSEFG 328
            .|||||.|||::..:|..|   :||:.|:|.:                |:|:.:|.:.|..|:.|
Mouse   233 KIDESSLTGESDHVKKTLDKDPMLLSGTHVME----------------GSGRMVVTAVGVNSQTG 281

  Fly   329 EVFKMMQAEE---------------AP-------------------------------------- 340
            .:|.::.|.|               ||
Mouse   282 IIFTLLGASEEEDDDDKKKKGKKQGAPENRNKAKTQDGVALEIQPLNSQEGLDSEDKEKKIARIP 346

  Fly   341 ---KTPLQKSMDILGAQLS----FYSFLIIGVIMLL-----------GWL-QGKPL-----SEMF 381
               |:.||..:..|..|:.    ..|.|.:.:::|.           .|| :..|:     .:.|
Mouse   347 KKEKSVLQGKLTRLAVQIGKAGLIMSVLTVVILILYFVVDNFVIQRREWLPECTPVYIQYFVKFF 411

  Fly   382 NISVSLAVAAIPEGLPIVVTVTLALGVMRMAKRNSIVKKLPTVETLGCVNVICSDKTGTLTKNEM 446
            .|.|::.|.|:|||||:.||::||..|.:|.|.|::|:.|...||:|....||||||||||.|.|
Mouse   412 IIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRM 476

  Fly   447 TATIIITSDGYMADVTGAGYNDQGEIHIRHCNNVEMAKTNITNLLEIGAVCNNAYI-------QN 504
            |..     ..|:           |..|.|.....::....:..|:..|...|.||.       :.
Mouse   477 TVV-----QAYI-----------GGTHYRQIPQPDVFPPKVLELIVNGISINCAYTSKIQPPEKE 525

  Fly   505 GTL---LGQPTE-GALVAVAMKNGMYATAENYVRIQE----YPFSSEQKMMAVKCIHKYNNNKEE 561
            |.|   :|..|| |.|..|......|....|.|..::    |.|:|.:|.|:. .|.|......
Mouse   526 GGLPRQVGNKTECGLLGFVTDLKQDYQAVRNEVPEEKLFKVYTFNSVRKSMST-VIRKPEGGFR- 588

  Fly   562 IFFAKGALETLLPQCTKYQFGTQTVPLTKQNEAE---------FLAEAYE-IGRKGLRVLALA-- 614
             .|:|||.|.:|.:|.:.        |.|:.|.:         .:....| :..:|||.:.||
Mouse   589 -MFSKGASEIMLRRCDRI--------LNKEGEIKSFRSKDRDNMVRNVIEPMASEGLRTICLAYR 644

  Fly   615 -----------KGRSMQDLIYCGLVGITDPPRPLVRESIEMLMQSGVRVKMVTGDAQETALAIDP 668
                       :|..:..||...:|||.||.||.|.::|....::|:.|:|||||...||.||
Mouse   645 DFDGTEPSWDIEGEILTSLICIAVVGIEDPVRPEVPDAIAKCKRAGITVRMVTGDNVNTARAI-- 707

  Fly   669 SRRLQAVPTHAIPAWPTAGGVPLCSASACCSTNCLENAMKEIYLTALAQQGLPLVTANLIGIDTI 733
                                          :|.|                |:.....:.:.::..
Mouse   708 ------------------------------ATKC----------------GILTPKDDFLCLEGK 726

  Fly   734 HHQTLSGQEMDQMNEHQLDKVANNVSVFYRVSPRHKLEIVKSL-------QRSGNIVGMTGDGVN 791
            ...:|...|..::.:.:|||:...:.|..|.||..|..:||.:       ||  .:|.:||||.|
Mouse   727 EFNSLIRNEKGEVEQEKLDKIWPKLRVLARSSPTDKHTLVKGIIDSTAGEQR--QVVAVTGDGTN 789

  Fly   792 DGVALKKADIGIAMGKNGTDVCKEAADMILVNDDFHTIIAAIEEGKGIFYNIRNFVRFQLSTSIA 856
            ||.||||||:|.|||..||||.|||:|:||.:|:|.:|:.|:..|:.::.:|..|::|||:.::.
Mouse   790 DGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVV 854

  Fly   857 ALALIALATLMDIANPLNAMQILWINIIMDGPPAQSLGVEPVDHDVLKQKPRNVKQPMITKSVVV 921
            |:.:......:...:||.|:|:||:|:|||...:.:|..||....:|:::|....:|:|:::::.
Mouse   855 AVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTESLLRRRPYGRNKPLISRTMMK 919

  Fly   922 NVLLSASIIVLGTLWVFQREMADGTL------------GKTKRDTTMTFTCFVFFDMFNALSCRS 974
            |:|..|   |...|.||....|..||            ....:..|:.|..||...:||.::.|.
Mouse   920 NILGHA---VYQLLIVFLLVFAGDTLFDIDSGRKAPLNSPPSQHYTIVFNTFVLMQLFNEINARK 981

  Fly   975 --QTKSVFTIGLTTNRMFLLAVAFSIIGQMLVV 1005
              ..|:||. |:..|.:|...|..:...|:::|
Mouse   982 IHGEKNVFA-GVYRNIIFCTVVLGTFFCQIMIV 1013

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPoCk	NP_001262220.1	ATPase-IIA2_Ca	110..1049	CDD:130585	279/1070 (26%)
		Cation_ATPase_N	112..179	CDD:279080	16/72 (22%)
		E1-E2_ATPase	191..425	CDD:278548	81/315 (26%)
		Cation_ATPase	496..579	CDD:289987	28/97 (29%)
		COG4087	<760..823	CDD:226572	37/69 (54%)
		Cation_ATPase_C	872..1044	CDD:279079	43/148 (29%)
Atp2b4	XP_011246340.1	ATPase-IIB_Ca	16..1053	CDD:273668	279/1073 (26%)
Atp2b4	XP_011246340.1	ATP_Ca_trans_C	1090..1169	CDD:372101
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010