DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SPoCk and atp2b1a

DIOPT Version :9

Sequence 1:	NP_001262220.1	Gene:	SPoCk / 40495	FlyBaseID:	FBgn0052451	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	XP_021330641.1	Gene:	atp2b1a / 378746	ZFINID:	ZDB-GENE-030925-29	Length:	1266	Species:	Danio rerio

Alignment Length:	973	Identity:	259/973 - (26%)
Similarity:	425/973 - (43%)	Gaps:	248/973 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   187 DAVSITIAILIVVTVAFIQEYRSEKSLEELKKLVPPE--CHCLREGRLDTFLARELVPGDIVHLN 249
            :..:|.::::.||.|....::..||....|:..:..|  ...:|.|::......|:|.|||..:.
Zfish   150 EGAAILLSVVCVVLVTAFNDWSKEKQFRGLQSRIEQEQKFSVVRGGQVIQIHVAEIVVGDIAQIK 214

  Fly   250 VGDRVPADVRLFEAVDLSIDESSFTGETEPARKITD---VLLNNTNVKDHSNMKNIAFMGTLVRC 311
            .||.:|||..|.:..||.|||||.|||::..:|..|   :||:.|:|.:
Zfish   215 YGDLLPADGILIQGNDLKIDESSLTGESDHVKKSLDKDAMLLSGTHVME---------------- 263

  Fly   312 GNGKGIVVSTGERSEFGEVFKMMQA---------------------------------------- 336
            |:||.:|.:.|..|:.|.:|.::.|
Zfish   264 GSGKIVVTAVGVNSQTGIIFTLLGAGEDDDDEEEKEKKKEKERKKEKKNKKQDGSVENRKKAKAQ 328

  Fly   337 ------------------EEAPKTPL-QKSMDIL--------------GAQLSFYSFLIIGVIML 368
                              ||..|..| :|...:|              |..:|..:.:|:.|:.:
Zfish   329 DGAAMEMQPLNSDEGADGEEKRKANLPKKEKSVLQGKLTKLAVQIGKAGLLMSAITVIILVVLFV 393

  Fly   369 LG--WLQGKP------------LSEMFNISVSLAVAAIPEGLPIVVTVTLALGVMRMAKRNSIVK 419
            :.  |:...|            ..:.|.|.|::.|.|:|||||:.||::||..|.:|.|.|::|:
Zfish   394 VDTFWVDKIPWDSGCIPIYIQFFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVR 458

  Fly   420 KLPTVETLGCVNVICSDKTGTLTKNEMTATIIITSDGYMADVTGAGYNDQGEIHIRHCNNVEMAK 484
            .|...||:|....||||||||||.|.||...:..:|.                |.|.....::..
Zfish   459 HLDACETMGNATAICSDKTGTLTMNRMTVVQVFIADK----------------HYRKVPEPDVVP 507

  Fly   485 TNITNLLEIGAVCNNAYI-------QNGTL---LGQPTEGALVAVAM---KNGMYATAENYVRIQ 536
            .:..:||.:|...|.||.       :.|.|   :|..||.||:..|:   |:  |....|.:..:
Zfish   508 ASTMDLLIVGISVNCAYTTKIMSPEKEGGLNRQVGNKTECALLGFALDLKKD--YQAVRNEIPEE 570

  Fly   537 E----YPFSSEQKMMAVKCIHKYNNNKEEIFFAKGALETLLPQCTKYQFGTQTVPLTKQNEAEFL 597
            :    |.|:|.:|.|:.  :.| |::.....|:|||.|.||.:|.|....|....:.:..:.:.:
Zfish   571 KLYKVYTFNSVRKSMST--VLK-NDDGSYRMFSKGASEILLKKCFKILTSTGEAKVFRPRDRDDM 632

  Fly   598 AEAY--EIGRKGLRVLALA-------KGRSMQD--------LIYCGLVGITDPPRPLVRESIEML 645
            .:..  .:..:|||.:.||       :|....|        |....:|||.||.||.|.::|...
Zfish   633 VKRVIEPMASEGLRTICLAYRDFPASEGEPDWDNEADILTRLTCVCVVGIEDPVRPEVPDAIRKC 697

  Fly   646 MQSGVRVKMVTGDAQETALAIDPSRRLQAVPTHAIPAWPTAGGVPLCSASACCSTNCLENAMKEI 710
            .::|:.|:|||||...||.||                                :|.|
Zfish   698 QRAGITVRMVTGDNLNTARAI--------------------------------ATKC-------- 722

  Fly   711 YLTALAQQGLPLVTANLIGIDTIHHQTLSGQEMD--------QMNEHQLDKVANNVSVFYRVSPR 767
               .:.|          :|.|.:   .|.|:|.:        ::.:.::||:...:.|..|.||.
Zfish   723 ---GILQ----------VGDDFL---CLEGKEFNRRIRNEKGEIEQERIDKIWPKLRVLARSSPT 771

  Fly   768 HKLEIVKSL-------QRSGNIVGMTGDGVNDGVALKKADIGIAMGKNGTDVCKEAADMILVNDD 825
            .|..:||.:       ||  .:|.:||||.|||.||||||:|.|||..||||.|||:|:||.:|:
Zfish   772 DKHTLVKGIIDSTVVEQR--QVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDN 834

  Fly   826 FHTIIAAIEEGKGIFYNIRNFVRFQLSTSIAALALIALATLMDIANPLNAMQILWINIIMDGPPA 890
            |.:|:.|:..|:.::.:|..|::|||:.::.|:.:......:...:||.|:|:||:|:|||...:
Zfish   835 FSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTLAS 899

  Fly   891 QSLGVEPVDHDVLKQKPRNVKQPMITKSVVVNVLLSA--SIIVLGTLWVFQREMADGTLGK---- 949
            .:|..||....:|.:||....:|:|:::::.|:|..|  .:|::.||.....:|.:...|:
Zfish   900 LALATEPPTESLLLRKPYGRNKPLISRTMMKNILGHAVYQLIIIFTLLFAGEKMFNIDSGRYADL 964

  Fly   950 ---TKRDTTMTFTCFVFFDMFNALSCRS--QTKSVFTIGLTTNRMFLLAVAFSIIGQMLVVYF 1007
               .....|:.|..||...:||.::.|.  ..::||. |:..|.:|...|..:.:.|:::|.|
Zfish   965 HAPPSEHYTIVFNTFVMMQLFNEINARKIHGERNVFE-GIFNNMIFCTIVFGTFVIQIVIVQF 1026

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPoCk	NP_001262220.1	ATPase-IIA2_Ca	110..1049	CDD:130585	259/973 (27%)
		Cation_ATPase_N	112..179	CDD:279080
		E1-E2_ATPase	191..425	CDD:278548	78/325 (24%)
		Cation_ATPase	496..579	CDD:289987	29/99 (29%)
		COG4087	<760..823	CDD:226572	37/69 (54%)
		Cation_ATPase_C	872..1044	CDD:279079	42/147 (29%)
atp2b1a	XP_021330641.1	E1-E2_ATPase	10..1064	CDD:332568	259/973 (27%)
atp2b1a	XP_021330641.1	ATP_Ca_trans_C	1105..1191	CDD:315156
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573954
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.940