DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SPoCk and CG6230

DIOPT Version :9

Sequence 1:	NP_001262220.1	Gene:	SPoCk / 40495	FlyBaseID:	FBgn0052451	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	NP_609490.1	Gene:	CG6230 / 34546	FlyBaseID:	FBgn0027582	Length:	1225	Species:	Drosophila melanogaster

Alignment Length:	1059	Identity:	230/1059 - (21%)
Similarity:	404/1059 - (38%)	Gaps:	263/1059 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 STHSASEVAGRLQVDVRTGLKWTEAKYRA-KIIGHNELLLVAEDPTWKK-YIEQFRNPLILLLLG 174
            ||:|:|.           ||:..|...|| :..|:||:.:|.  |.:.: :||:...|..:.
  Fly   207 STYSSSR-----------GLETEEDIKRATQTYGNNEMEMVV--PEFHELFIERATAPFFVF--- 255

  Fly   175 SALVSVIMKQFDD---AVSITIAILIVVTVAFIQEYRSEKSLEELKKL--VPPECHCLREGRLDT 234
             .:.||.:...||   ....|:.:||......:::  ..:::.|::|:  .|...:..|:.:...
  Fly   256 -QVFSVGLWCMDDYWYYSLFTLFMLIAFECTIVKQ--QLRNMSEIRKMGNKPYLIYAFRQNKWRH 317

  Fly   235 FLARELVPGDIVHLNVGDR---VPADVRLFEAVDLSIDESSFTGETEPARKITDVLLNNTNVK-- 294
            ..:.||:|||:|.:.....   ||.|:.:... ...:|||..|||:.|..|.:...|:|.:|:
  Fly   318 LGSDELLPGDLVSITRSQNDNIVPCDLVILRG-SCIVDESMLTGESVPLMKESLESLDNLDVEMD 381

  Fly   295 -DHSNMKNIAFMGTLV-----------RCGNGK--GIVVSTGERSEFGEVFK--MMQAEEAPKTP 343
             :......:.|.||.|           |..:|.  |.|:.||..:..|::.:  :..|..|.:..
  Fly   382 AEGDGKLFVLFGGTKVVQHTAPTKESLRAPDGGCIGYVIRTGFNTSQGKLLRTILFGANRATENN 446

  Fly   344 LQKSMDILGAQLSFYSFLIIGVIMLLG--WLQGKPLSE-----MFNISVSLAVAAIPEGLPIVVT 401
            ::        ..:|.:||::..:....  |::|....|     :|.....:..:.||..|||.:|
  Fly   447 VE--------TFAFIAFLMVFAVAAASYVWVKGSEDPERNRYKLFLECTLILTSIIPPDLPIELT 503

  Fly   402 VTLALGVMRMAKRNSIVKKLPTVETLGCVNVICSDKTGTLTKNEMTATIIITSDGYMAD-VTGAG 465
            :.:...::::.|......:...:...|.|.:.|.||||||           |:|..|.: :.|..
  Fly   504 LAVNTSLIQLTKLFVFCTEPFRIPFAGKVQICCFDKTGTL-----------TTDNLMVEGIAGLA 557

  Fly   466 YNDQGEIHIRHCNNVEMAKTNITNLLEIGAVCNNAYIQNGTLLGQPTEGALVA-----------V 519
            .|..       |..:|.|:.|...:|   |.|::..:.:..|:|.|.|.|.:|           |
  Fly   558 PNGA-------CVPIEKAEGNTVQVL---ACCHSLALLDDGLVGDPLEKATLAAVDWTLTKMDSV 612

  Fly   520 AMKNGMYATAENYVRIQEYPFSSEQKMMAVKCIH--KYNNNKEEIFFAKGALETLLPQCTKYQFG 582
            ..|...:...:   .||.|.|||..|.|:|...|  .|:|..:.|...|||.|.:       |..
  Fly   613 IPKRPQFKPLK---IIQRYHFSSALKRMSVLAGHLIPYSNEVKHIGAVKGAPEVI-------QKM 667

  Fly   583 TQTVPLTKQNEAEFLAEAYEIGRKGLRVLALA----------KGRSMQ------DLIYCGLVGIT 631
            .:.||      |::.....|..|:|.|||||.          :.|.|:      ||.:.|.:.|:
  Fly   668 LREVP------ADYEKVYLEYARRGARVLALGIKDLGTLGAQRVREMKREEVECDLTFAGFLIIS 726

  Fly   632 DPPRPLVRESIEMLMQSGVRVKMVTGDAQETALAIDPSRRLQAVPTHAIPAWPTAGGVPLCSASA 696
            .|.:|..:..|:.|:||..:|.|:|||:..||..:  :|.|:......|...|.
  Fly   727 CPMKPDSKSVIKELIQSSHKVVMITGDSPLTACHV--ARELRFTRKKLIILTPP----------- 778

  Fly   697 CCSTNCLENAMKE--IYLTALAQQGLPLVT----ANLIGIDTIHHQTLSGQEMDQMNEHQ---LD 752
                   |...|.  .:::....|...|.|    ..|..:...|...::|:.:..:.::|   :.
  Fly   779 -------EEDRKNNWSWVSIDGDQSYELDTKPGSKKLSHLLATHDLCITGEGLQYLQQNQPQYMR 836

  Fly   753 KVANNVSVFYRVSPRHKLEIVKSLQRSGNIVGMTGDGVNDGVALKKADIGIAMGKNGTDVCKEAA 817
            ::...::|..|.:|:.|..::..|::.|....|.|||.||..|||.|::|::: .....|.::..
  Fly   837 QLLPQITVCARFAPKQKELVITQLKQLGYCTLMCGDGTNDVGALKHANVGVSL-LTSAPVKRKRT 900

  Fly   818 DMILVNDDFHTIIAAIEEGKGIFYNIRNFVRFQLSTSIAALALIALATLMDIANP---------- 872
            :               ||.:            |.:.:.||:|..|.|.    ||.
  Fly   901 E---------------EEQQ------------QAAANAAAIAAQAQAN----ANQQLTTRERALR 934

  Fly   873 -----LNAMQILWINIIMD---------------GP-PAQSLGVEPVDHDVLKQKPRNVKQPMIT 916
                 ||..|....|.:.|               .| .::|..:..|:|.:.:.:...|....:.
  Fly   935 RRQEHLNQTQARLQNALRDMEEQTMVKLGDASIAAPFTSKSSSIMCVNHIIKQGRCTLVTTLQMF 999

  Fly   917 KSVVVNVLLSA---SIIVLGTLWVFQREMADGTLGKTKRDTTMTF------TCFVFFDMFNALSC 972
            |.:.:|.|:.|   |::.:.              |....||..|.      .||:|......|..
  Fly  1000 KILALNALIQAYCQSVLYID--------------GIKFSDTQATMQGIFIAACFLFITRAKPLKT 1050

  Fly   973 RSQT---KSVFTIGLTTNRMFLLAVAFSIIGQMLV---VYFPP------LQMVFQTEALTPYD-- 1023
            .|:.   .::|.....:..:...||.|..:..:..   :..||      |.:....|..|.||
  Fly  1051 LSKVAPLPNIFNFYTISTILSQFAVHFGTLYYLTSQANILAPPREGKVKLYIDMDAEEKTKYDPN 1115

  Fly  1024 ----IFFLVSLTSSVLVVS 1038
                ..:::.|:..|..::
  Fly  1116 IVSSTVYIICLSLQVATIA 1134

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPoCk	NP_001262220.1	ATPase-IIA2_Ca	110..1049	CDD:130585	230/1059 (22%)
		Cation_ATPase_N	112..179	CDD:279080	17/68 (25%)
		E1-E2_ATPase	191..425	CDD:278548	54/263 (21%)
		Cation_ATPase	496..579	CDD:289987	26/95 (27%)
		COG4087	<760..823	CDD:226572	18/62 (29%)
		Cation_ATPase_C	872..1044	CDD:279079	37/225 (16%)
CG6230	NP_609490.1	P-ATPase-V	109..1193	CDD:273738	230/1059 (22%)
		E1-E2_ATPase	310..515	CDD:278548	47/213 (22%)
		Cation_ATPase	<590..664	CDD:289987	24/76 (32%)
		COG4087	<850..901	CDD:226572	16/51 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438608
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840