Protein Alignment SPoCk and ATP7

DIOPT Version :9

• Sequence 1: NP_001262220.1
• Gene: SPoCk / 40495
• FlyBaseID: FBgn0052451
• Length: 1062
• Species: Drosophila melanogaster
• Sequence 2: NP_001259466.1
• Gene: ATP7 / 32142
• FlyBaseID: FBgn0030343
• Length: 1254
• Species: Drosophila melanogaster
• Alignment Length: 1136
• Identity: 222/1136 - (19%)
• Similarity: 397/1136 - (34%)
• Gaps: 394/1136 - (34%)

  Fly     2 SKTPKPLTS-KRRTSPASP-------GSTVL--------------IESPTTSS---GVRNRRSKI 41
            |.:|.|.:| |:|.:|..|       ||.|.              |...|.:|   .:.....||
  Fly   169 SPSPAPASSPKKRATPTPPPPSYAQNGSAVAIPVEQELLTKCFLHIRGMTCASCVAAIEKHCKKI 233

  Fly    42 KGVDS------------KPNPQRTISHVKDSRAVPQNVKPGKVADMKDCKEPDEDN--------- 85
            .|:||            |.| ...::....::::.:...|.::.|     |||...
  Fly   234 YGLDSILVALLAAKAEVKFN-ANVVTAENIAKSITELGFPTELID-----EPDNGEAEVELEIMG 292

  Fly    86 ------VDQQNGNIIQ-TGLTLTPEMLLS--------TSESSTHSASEVAGRL--QVDVRTGLKW 133
                  |::...:::: .|:|.....||:        |.|:...|..|....|  :..:.||
  Fly   293 MTCASCVNKIESHVLKIRGVTTASVTLLTKRGKFRYITEETGPRSICEAIEALGFEAKLMTG--- 354

  Fly   134 TEAKYRAKIIGHNELLLVAEDPTWKKYIEQFRNPLILLLL--GSALVSVI--MKQFDD------- 187
                 |.| :.||.|       ..|:.|.::||..::.|:  |..:|::|  |.:..|
  Fly   355 -----RDK-MAHNYL-------EHKEEIRKWRNAFLVSLIFGGPCMVAMIYFMLEMSDKGHANMC 406

  Fly   188 ------AVSITIAILIVVTVAF-------IQEYRSEK----SLEELKKLV--------------- 220
                  ::...:..|:...|.|       :|.||:.|    :::.|..:|
  Fly   407 CLVPGLSMENLVMFLLSTPVQFFGGFHFYVQSYRAIKHGTTNMDVLISMVTTISYVYSVAVVIAA 471

  Fly   221 ---------------PPEC-----------HCLREGRLDTFLAR------------ELVP----- 242
                           ||..           | :.:|:....|::            |:.|
  Fly   472 VLLEQNSSPLTFFDTPPMLLIFISLGRWLEH-IAKGKTSEALSKLLSLKAADALLVEISPDFDII 535

  Fly   243 ------------GDIVHLNVGDRVPADVRLFEAVDLSIDESSFTGETEPARKITDVLLNNTNVKD 295
                        |||:.:..|.:||.|.::... ..|.|||..|||:.|..|
  Fly   536 SEKVISVDYVQRGDILKVIPGAKVPVDGKVLYG-HSSCDESLITGESMPVAK------------- 586

  Fly   296 HSNMKNIAFMGTLVRCGNGKGIVV----STGERSEFGEVFKMMQAEEAPKTPLQKSMD-ILGAQL 355
               .|....:|..:   |..|:::    .|||.:...::.::::..:..|.|:|:..| |.|..:
  Fly   587 ---RKGSVVIGGSI---NQNGVLLVEATHTGENTTLAQIVRLVEEAQTSKAPIQQLADRIAGYFV 645

  Fly   356 SFYSFLIIGVIMLLGWL---QGKP-------------------LSEMFNISVSLAVAAIPEGL-- 396
            .|  .:::..|.|:.|:   ...|                   :|..|..::|:...|.|..|
  Fly   646 PF--VVVVSSITLIAWIIIGFSNPNLVPVAMEHKMHMDQNTIIVSYAFKCALSVLAIACPCALGL 708

  Fly   397 --PIVVTVTLALGVMRMAKRNSIVKKLPTVETLGCVNVICSDKTGTLTK-NEMTA--TIIITSD- 455
              |..|.|....|    |....:||....:|....|..:..|||||:|. ..||:  |:.:|:.
  Fly   709 ATPTAVMVATGTG----AINGVLVKGATALENAHKVKTVVFDKTGTITHGTPMTSKVTLFVTAQV 769

  Fly   456 -GYMADVTGAGYNDQGEIHIRHCNNVEMAKTNITNLLEIGAVCNNAYIQNGTLLGQPTEGALVAV 519
             .....:|..|..:|...|......|..||    ::|.:||.     .|.|: .|:.:....|..
  Fly   770 CSLARALTIVGAAEQNSEHPIASAIVHFAK----DMLNVGAT-----PQAGS-FGKSSHFQAVPG 824

  Fly   520 AMKNGMYATAENYVRIQEYPFSSEQKMMAVKCIHKYNNNKEEIFFAKGA-LETLLPQCT---KYQ 580
            .   |:..|..||.:......::: :::..:.:|: .:.:..:....|| :|.||||.:   ..:
  Fly   825 C---GIRVTVSNYEQTLRQACNAD-RIINYENLHR-THPQGSVPVDNGASIEHLLPQRSVRKSME 884

  Fly   581 FGTQTV--PLTKQNEAEFLAEAYEIGRKGLRVL----------ALAKGRSMQD-----------L 622
            ...|.:  .|..:.|.|.|.:...|....:.||          |:.....:.|           .
  Fly   885 LNNQQLLSDLVLEPEEELLTDQKIIDSPEILVLIGNREWMERNAIEVPLEISDCMTHEERKGHTA 949

  Fly   623 IYCGLVG-------ITDPPRPLVRESIEMLMQSGVRVKMVTGDAQETALAIDPSRRLQAVPTHAI 680
            :.|.|.|       ::|..:|....::..|.:.|:.|.::|||.:.||.:|
  Fly   950 VLCALNGQLVCMFAVSDMVKPEAHLAVYTLKRMGIDVVLLTGDNKNTAASI-------------- 1000

  Fly   681 PAWPTAGGVPLCSASACCSTNCLENAMKEIYLTALAQQGLPLVTANLIGIDTIHHQTLSGQEMDQ 745
                                                        |..:||.|::.:.|
  Fly  1001 --------------------------------------------AREVGIRTVYAEVL------- 1014

  Fly   746 MNEHQLDKVANNVSVFYRVSPRHKLEIVKSLQRSGNIVGMTGDGVNDGVALKKADIGIAMGKNGT 810
                                |.||:..::.:|.:|..|.|.||||||..||.:||:||.:.. ||
  Fly  1015 --------------------PSHKVAKIQRIQANGIRVAMVGDGVNDSPALAQADVGITIAA-GT 1058

  Fly   811 DVCKEAADMILVNDDFHTIIAAIEEGKGIFYNIR---------NFVRFQLSTSI-AALALIALAT 865
            ||..||:|::|:.:|...::|.::..:.....||         |.:...|::.: |......|..
  Fly  1059 DVAAEASDIVLMRNDLLDVVACLDLSRCTVRRIRYNFFFASMYNLLGIPLASGLFAPYGFTLLPW 1123

  Fly   866 LMDIANPLNAMQILWINIIMD---GPPAQSL 893
            :..:|...:::.::..::::.   .|.|::|
  Fly  1124 MASVAMAASSVSVVCSSLLLKMYRKPTAKTL 1154

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SPoCk	NP_001262220.1	ATPase-IIA2_Ca	110..1049	CDD:130585	190/967 (20%)
		Cation_ATPase_N	112..179	CDD:279080	16/70 (23%)
		E1-E2_ATPase	191..425	CDD:278548	63/345 (18%)
		Cation_ATPase	496..579	CDD:289987	16/86 (19%)
		COG4087	<760..823	CDD:226572	27/62 (44%)
		Cation_ATPase_C	872..1044	CDD:279079	3/25 (12%)
ATP7	NP_001259466.1	HMA	16..78	CDD:238219
		HMA	97..159	CDD:238219
		HMA	214..274	CDD:238219	11/60 (18%)
		ZntA	285..1131	CDD:225127	193/989 (20%)
		HMA	287..350	CDD:238219	10/62 (16%)
		E1-E2_ATPase	489..735	CDD:278548	52/272 (19%)
		COG4087	<984..1085	CDD:226572	41/186 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438601
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840