DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SPoCk and Atp2b4

DIOPT Version :9

Sequence 1:	NP_001262220.1	Gene:	SPoCk / 40495	FlyBaseID:	FBgn0052451	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	XP_038946574.1	Gene:	Atp2b4 / 29600	RGDID:	621305	Length:	1241	Species:	Rattus norvegicus

Alignment Length:	1071	Identity:	278/1071 - (25%)
Similarity:	459/1071 - (42%)	Gaps:	270/1071 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 STSESSTH--SASEVAGRLQVDVRTGLKWTEA--KYRAKIIGHNELLLVAEDP------TWKKYI 161
            :.::.|.|  |..|:..||:.....||....|  :.|..:.|.|  ::..:.|      .|
  Rat    40 AVTQISAHYGSVQEICARLKTSPVEGLSGNPADLEKRRLVFGKN--MIPPKKPKTFLELVW---- 98

  Fly   162 EQFRNPLILLLLGSALVSVIMKQFD---------------------------DAVSITIAILIVV 199
            |..::..:::|..:|::|:::..:.                           :..:|..:::|||
  Rat    99 EALQDVTLIILEIAAIISLVLSFYRPPGGENEICGHIVSNPEEDEEGETGWIEGAAILASVIIVV 163

  Fly   200 TVAFIQEYRSEKSLEELKKLVPPE--CHCLREGRLDTFLARELVPGDIVHLNVGDRVPADVRLFE 262
            .|....::..||....|:..:..|  ...:|.|:|......|:|.|||..:..||.:|||..|.:
  Rat   164 FVTAFNDWSKEKQFRGLQSRIELEQKFSIIRNGQLIQLPVAEIVVGDIAQVKYGDLLPADGILIQ 228

  Fly   263 AVDLSIDESSFTGETEPARKITD---VLLNNTNVKDHSNMKNIAFMGTLVRCGNGKGIVVSTGER 324
            ..||.|||||.|||::..:|..|   :||:.|:|.:                |:|:.:|.:.|..
  Rat   229 GNDLKIDESSLTGESDHVKKTLDKDPMLLSGTHVME----------------GSGRMVVTAVGIN 277

  Fly   325 SEFGEVFKMMQAEE-------------------------------------------------AP 340
            |:.|.:|.::.|.|                                                 |.
  Rat   278 SQTGIIFTLLGANEEEDDEKKKKGKKQGVSENRNKAKTQDGVALEIQPLNSQEGLDSEEKEKKAS 342

  Fly   341 KTP------LQKSMDILGAQ-------LSFYSFLII--------GVIMLLGWL-QGKPL-----S 378
            |.|      ||..:..|..|       :|..:.||:        .||....|| :..|:     .
  Rat   343 KGPKKEKSVLQGKLTRLAVQIGKAGLIMSILTVLILILYFVVDNFVIQRRAWLPECTPVYIQYFV 407

  Fly   379 EMFNISVSLAVAAIPEGLPIVVTVTLALGVMRMAKRNSIVKKLPTVETLGCVNVICSDKTGTLTK 443
            :.|.|.|::.|.|:|||||:.||::||..|.:|.|.|::|:.|...||:|....||||||||||.
  Rat   408 KFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTM 472

  Fly   444 NEMTATIIITSDGYMADVTGAGYNDQGEIHIRHCNNVEMAKTNITNLLEIGAVC-NNAYI----- 502
            |.||..     ..|:           |..|.|.....:....|:.:|: :.::| |:||.
  Rat   473 NRMTVV-----QAYI-----------GGTHYRQIPKPDDLPPNVLDLI-VNSICINSAYTSKILP 520

  Fly   503 --QNGTL---LGQPTEGALVAV---------AMKNGMYATAENYVRIQEYPFSSEQKMMAVKCIH 553
              :.|.|   :|..||..|:..         |:::.|  ..|...::  |.|:|.:|.|:. .|.
  Rat   521 PEKEGGLPRQVGNKTECGLLGFVTDLKQDYQAVRSEM--PEEKLFKV--YTFNSVRKSMST-VIR 580

  Fly   554 KYNNNKEEIFFAKGALETLLPQCTKY---QFGTQTVPLTKQNEAEFLAEAYE-IGRKGLRVLALA 614
            |......  .|:|||.|.:|.:|.:.   :.|  .||...::....:....| :..:|||.:.:|
  Rat   581 KPEGGFR--VFSKGASEIMLRKCDRILNKEGG--IVPFKTKDRDNMVRNVIEPMASEGLRTIGIA 641

  Fly   615 -------------KGRSMQDLIYCGLVGITDPPRPLVRESIEMLMQSGVRVKMVTGDAQETALAI 666
                         :......|:...:|||.||.||.|.::|....::|:.|:|||||...||.||
  Rat   642 YRDFDGEEPSWENENEIFTGLVCIAVVGIEDPVRPEVPDAINKCKRAGITVRMVTGDNVNTARAI 706

  Fly   667 DPSRRLQAVPTHAIPAWPTAGGVPLCSASACCSTNCLENAMKEIYLTALAQQGLPLVTANLIGID 731
                                            :|.|                |:.....:.:.::
  Rat   707 --------------------------------ATKC----------------GILTPGDDFLCLE 723

  Fly   732 TIHHQTLSGQEMDQMNEHQLDKVANNVSVFYRVSPRHKLEIVKSLQRSG-----NIVGMTGDGVN 791
            ......|...|..::.:.:||||...:.|..|.||..|..:||.:..|.     .:|.:||||.|
  Rat   724 GKEFNRLIRNEKGEVEQEKLDKVWPRLRVLARSSPTDKHTLVKGIIDSNIGEQRQVVAVTGDGTN 788

  Fly   792 DGVALKKADIGIAMGKNGTDVCKEAADMILVNDDFHTIIAAIEEGKGIFYNIRNFVRFQLSTSIA 856
            ||.||||||:|.|||..||||.|||:|:||.:|:|.:|:.|:..|:.::.:|..|::|||:.::.
  Rat   789 DGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVV 853

  Fly   857 ALALIALATLMDIANPLNAMQILWINIIMDGPPAQSLGVEPVDHDVLKQKPRNVKQPMITKSVVV 921
            |:.:......:...:||.|:|:||:|:|||...:.:|..||....:|:::|....:|:|:::::.
  Rat   854 AVIVAFSGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTDSLLRRRPYGRNKPLISRTMMK 918

  Fly   922 NVLLSASIIVLGT--LWVFQRE-MADGTLGK-------TKRDTTMTFTCFVFFDMFNALSCRS-- 974
            |: |..::..||.  |.||..: :.|...|:       ..:..|:.|..||...:||.::.|.
  Rat   919 NI-LGHAVYQLGIVFLLVFAGDKLFDIDSGRKAPLNSPPSQHYTIVFNTFVLMQLFNEINSRKIH 982

  Fly   975 QTKSVFTIGLTTNRMFLLAVAFSIIGQMLVV 1005
            ..|:||. |:..|.:|...|..:...|:|:|
  Rat   983 GEKNVFA-GVYRNIIFCSVVLGTFFCQILIV 1012

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPoCk	NP_001262220.1	ATPase-IIA2_Ca	110..1049	CDD:130585	278/1068 (26%)
		Cation_ATPase_N	112..179	CDD:279080	17/76 (22%)
		E1-E2_ATPase	191..425	CDD:278548	83/314 (26%)
		Cation_ATPase	496..579	CDD:289987	27/102 (26%)
		COG4087	<760..823	CDD:226572	36/67 (54%)
		Cation_ATPase_C	872..1044	CDD:279079	43/146 (29%)
Atp2b4	XP_038946574.1	ATPase-IIB_Ca	16..1052	CDD:273668	278/1071 (26%)
Atp2b4	XP_038946574.1	ATP_Ca_trans_C	1089..1172	CDD:403580
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010