Protein Alignment SPoCk and Atp2b3

DIOPT Version :10

• Sequence 1: NP_001262220.1
• Gene: SPoCk / 40495
• FlyBaseID: FBgn0052451
• Length: 1062
• Species: Drosophila melanogaster
• Sequence 2: XP_038955468.1
• Gene: Atp2b3 / 29599
• RGDID: 621304
• Length: 1330
• Species: Rattus norvegicus
• Alignment Length: 1216
• Identity: 292/1216 - (24%)
• Similarity: 469/1216 - (38%)
• Gaps: 380/1216 - (31%)

  Fly    47 KPNPQRTISHVKDSRAVPQNVKPGKVADMKDCKEPDEDNVDQQNGNIIQTGLTLTPEMLLSTSES 111
            ||..||.:.||......        :|:::...|                   |.....|...:.
  Rat    14 KPQQQREVPHVGGFGCT--------LAELRSLME-------------------LRGAEALQKIQE 51

  Fly   112 STHSASEVAGRLQVDVRTGL--KWTEAKYRAKIIGHNELLLVAEDP-TWKKYI-EQFRNPLILLL 172
            :....|.:..||:.....||  ...:.:.|.:|.|.|  .:..:.| |:.:.: |..::..:::|
  Rat    52 AYGDVSGLCRRLKTSPTEGLADNTNDLEKRRQIYGQN--FIPPKQPKTFLQLVWEALQDVTLIIL 114

  Fly   173 LGSALVSVIMKQFD---------------------------DAVSITIAILIVVTVAFIQEYRSE 210
            ..:|:||:.:..:.                           :..:|.::::.||.|....::..|
  Rat   115 EVAAIVSLGLSFYAPPGEESEACGNVSGGAEDEGEAEAGWIEGAAILLSVICVVLVTAFNDWSKE 179

  Fly   211 KSLEELKKLVPPE--CHCLREGRLDTFLARELVPGDIVHLNVGDRVPADVRLFEAVDLSIDESSF 273
            |....|:..:..|  ...:|.|:|.......||.|||..:..||.:|||..|.:..||.|||||.
  Rat   180 KQFRGLQSRIEQEQKFTVIRNGQLLQVPVAALVVGDIAQVKYGDLLPADGVLIQGNDLKIDESSL 244

  Fly   274 TGETEPARKITD---VLLNNTNVKDHSNMKNIAFMGTLVRCGNGKGIVVSTGERSEFGEVFKMMQ 335
            |||::..||..|   :||:.|:|.:                |:|:.:|.:.|..|:.|.:|.::.
  Rat   245 TGESDHVRKSADKDPMLLSGTHVME----------------GSGRMVVTAVGVNSQTGIIFTLLG 293

  Fly   336 A---EEAPK-----------------------------TPL-------------------QKSMD 349
            |   ||..|                             .||                   :|...
  Rat   294 AGGEEEEKKDKKGKQQDGAMDSSQTRAKKQDGAVAMEMQPLKSAEGGEMEEREKKKANVPKKEKS 358

  Fly   350 ILGAQLSFYSFLI---------IGVIMLL-------------GWL-QGKPL-----SEMFNISVS 386
            :|..:|:..:..|         |.||:|:             .|| :..|:     .:.|.|.|:
  Rat   359 VLQGKLTKLAVQIGKAGLVMSAITVIILVLYFVIETFVVDGRVWLAECTPVYVQYFVKFFIIGVT 423

  Fly   387 LAVAAIPEGLPIVVTVTLALGVMRMAKRNSIVKKLPTVETLGCVNVICSDKTGTLTKNEMTATII 451
            :.|.|:|||||:.||::||..|.:|.|.|::|:.|...||:|....||||||||||.|.||..
  Rat   424 VLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVV-- 486

  Fly   452 ITSDGYMADVTGAGYNDQGEIHIRHCNNVEMAKTNITNLLEIGAVCNNAYI-------QNGTL-- 507
               ..|:           |:.|.:...........|.:||......|:||.       :.|.|
  Rat   487 ---QSYL-----------GDTHYKEIPAPSALTPKILDLLVHAISINSAYTTKILPPEKEGALPR 537

  Fly   508 -LGQPTEGALVA--VAMKNGMYATAENYVRIQ---EYPFSSEQKMMAVKCIHKYNNNKEEIFFAK 566
             :|..||.||:.  :.:|.......|.....|   .|.|:|.:|.|:. .|...:....  .|:|
  Rat   538 QVGNKTECALLGFILDLKRDFQPVREQIPEDQLYKVYTFNSVRKSMST-VIRMPDGGFR--LFSK 599

  Fly   567 GALETLLPQCTKYQFGTQTV----PLTKQNEAEFLAEAYEIGRKGLRVLALA------------- 614
            ||.|.||.:||........:    |..:.:..:.:.|  .:...|||.:.:|
  Rat   600 GASEILLKKCTNILNSNGELRGFRPRDRDDMVKKIIE--PMACDGLRTICIAYRDFSAIQEPDWD 662

  Fly   615 -KGRSMQDLIYCGLVGITDPPRPLVRESIEMLMQSGVRVKMVTGDAQETALAIDPSRRLQAVPTH 678
             :...:.||....:|||.||.||.|.|:|....::|:.|:|||||...||.||
  Rat   663 NENEVVGDLTCIAVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAI------------ 715

  Fly   679 AIPAWPTAGGVPLCSASACCSTNCLENAMKEIYLTALAQQGLPLVTANLIGIDTIHHQTLSGQEM 743
                           |:.|                .:.|.|...:             .|.|:|.
  Rat   716 ---------------AAKC----------------GIIQPGEDFL-------------CLEGKEF 736

  Fly   744 D--------QMNEHQLDKVANNVSVFYRVSPRHKLEIVKSL-------QRSGNIVGMTGDGVNDG 793
            :        ::.:.:||||...:.|..|.||..|..:||.:       ||  .:|.:||||.|||
  Rat   737 NRRIRNEKGEIEQERLDKVWPKLRVLARSSPTDKHTLVKGIIDSTTGEQR--QVVAVTGDGTNDG 799

  Fly   794 VALKKADIGIAMGKNGTDVCKEAADMILVNDDFHTIIAAIEEGKGIFYNIRNFVRFQLSTSIAAL 858
            .||||||:|.|||..||||.|||:|:||.:|:|.:|:.|:..|:.::.:|..|::|||:.::.|:
  Rat   800 PALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAV 864

  Fly   859 --------------------------------------------------------ALIALATLM 867
                                                                    .|:.||.:.
  Rat   865 IVAFTGACITQNILMIPRGNLTPISSHFPLPHQPWNAHLLSVCELLSSFYFIDSIYGLVHLAPVT 929

  Fly   868 DI-------------------------ANPLNAMQILWINIIMDGPPAQSLGVEPVDHDVLKQKP 907
            .|                         .:||.|:|:||:|:|||...:.:|..||....:|.:||
  Rat   930 LIFKETLIGDDKKAGWGQHFCLFLPCEDSPLKAVQMLWVNLIMDTFASLALATEPPTESLLLRKP 994

  Fly   908 RNVKQPMITKSVVVNVLLSA--SIIVLGTLWVFQREMADGTLGKT-------KRDTTMTFTCFVF 963
            ....:|:|:::::.|:|..|  .:.::.||........|...|:.       ....|:.|..||.
  Rat   995 YGRDKPLISRTMMKNILGHAVYQLTIIFTLLFVGELFFDIDSGRNAPLHSPPSEHYTIIFNTFVM 1059

  Fly   964 FDMFNALSCRS--QTKSVFTIGLTTNRMFLLAVAFSIIGQMLVVYF 1007
            ..:||.::.|.  ..::||. |:.:|.:|...|..:...|:::|.|
  Rat  1060 MQLFNEINARKIHGERNVFD-GIFSNPIFCTIVLGTFGIQIVIVQF 1104

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SPoCk	NP_001262220.1	P-type_ATPase_SPCA	139..1042	CDD:319779	277/1122 (25%)
Atp2b3	XP_038955468.1	ATPase-IIB_Ca	19..1142	CDD:273668	289/1211 (24%)
		ATP_Ca_trans_C	1181..1256	CDD:463575