DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SPoCk and Atp2b1

DIOPT Version :9

Sequence 1:	NP_001262220.1	Gene:	SPoCk / 40495	FlyBaseID:	FBgn0052451	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	XP_038934528.1	Gene:	Atp2b1 / 29598	RGDID:	621303	Length:	1258	Species:	Rattus norvegicus

Alignment Length:	1098	Identity:	282/1098 - (25%)
Similarity:	466/1098 - (42%)	Gaps:	286/1098 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 GLTLTPEMLLSTSESS------THSASEVAG---RLQVDVRTGLKWTEA--KYRAKIIGHNELLL 150
            |:||.....|....|:      ..|..:|.|   :|:.....||....|  :.|..:.|.|  .:
  Rat    28 GITLAELRALMELRSTDALRKIQESYGDVYGICTKLKTSPNEGLSGNPADLERREAVFGKN--FI 90

  Fly   151 VAEDP------TWKKYIEQFRNPLILLLLGSALVSVIMKQF-----DDAV--------------- 189
            ..:.|      .|    |..::..:::|..:|:||:.:..:     |:|:
  Rat    91 PPKKPKTFLQLVW----EALQDVTLIILEIAAIVSLGLSFYQPPEGDNALCGEVSVGEEEGEGET 151

  Fly   190 ------SITIAILIVVTVAFIQEYRSEKSLEELKKLVPPE--CHCLREGRLDTFLARELVPGDIV 246
                  :|.::::.||.|....::..||....|:..:..|  ...:|.|::......::..|||.
  Rat   152 GWIEGAAILLSVVCVVLVTAFNDWSKEKQFRGLQSRIEQEQKFTVIRGGQVIQIPVADITVGDIA 216

  Fly   247 HLNVGDRVPADVRLFEAVDLSIDESSFTGETEPARKITD---VLLNNTNVKDHSNMKNIAFMGTL 308
            .:..||.:|||..|.:..||.|||||.|||::..:|..|   :||:.|:|.:
  Rat   217 QVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKKSLDKDPLLLSGTHVME------------- 268

  Fly   309 VRCGNGKGIVVSTGERSEFGEVFKM---------------------------------------- 333
               |:|:.:|.:.|..|:.|.:|.:
  Rat   269 ---GSGRMVVTAVGVNSQTGIIFTLLGAGGEEEEKKDEKKKEKKNKKQDGAIENRNKAKAQDGAA 330

  Fly   334 -----MQAEEA----------------PKTPLQKSMDILGAQLSFYSFLI--IGVIMLL------ 369
                 :::||.                .|:.||..:..|..|:.....|:  |.||:|:
  Rat   331 MEMQPLKSEEGGDGDEKDKKKANLPKKEKSVLQGKLTKLAVQIGKAGLLMSAITVIILVLYFVID 395

  Fly   370 -GWLQGKP-LSE-----------MFNISVSLAVAAIPEGLPIVVTVTLALGVMRMAKRNSIVKKL 421
             .|:|.:| |:|           .|.|.|::.|.|:|||||:.||::||..|.:|.|.|::|:.|
  Rat   396 TFWVQKRPWLAECTPIYIQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHL 460

  Fly   422 PTVETLGCVNVICSDKTGTLTKNEMTATIIITSDGYMADVTGAGYNDQGEIHIRHCNNVEMAKTN 486
            ...||:|....||||||||||.|.||             |..|..|::   |.:.....|....|
  Rat   461 DACETMGNATAICSDKTGTLTMNRMT-------------VVQAYINEK---HYKKVPEPEAIPPN 509

  Fly   487 ITNLLEIGAVCNNAYI-------QNGTL---LGQPTEGALVA--VAMKNGMYATAENYV----RI 535
            |.:.|..|...|.||.       :.|.|   :|..||.||:.  :.:|.. |....|.:    ..
  Rat   510 ILSYLVTGISVNCAYTSKILPPEKEGGLPRHVGNKTECALLGFLLDLKRD-YQDVRNEIPEEALY 573

  Fly   536 QEYPFSSEQKMMAVKCIHKYNNNKEEIFFAKGALETLLPQCTKYQFGTQTVPLTKQNEAEFLAEA 600
            :.|.|:|.:|.|:.  :.|.::....| |:|||.|.:|.:|.|.........:.:..:.:.:.:.
  Rat   574 KVYTFNSVRKSMST--VLKNSDGSFRI-FSKGASEIILKKCFKILSANGEAKVFRPRDRDDIVKT 635

  Fly   601 Y--EIGRKGLRVLALA---------------KGRSMQDLIYCGLVGITDPPRPLVRESIEMLMQS 648
            .  .:..:|||.:.||               :...:..|....:|||.||.||.|.|:|:...::
  Rat   636 VIEPMASEGLRTICLAFRDFPAGEPEPEWDNENDVVTGLTCIAVVGIEDPVRPEVPEAIKKCQRA 700

  Fly   649 GVRVKMVTGDAQETALAIDPSRRLQAVPTHAIPAWPTAGGVPLCSASACCSTN------CLENAM 707
            |:.|:|||||...||.||                           |:.|...:      |||.
  Rat   701 GITVRMVTGDNINTARAI---------------------------ATKCGILHPGEDFLCLEG-- 736

  Fly   708 KEIYLTALAQQGLPLVTANLIGIDTIHHQTLSGQEMDQMNEHQLDKVANNVSVFYRVSPRHKLEI 772
            |:.......::|                         ::.:.::||:...:.|..|.||..|..:
  Rat   737 KDFNRRIRNEKG-------------------------EIEQERIDKIWPKLRVLARSSPTDKHTL 776

  Fly   773 VKSL-------QRSGNIVGMTGDGVNDGVALKKADIGIAMGKNGTDVCKEAADMILVNDDFHTII 830
            ||.:       ||  .:|.:||||.|||.||||||:|.|||..||||.|||:|:||.:|:|.:|:
  Rat   777 VKGIIDSTVSEQR--QVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIV 839

  Fly   831 AAIEEGKGIFYNIRNFVRFQLSTSIAALALIALATLMDIANPLNAMQILWINIIMDGPPAQSLGV 895
            .|:..|:.::.:|..|::|||:.::.|:.:......:...:||.|:|:||:|:|||...:.:|..
  Rat   840 KAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTLASLALAT 904

  Fly   896 EPVDHDVLKQKPRNVKQPMITKSVVVNVLLSA--SIIVLGTLWVFQREMADGTLGKT-------K 951
            ||....:|.:||....:|:|:::::.|:|..|  .::|:.||.....:..|...|:.       .
  Rat   905 EPPTESLLLRKPYGRNKPLISRTMMKNILGHAFYQLVVVFTLLFAGEKFFDIDSGRNAPLHAPPS 969

  Fly   952 RDTTMTFTCFVFFDMFNALSCRS--QTKSVFTIGLTTNRMFLLAVAFSIIGQMLVVYF 1007
            ...|:.|..||...:||.::.|.  ..::||. |:..|.:|...|..:.:.|:::|.|
  Rat   970 EHYTIVFNTFVLMQLFNEINARKIHGERNVFE-GIFNNAIFCTIVLGTFVVQIIIVQF 1026

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPoCk	NP_001262220.1	ATPase-IIA2_Ca	110..1049	CDD:130585	278/1085 (26%)
		Cation_ATPase_N	112..179	CDD:279080	15/83 (18%)
		E1-E2_ATPase	191..425	CDD:278548	79/320 (25%)
		Cation_ATPase	496..579	CDD:289987	27/98 (28%)
		COG4087	<760..823	CDD:226572	37/69 (54%)
		Cation_ATPase_C	872..1044	CDD:279079	42/147 (29%)
Atp2b1	XP_038934528.1	ATPase-IIB_Ca	15..1064	CDD:273668	282/1098 (26%)
Atp2b1	XP_038934528.1	ATP_Ca_trans_C	1103..1187	CDD:403580
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334743
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.940