DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SPoCk and Atp1a4

DIOPT Version :9

Sequence 1:	NP_001262220.1	Gene:	SPoCk / 40495	FlyBaseID:	FBgn0052451	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	NP_001257959.1	Gene:	Atp1a4 / 29132	RGDID:	61952	Length:	1028	Species:	Rattus norvegicus

Alignment Length:	1144	Identity:	315/1144 - (27%)
Similarity:	493/1144 - (43%)	Gaps:	273/1144 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 DSKPNPQRTISHVKDSRAVPQNVKPGKVADMKDCKEPDEDNVDQQNGNIIQTGLTLTPEMLLSTS 109
            :.||.|  |:      ||...|.:|......||.:|..::.|...:      .|||
  Rat    12 EQKPRP--TL------RASNTNRQPKVKRRKKDLEELKKEVVMDDH------KLTL--------- 53

  Fly   110 ESSTHSASEVAGRLQVDVRTGLKWTEAKYRAKIIGHNELLLVAEDPTWKKYIEQ-FRNPLILLLL 173
                   .|::.:..||:..||..|:|:....:.|.|.|......|.|.|:.:| |....:||..
  Rat    54 -------DELSAKYSVDLTKGLSVTDAQEILTLNGPNVLTPPPTTPEWIKFCKQLFGGFSLLLWT 111

  Fly   174 GSAL--------VSVIMKQFDD---AVSITIAILIVVT--VAFIQEYRSEKSLEELKKLVPPECH 225
            ||.|        ||...:..:.   .:.|.::.::::|  .::.||.:|.|.:|..|.:||.:..
  Rat   112 GSLLCFLAYGIHVSYYQENANKDNLYLGIVLSAVVIITGCFSYYQEAKSSKIMESFKTMVPQQAL 176

  Fly   226 CLREGRLDTFLARELVPGDIVHLNVGDRVPADVRLFEAVDLSIDESSFTGETEPARKITDVLLNN 290
            .:|:|.......|::|.||:|.:..||:||||:|:..|....:|.||.|||:||..:..|.
  Rat   177 VIRDGEKMQINVRDVVLGDLVEVKGGDQVPADIRVIAAQGCKVDNSSLTGESEPQSRCPDC---- 237

  Fly   291 TNVKDHSN---MKNIAFMGTLVRCGNGKGIVVSTGERSEFGEVFKMMQAEEAPKTPLQKSMD--- 349
                .|.|   .:||.|..|....|..:|:|::||:.:..|.:..:.......|||:...::
  Rat   238 ----THENPLETRNIIFFSTNCVEGTARGVVIATGDHTVMGRIASLTSGLTMGKTPIATEIEHFI 298

  Fly   350 --------ILGAQLSFYSFLIIG------VIMLLGWLQGKPLSEMFNISVSLAVAAIPEGLPIVV 400
                    .||....|.| ||:|      ||.|:|                :.||.:||||...|
  Rat   299 HIITAVAVFLGVTFFFLS-LILGYTWLDAVIFLIG----------------IIVANVPEGLLATV 346

  Fly   401 TVTLALGVMRMAKRNSIVKKLPTVETLGCVNVICSDKTGTLTKNEMT-ATIIITSDGYMAD---- 460
            ||.|.|...|||::|.:||.|..|||||..:.||||||||||:|.|| |.:......|.||
  Rat   347 TVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHLWFDKTVYEADTSEE 411

  Fly   461 -VTGAGYNDQGEIHIRHCNNVEMAKTNIT--NLLEIGAVCNNA---------YIQNGTLLGQPTE 513
             .||..:                .|::.|  .|..|..:||.|         .|...|..|..:|
  Rat   412 QTTGKTF----------------PKSSDTWFYLARIAGLCNRADFKPHQESLPITKRTTTGDASE 460

  Fly   514 GALVAVAMKNGMYATA----ENYVRIQEYPFSSEQKMMAVKCIHKYNNNKE-EIFFAKGALETLL 573
            .||:....::  |:..    :...::.|.||:|..|..  ..||...:|.| .:...|||.|.:|
  Rat   461 SALLKFIEQS--YSPVSEMRQKNPKVAEIPFNSTNKYQ--MSIHLLEDNSEAHVLLMKGAPERIL 521

  Fly   574 PQCTKYQFGTQTVPLTKQNEAEFLAEAYEIGRKGLRVLA---------LAKGRS---------MQ 620
            ..|:.:....|..|:.::.:.:|.....|:|..|.|||.         .:||..         |:
  Rat   522 DFCSSFLLNGQEYPMDEEMKTDFQNAYIELGGLGERVLGFCFLNLPSNFSKGFQFNTEELNFPME 586

  Fly   621 DLIYCGLVGITDPPRPLVRESIEMLMQSGVRVKMVTGDAQETALAIDPSRRLQAVPTHAIPAWPT 685
            :|.:.||:.:.||||..|.:::.....:|::|.|||||...||.||
  Rat   587 NLCFAGLISMIDPPRTAVPDAVSKCRSAGIKVIMVTGDHPITAKAI------------------- 632

  Fly   686 AGGVPLCSASACCSTNCLENAMKEIYLTALAQQGLPLVTANL-IGIDTIHHQTLS-----GQEMD 744
                                 .|.:.:.:.|.:....:.|.| |.|..:.::::.     |.|:.
  Rat   633 ---------------------AKSVGIISEANETAEDIAARLNISISQVSNKSIKAIVVHGSELK 676

  Fly   745 QMNEHQLDKVANNVS--VFYRVSPRHKLEIVKSLQRSGNIVGMTGDGVNDGVALKKADIGIAMGK 807
            .|:..|||.:..:..  ||.|.||:.||.||:..||.|.||.:|||||||..||||||||||||.
  Rat   677 DMDSGQLDNILKSYKEIVFARTSPQQKLIIVEGCQRLGAIVAVTGDGVNDSPALKKADIGIAMGI 741

  Fly   808 NGTDVCKEAADMILVNDDFHTIIAAIEEGKGIFYNIRNFVRFQLSTSIAALALIALATLMDIANP 872
            .|:||.|:||||||::|:|.:|:..:|||:.||.|::..:.:.|:::|..:....|..::.|..|
  Rat   742 TGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLLFIVLSIPLP 806

  Fly   873 LNAMQILWINIIMDGPPAQSLGVEPVDHDVLKQKPRNVKQPMITKSVVVNVLLSAS--------- 928
            |..:.||.|::..|..||.||..|..:.|::|:.|||.|    |.::|.:.|:..:
  Rat   807 LGTITILCIDLGTDMVPAISLAYETPESDIMKRLPRNPK----TDNLVNDRLIGMAYGQIGMIQA 867

  Fly   929 -------IIVL-----------------------------GTLWVF-QREMADGTLGKTKRDTTM 956
                   .::|                             |..|.: ||::.:.|.      .|.
  Rat   868 LAGFFTYFVILAENGFKPLDLLGIRLYWDDTNLNDLEDTYGQQWTYEQRKVVEFTC------QTA 926

  Fly   957 TFTCFVFFDMFNALSCRSQTKSVFTIGLTTNRMFLLAVAFSIIGQMLVVYFPPLQMVFQTEALTP 1021
            .|...|.....:.:.|:::..|:|..|: .|::.:..:....|....:.|.|.:.:     ||..
  Rat   927 FFISIVIVQWADLIICKTRRNSLFKQGM-KNKVLIFGLLEETILAACLSYIPGMDV-----ALRM 985

  Fly  1022 YDI---FFLVSLTSSVL--VVSEIKK---------WFER 1046
            |.:   ::..:|..|||  :..|::|         |.|:
  Rat   986 YPLKINWWFCALPYSVLIFIYDEVRKLIIRRRPGGWLEK 1024

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPoCk	NP_001262220.1	ATPase-IIA2_Ca	110..1049	CDD:130585	300/1079 (28%)
		Cation_ATPase_N	112..179	CDD:279080	20/75 (27%)
		E1-E2_ATPase	191..425	CDD:278548	78/255 (31%)
		Cation_ATPase	496..579	CDD:289987	25/96 (26%)
		COG4087	<760..823	CDD:226572	43/62 (69%)
		Cation_ATPase_C	872..1044	CDD:279079	46/231 (20%)
Atp1a4	NP_001257959.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..36		8/31 (26%)
		ATPase-IIC_X-K	32..1028	CDD:273445	307/1116 (28%)
		Cation_ATPase_N	46..119	CDD:214842	23/94 (24%)
		Interaction with phosphoinositide-3 kinase. /evidence=ECO:0000250	87..89		0/1 (0%)
		E1-E2_ATPase	140..371	CDD:278548	78/255 (31%)
		Cation_ATPase	434..526	CDD:289987	25/95 (26%)
		COG4087	608..757	CDD:226572	66/188 (35%)
		Cation_ATPase_C	804..1013	CDD:279079	46/224 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334752
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.850