DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SPoCk and Atp1a4

DIOPT Version :9

Sequence 1:	NP_001262220.1	Gene:	SPoCk / 40495	FlyBaseID:	FBgn0052451	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	NP_038762.1	Gene:	Atp1a4 / 27222	MGIID:	1351335	Length:	1032	Species:	Mus musculus

Alignment Length:	1156	Identity:	313/1156 - (27%)
Similarity:	491/1156 - (42%)	Gaps:	258/1156 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 PGSTVLIESPTTSSGVRNRRSKIKGVDSKPNPQRTISHVKDSRAVPQNVKPGKVADMKDCKEPDE 83
            ||....:|:|    |..|:         ||.|        .:|:...|.:|......||.:|..:
Mouse     3 PGKEKEVEAP----GELNQ---------KPRP--------STRSSTTNRQPKMKRRKKDLEELKK 46

  Fly    84 DNVDQQNGNIIQTGLTLTPEMLLSTSESSTHSASEVAGRLQVDVRTGLKWTEAKYRAKIIGHNEL 148
            :.|...:      .|||                .|::.:..||:..||...||:......|.|.|
Mouse    47 EVVMDDH------KLTL----------------DELSAKYSVDLTKGLSILEAQDILFQNGPNVL 89

  Fly   149 LLVAEDPTWKKYIEQ-FRNPLILLLLGSAL----VSVIMKQFDD-------AVSITIAILIVVT- 200
            ......|.|.|:..| |....:||..|:.|    ..:.:..:.:       .:.|.::.::::|
Mouse    90 TPPPTTPEWVKFCRQLFGGFSLLLWTGACLCFLAYGIHVNYYKENANKDNLYLGIVLSAVVIITG 154

  Fly   201 -VAFIQEYRSEKSLEELKKLVPPECHCLREGRLDTFLARELVPGDIVHLNVGDRVPADVRLFEAV 264
             .::.||.:|.|.:|..|.:||.:...:|:|.......|::|.||:|.:..||::|||:|:..|.
Mouse   155 CFSYYQEAKSSKIMESFKNMVPQQALVIRDGEKMQINVRDVVLGDLVEVKGGDQIPADIRVISAQ 219

  Fly   265 DLSIDESSFTGETEPARKITDVLLNNTNVKDHSN---MKNIAFMGTLVRCGNGKGIVVSTGERSE 326
            ...:|.||.|||:||..:..|.        .|.|   .:||.|..|....|..:|||::||:.:.
Mouse   220 GCKVDNSSLTGESEPQSRCPDC--------THENPLETRNIIFFSTNCVEGTARGIVIATGDYTV 276

  Fly   327 FGEVFKMMQAEEAPKTPLQKSMDILGAQLSFYSFLIIGVIMLLG----WLQ---GKPLSEMFNIS 384
            .|.:..:....:..|||       :..::..:..||..|.:.||    ||.   |....:.....
Mouse   277 MGRIASLTSGLQMGKTP-------IATEIEHFIHLITAVAVFLGVSFFWLSIILGYTWLDAVIFL 334

  Fly   385 VSLAVAAIPEGLPIVVTVTLALGVMRMAKRNSIVKKLPTVETLGCVNVICSDKTGTLTKNEMT-A 448
            :.:.||.:||||...|||.|.|...|||::|.:||.|..|||||..:.||||||||||:|.|| |
Mouse   335 IGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVA 399

  Fly   449 TIIITSDGYMAD-----VTGAGYNDQGEIHIRHCNNVEMAKTNIT--NLLEIGAVCNNA------ 500
            .:......|.||     .||..:                .|::.|  .|..|..:||.|
Mouse   400 HLWFDKTVYEADTSEEQTTGKTF----------------PKSSDTWFYLARIAGLCNRADFKPHQ 448

  Fly   501 ---YIQNGTLLGQPTEGALVAVAMK--NGMYATAENYVRIQEYPFSSEQKMMAVKCIHKYNNNKE 560
               .|......|..:|.||:....:  |.:....:...::.|.||:|..|..  ..||...:|.|
Mouse   449 ESVPIAKRATTGDASESALLKFIEQSYNPVSEMRQKNPKVAEIPFNSTNKYQ--MSIHLLEDNSE 511

  Fly   561 -EIFFAKGALETLLPQCTKYQFGTQTVPLTKQNEAEFLAEAYEIGRKGLRVLA---------LAK 615
             .:...|||.|.:...|:.:....|..|:.::.:.:|.....|:|..|.|||.         .:|
Mouse   512 AHVLLMKGAPERIFDFCSSFLLNGQEYPMDEEMKMDFQNAYIELGGLGERVLGFCFLNLPSNFSK 576

  Fly   616 GRS---------MQDLIYCGLVGITDPPRPLVRESIEMLMQSGVRVKMVTGDAQETALAIDPSRR 671
            |..         |::|.:.||:.:.||||..|.:::.....:|::|.|||||
Mouse   577 GFQFNTDELNFPMENLCFAGLISMIDPPRTAVPDAVSKCRSAGIKVIMVTGD------------- 628

  Fly   672 LQAVPTHAIPAWPTAGGVPLCSASACCSTNCLENAMKEIYLTALAQQGLPLVTANLIGIDTIHHQ 736
                  |.|.|...|..|.:.|..        .:..::|    .|:..:|:...|...:..|
Mouse   629 ------HPITAKAIAKSVGIISEG--------NDTAEDI----AARLNIPISQVNNKSVKAI--- 672

  Fly   737 TLSGQEMDQMNEHQLDKVANNVS--VFYRVSPRHKLEIVKSLQRSGNIVGMTGDGVNDGVALKKA 799
            .:.|.|:..|...|||.:..:..  ||.|.||:.||.||:..||.|.||.:|||||||..|||||
Mouse   673 VVHGSELKDMESQQLDDILKSYKEIVFARTSPQQKLIIVEGCQRLGAIVAVTGDGVNDSPALKKA 737

  Fly   800 DIGIAMGKNGTDVCKEAADMILVNDDFHTIIAAIEEGKGIFYNIRNFVRFQLSTSIAALALIALA 864
            |||||||..|:||.|:||||||::|:|.:|:..:|||:.||.|::..:.:.|:::|..:....|.
Mouse   738 DIGIAMGITGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLLF 802

  Fly   865 TLMDIANPLNAMQILWINIIMDGPPAQSLGVEPVDHDVLKQKPRNVKQPMITKSVVVNVLLSAS- 928
            .::.|..||..:.||.|::..|..||.||..|..:.|::|:.|||.|    |.::|.|.|:..:
Mouse   803 IILSIPLPLGTITILCIDLGTDMVPAISLAYESPESDIMKRLPRNPK----TDNLVNNRLIGMAY 863

  Fly   929 ---------------IIVL-----------------------------GTLWVF-QREMADGTLG 948
                           .::|                             |..|.: ||::.:.|.
Mouse   864 GQIGMIQALAGFFTYFVILAENGFKPLDLLGIRLYWDDTQLNDLEDSYGQQWTYEQRKVVEFTC- 927

  Fly   949 KTKRDTTMTFTCFVFFDMFNALSCRSQTKSVFTIGLTTNRMFLLAVAFSIIGQMLVVYFP----- 1008
                 .|..|...|.....:.:.|:::..|:|..|: .|::.:..:....:....:.|.|
Mouse   928 -----QTAFFISIVIVQWADLIICKTRRNSLFKQGM-KNKILIFGLLEETVLAAFLSYVPGMDVS 986

  Fly  1009 ----PLQMVFQTEALTPYDIFFLVSLTSSVLVVSEIKK---------WFER 1046
                ||::.:...|| ||.:.        :.|..||:|         |.|:
Mouse   987 LRMYPLKINWWFCAL-PYSVL--------IFVYDEIRKLIIRRRPGGWLEK 1028

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPoCk	NP_001262220.1	ATPase-IIA2_Ca	110..1049	CDD:130585	294/1065 (28%)
		Cation_ATPase_N	112..179	CDD:279080	19/71 (27%)
		E1-E2_ATPase	191..425	CDD:278548	75/245 (31%)
		Cation_ATPase	496..579	CDD:289987	23/94 (24%)
		COG4087	<760..823	CDD:226572	43/62 (69%)
		Cation_ATPase_C	872..1044	CDD:279079	47/235 (20%)
Atp1a4	NP_038762.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..42		14/59 (24%)
		ATPase-IIC_X-K	36..1032	CDD:273445	301/1102 (27%)
		Cation_ATPase_N	50..123	CDD:214842	22/94 (23%)
		Interaction with phosphoinositide-3 kinase. /evidence=ECO:0000250	91..93		0/1 (0%)
		E1-E2_ATPase	144..375	CDD:278548	75/245 (31%)
		Cation_ATPase	438..530	CDD:289987	23/93 (25%)
		COG4087	<696..761	CDD:226572	43/64 (67%)
		Cation_ATPase_C	808..1017	CDD:279079	47/228 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831037
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.850