DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SPoCk and Atp2a3

DIOPT Version :9

Sequence 1:	NP_001262220.1	Gene:	SPoCk / 40495	FlyBaseID:	FBgn0052451	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	XP_038941199.1	Gene:	Atp2a3 / 25391	RGDID:	2175	Length:	1069	Species:	Rattus norvegicus

Alignment Length:	1053	Identity:	327/1053 - (31%)
Similarity:	521/1053 - (49%)	Gaps:	182/1053 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 ESSTHSASEVAGRLQVDVRTGL---KWTEAKYRAKIIGHNELLLVAEDPTWKKYIEQFRNPLILL 171
            |:...||::|..|..|....||   :.|:|:.|   .|.|||........|:..:|||.:.|:.:
  Rat     3 EAHLLSAADVLRRFSVTAEGGLTLEQVTDARER---YGPNELPTEEGKSLWELVVEQFEDLLVRI 64

  Fly   172 LLGSALVSVIMKQFDDAVSITIA-------ILIVVTVAFI---QEYRSEKSLEELKKLVPPECHC 226
            ||.:||||.::..|::....|.|       :||:|..|.:   ||..:|.::|.||:..|.....
  Rat    65 LLLAALVSFVLAWFEEGEETTTAFVEPLVIMLILVANAIVGVWQERNAESAIEALKEYEPEMGKV 129

  Fly   227 LREGR--LDTFLARELVPGDIVHLNVGDRVPADVRLFE--AVDLSIDESSFTGETEPARKITDVL 287
            :|..|  :....||::||||||.:.|||:||||:||.|  :..|.:|:|..|||:....|.||.:
  Rat   130 IRSDRKGVQRIRARDIVPGDIVEVAVGDKVPADLRLIEIKSTTLRVDQSILTGESVSVTKHTDAI 194

  Fly   288 LNNTNVKDHSNMKNIAFMGTLVRCGNGKGIVVSTGERSEFGEVFKMMQAEEAPKTPLQKSMDILG 352
            .:...|  :.:.||:.|.||.:..|...|:.|:||..:|.|::...|.|.|..:||||:.:|..|
  Rat   195 PDPRAV--NQDKKNMLFSGTNIASGKALGVAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEFG 257

  Fly   353 AQLSFYSFLIIGVIMLL------------GWLQGKPLSEMFNISVSLAVAAIPEGLPIVVTVTLA 405
            .|||....:|...:.::            .||:|...  .|.|:|:|||||||||||.|:|..||
  Rat   258 RQLSHAISVICVAVWVINIGHFADPAHGGSWLRGAVY--YFKIAVALAVAAIPEGLPAVITTCLA 320

  Fly   406 LGVMRMAKRNSIVKKLPTVETLGCVNVICSDKTGTLTKNEMTAT---IIITSDG-----YMADVT 462
            ||..|||::|:||:.||:||||||.:|||||||||||.|:|:..   ::..::.     :...::
  Rat   321 LGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVVAEAEAGACRLHEFTIS 385

  Fly   463 GAGYNDQGEI----HIRHCNNVEMAKTNITNLLEIGAVCNNAYIQNGTL------LGQPTEGALV 517
            |..|..:||:    .:..|...:    .:..|..|.|:||::.:.....      :|:.||.||.
  Rat   386 GTTYTPEGEVRQGEQLVRCGQFD----GLVELATICALCNDSALDYNEAKGVYEKVGEATETALT 446

  Fly   518 AVAMKNGMYAT-AENYVRIQE-----------------YPFSSEQKMMAVKCIHKYNNNKEE--I 562
            .:..|..::.| .:...|::.                 ..||.::|.|:|.|.....:.|.:  .
  Rat   447 CLVEKMNVFDTDLKGLSRVERAGACNSVIKQLMRKEFTLEFSRDRKSMSVYCTPTRADPKAQGSK 511

  Fly   563 FFAKGALETLLPQCTKYQFGTQTVPLTKQNEAEFLAEA--YEIGRKGLRVLALA------KGRSM 619
            .|.|||.|:::.:|:..:.|::||||:..:....||:.  :..|...||.||||      :...|
  Rat   512 MFVKGAPESVIERCSSVRVGSRTVPLSATSREHILAKIRDWGSGSDTLRCLALATRDTPPRKEDM 576

  Fly   620 Q------------DLIYCGLVGITDPPRPLVRESIEMLMQSGVRVKMVTGDAQETALAIDPSRRL 672
            |            .|.:.|.||:.|||||.|...|....::|:||.|:|||.:.||:||  .|||
  Rat   577 QLDDCSQFVQYETGLTFVGCVGMLDPPRPEVAACITRCSRAGIRVVMITGDNKGTAVAI--CRRL 639

  Fly   673 QAVPTHAIPAWPTAGGVPLCSASACCSTNCLENAMKEIYLTALAQQGLPLVTANLIGIDTIHHQT 737
                                                          |:...|.:::|      :.
  Rat   640 ----------------------------------------------GIFGDTEDVLG------KA 652

  Fly   738 LSGQEMDQMNEHQLDKVANNVSVFYRVSPRHKLEIVKSLQRSGNIVGMTGDGVNDGVALKKADIG 802
            .:|:|.|.::..|..:.......|.||.|.||..||::||....|..||||||||..|||||:||
  Rat   653 YTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIG 717

  Fly   803 IAMGKNGTDVCKEAADMILVNDDFHTIIAAIEEGKGIFYNIRNFVRFQLSTSIAALALIALATLM 867
            |||| :||.|.|.||:|:|.:|:|.:|:||:|||:.|:.|::.|:|:.:|:::..:..|.|..::
  Rat   718 IAMG-SGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAIL 781

  Fly   868 DIANPLNAMQILWINIIMDGPPAQSLGVEPVDHDVLKQKPRNVKQPMIT-----KSVVVNVLLSA 927
            .:...|..:|:||:|::.||.||.:||..|.|.|::::.|||.::.:|:     :.:.:.|.:..
  Rat   782 GLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMEKLPRNPREALISGWLFFRYLAIGVYVGL 846

  Fly   928 SIIVLGTLWV----------------FQREMADGTL--------GKTKRDTTMTFTCFVFFDMFN 968
            :.:...|.|.                |.:...|..|        .:::..|||..:..|..:|.|
  Rat   847 ATVAAATWWFLYDAEGPQVTFHQLRNFLKCSEDNPLFAGIDCEVFESRFPTTMALSVLVTIEMCN 911

  Fly   969 ALSCRSQTKSVFTIGLTTNRMFLLAVAFSIIGQMLVVYFPPLQMVFQTEALTPYDIFFLVSLTSS 1033
            ||:..|:.:|:..:....|...|.||..|:....|::..|||.::||...|:......::.::..
  Rat   912 ALNSVSENQSLLRMPPWLNPWLLGAVVMSMALHFLILLVPPLPLIFQVTPLSGRQWGVVLQMSLP 976

  Fly  1034 VLVVSEIKKWFER 1046
            |:::.|..|:..|
  Rat   977 VILLDEALKYLSR 989

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPoCk	NP_001262220.1	ATPase-IIA2_Ca	110..1049	CDD:130585	327/1053 (31%)
		Cation_ATPase_N	112..179	CDD:279080	23/69 (33%)
		E1-E2_ATPase	191..425	CDD:278548	99/259 (38%)
		Cation_ATPase	496..579	CDD:289987	23/108 (21%)
		COG4087	<760..823	CDD:226572	38/62 (61%)
		Cation_ATPase_C	872..1044	CDD:279079	49/200 (25%)
Atp2a3	XP_038941199.1	P-type_ATPase_SERCA	5..989	CDD:319778	325/1049 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	1	1.010	-	-		D100699at2759
OrthoFinder	1	1.000	-	-		FOG0000231
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100158
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.830