DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SPoCk and Atp7a

DIOPT Version :9

Sequence 1:	NP_001262220.1	Gene:	SPoCk / 40495	FlyBaseID:	FBgn0052451	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	NP_434690.1	Gene:	Atp7a / 24941	RGDID:	2179	Length:	1492	Species:	Rattus norvegicus

Alignment Length:	823	Identity:	171/823 - (20%)
Similarity:	297/823 - (36%)	Gaps:	294/823 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 WKKYIEQFR-------NPLILLLLGS------ALVSVIMKQFDDAVSITIAI-----LIVVTVA- 202
            |..||:.::       |..:|::|.:      :||.:::..::.|....|..     ::.|.:|
  Rat   721 WYFYIQAYKALRHKTANMDVLIVLATTIAFAYSLVILLVAMYERAKVNPITFFDTPPMLFVFIAL 785

  Fly   203 --FIQEYRSEKSLEELKKLVP------------PECHCLREGRLDTFLARELVPGDIVHLNVGDR 253
              :::.....|:.|.|.||:.            .|...|.|.::|..|.:.   |||:.:..|.:
  Rat   786 GRWLEHIAKGKTSEALAKLISLQATEATIVTLNSENLLLSEEQVDVELVQR---GDIIKVVPGGK 847

  Fly   254 VPADVRLFEAVDLSIDESSFTGETEPARKITDVLLNNTNVKDHSNMKNIAFMGTLVRCG----NG 314
            .|.|.|:.|...: :|||..|||..|..|..                     |:.|..|    ||
  Rat   848 FPVDGRVIEGHSM-VDESLITGEAMPVAKKP---------------------GSTVIAGSINQNG 890

  Fly   315 KGIVVST--GERSEFGEVFKMMQAEEAPKTPLQKSMDILGAQLSFYSFLI-IGVIMLLGWL---- 372
            ..::.:|  |..:...::.|:::..:..|.|:|:..|.|...  |..|:: :.::.||.|:
  Rat   891 SLLIRATHVGADTTLSQIVKLVEEAQTSKAPIQQFADKLSGY--FVPFIVLVSIVTLLVWIIIGF 953

  Fly   373 ------------QGKPLSE-------MFNISVSLAVAAIPEGLPIVVTVTLALGVMRMAKRNSIV 418
                        ..:.:|.       .|..|:::...|.|..|.:.....:.:|....|:...::
  Rat   954 QNFEIVEAYFPGYNRSISRTETIIRFAFQASITVLCIACPCSLGLATPTAVMVGTGVGAQNGILI 1018

  Fly   419 KKLPTVETLGCVNVICSDKTGTLT-------------------KNEMTATIIITSD--------- 455
            |....:|....|.|:..|||||:|                   :|::.| |:.|::
  Rat  1019 KGGEPLEMAHKVKVVVFDKTGTITHGTPVVNQVKVLVESNKISRNKILA-IVGTAESNSEHPLGA 1082

  Fly   456 ---------------GYMAD---VTGAGY-----NDQGEIHIRHCNNVEMAKTNITN--LLEIGA 495
                           |...|   |.|.|.     |.:|   :.|.:|:::.:.||.|  |::|.|
  Rat  1083 AVTKYCKQELDTETLGTCTDFQVVPGCGISCKVTNIEG---LLHKSNLKIEENNIKNASLVQIDA 1144

  Fly   496 VCNNAYIQNGTLLGQPTEGALVAVAMKNGMYATAENYVRIQEYPFSSEQKMMAVKCIHKYNNNKE 560
            :...:         .|:...::...:.|.        |..|:|      |::.        .|:|
  Rat  1145 INEQS---------SPSSSMIIDAHLSNA--------VNTQQY------KVLI--------GNRE 1178

  Fly   561 EIFFAKGALETLLPQCTKYQFGTQTVPLTKQNEAEFLAEAYEIGRKGLRVLALAKGRSMQDLIYC 625
              :..:..|                  :...:..|.:.|....||..:.|       ::.|.: |
  Rat  1179 --WMIRNGL------------------VISNDVDESMIEHERRGRTAVLV-------TIDDEL-C 1215

  Fly   626 GLVGITDPPRPLVRESIEMLMQSGVRVKMVTGDAQETALAIDPSRRLQAVPTHAIPAWPTAGGVP 690
            ||:.|.|..:|....::.:|...|:.|.::|||..:||.:|
  Rat  1216 GLIAIADTVKPEAELAVHILKSMGLEVVLMTGDNSKTARSI------------------------ 1256

  Fly   691 LCSASACCSTNCLENAMKEIYLTALAQQGLPLVTANLIGIDTIHHQTLSGQEMDQMNEHQLDKVA 755
                                              |:.:||
  Rat  1257 ----------------------------------ASQVGI------------------------- 1262

  Fly   756 NNVSVFYRVSPRHKLEIVKSLQRSGNIVGMTGDGVNDGVALKKADIGIAMGKNGTDVCKEAADMI 820
              ..||..|.|.||:..||.||..|..|.|.|||:||..||..|.:|||:| .||||..||||::
  Rat  1263 --TKVFAEVLPSHKVAKVKQLQEEGKRVAMVGDGINDSPALAMASVGIAIG-TGTDVAIEAADVV 1324

  Fly   821 LVNDDFHTIIAAIEEGKGIFYNIR-NFVRFQLSTSIAALALIA 862
            |:.:|...::|:|:..:.....|| ||| |.|..::..:.:.|
  Rat  1325 LIRNDLLDVVASIDLSRKTVKRIRINFV-FALIYNLIGIPIAA 1366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPoCk	NP_001262220.1	ATPase-IIA2_Ca	110..1049	CDD:130585	171/823 (21%)
		Cation_ATPase_N	112..179	CDD:279080	7/34 (21%)
		E1-E2_ATPase	191..425	CDD:278548	56/283 (20%)
		Cation_ATPase	496..579	CDD:289987	9/82 (11%)
		COG4087	<760..823	CDD:226572	34/62 (55%)
		Cation_ATPase_C	872..1044	CDD:279079
Atp7a	NP_434690.1	HMA	11..73	CDD:238219
		HMA	174..236	CDD:238219
		HMA	280..337	CDD:238219
		HMA	380..442	CDD:238219
		HMA	484..545	CDD:238219
		HMA	559..622	CDD:238219
		P-type_ATPase_Cu-like	646..1380	CDD:319783	171/823 (21%)
		Endocytosis signal. /evidence=ECO:0000250\|UniProtKB:Q64430	1459..1460
		PDZD11-binding. /evidence=ECO:0000250	1478..1492
		Endocytosis signal. /evidence=ECO:0000250\|UniProtKB:Q64430	1479..1480
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334768
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.930