DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SPoCk and Atp1a3

DIOPT Version :9

Sequence 1:	NP_001262220.1	Gene:	SPoCk / 40495	FlyBaseID:	FBgn0052451	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	XP_017444264.1	Gene:	Atp1a3 / 24213	RGDID:	2169	Length:	1026	Species:	Rattus norvegicus

Alignment Length:	1099	Identity:	307/1099 - (27%)
Similarity:	483/1099 - (43%)	Gaps:	204/1099 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 KDSRAVPQNVKPGKVADMKDCKEPDEDNVDQQNGNIIQTGLTLTPEMLLSTSESSTHSASEVAGR 122
            ||.::.|:..|..:..|:.|.|:.                :.:|...:         |..||..:
  Rat    18 KDDKSSPKKSKAKERRDLDDLKKE----------------VAMTEHKM---------SVEEVCRK 57

  Fly   123 LQVDVRTGLKWTEAKYRAKIIGHNELLLVAEDPTWKKYIEQ-FRNPLILLLLGSALVSV---IMK 183
            ...|...||..::|:......|.|.|......|.|.|:..| |....|||.:|:.|..:   |..
  Rat    58 YNTDCVQGLTHSKAQEILARDGPNALTPPPTTPEWVKFCRQLFGGFSILLWIGAILCFLAYGIQA 122

  Fly   184 QFDDAVS-------ITIAILIVVT--VAFIQEYRSEKSLEELKKLVPPECHCLREGRLDTFLARE 239
            ..:|..|       |.:|.::::|  .::.||.:|.|.:|..|.:||.:...:|||......|.|
  Rat   123 GTEDDPSGDNLYLGIVLAAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIREGEKMQVNAEE 187

  Fly   240 LVPGDIVHLNVGDRVPADVRLFEAVDLSIDESSFTGETEPARKITDVLLNNTNVKDHSN---MKN 301
            :|.||:|.:..|||||||:|:..|....:|.||.|||:||..:..|.        .|.|   .:|
  Rat   188 VVVGDLVEIKGGDRVPADLRIISAHGCKVDNSSLTGESEPQTRSPDC--------THDNPLETRN 244

  Fly   302 IAFMGTLVRCGNGKGIVVSTGERSEFGEVFKMMQAEEAPKTPLQKSMD-----ILGAQLSF-YSF 360
            |.|..|....|..:|:||:||:|:..|.:..:....|..|||:...::     |.|..:.. .||
  Rat   245 ITFFSTNCVEGTARGVVVATGDRTVMGRIATLASGLEVGKTPIAIEIEHFIQLITGVAVFLGVSF 309

  Fly   361 LIIGVIMLLGWLQGKPLSEMFNISVSLAVAAIPEGLPIVVTVTLALGVMRMAKRNSIVKKLPTVE 425
            .|:.:|:...||      |.....:.:.||.:||||...|||.|.|...|||::|.:||.|..||
  Rat   310 FILSLILGYTWL------EAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVE 368

  Fly   426 TLGCVNVICSDKTGTLTKNEMT-ATIIITSDGYMADVTGAGYNDQGEIHIRHCNNVEMAKTNITN 489
            |||..:.||||||||||:|.|| |.:...:..:.||.|    .||........::..:|.::|..
  Rat   369 TLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTT----EDQSGTSFDKSSHTWVALSHIAG 429

  Fly   490 LLEIGAVCNNAYIQNG---------TLLGQPTEGALV-AVAMKNG-MYATAENYVRIQEYPFSSE 543
            |      ||.|..:.|         .:.|..:|.||: .:.:.:| :....|...::.|.||:|.
  Rat   430 L------CNRAVFKGGQDNIPVLKRDVAGDASESALLKCIELSSGSVKLMRERNKKVAEIPFNST 488

  Fly   544 QKMMAVKCIHKYN--NNKEEIFFAKGALETLLPQCTKYQFGTQTVPLTKQNEAEFLAEAYEIGRK 606
            .|...  .||:..  |:...:...|||.|.:|.:|.......:..||.::.:..|.....|:|..
  Rat   489 NKYQL--SIHETEDPNDNRYLLVMKGAPERILDRCATILLQGKEQPLDEEMKEAFQNAYLELGGL 551

  Fly   607 GLRVLALA----------KGRSM---------QDLIYCGLVGITDPPRPLVRESIEMLMQSGVRV 652
            |.|||...          ||.:.         .:|.:.||:.:.||||..|.:::.....:|::|
  Rat   552 GERVLGFCHYYLPEEQFPKGFAFDCDDVNFTTDNLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKV 616

  Fly   653 KMVTGDAQETALAIDPSRRLQAVPTHAIPAWPTAGGVPLCSASACCSTNCLENAMKEIYLTALAQ 717
            .|||||                   |.|.|...|.||.:.|..        ...:::|    .|:
  Rat   617 IMVTGD-------------------HPITAKAIAKGVGIISEG--------NETVEDI----AAR 650

  Fly   718 QGLPLVTANLIGID--TIHHQTLSGQEMDQMNEHQLDKVANNVS--VFYRVSPRHKLEIVKSLQR 778
            ..:|:...|.....  .||     |.::......|:|::..|.:  ||.|.||:.||.||:..||
  Rat   651 LNIPVSQVNPRDAKACVIH-----GTDLKDFTSEQIDEILQNHTEIVFARTSPQQKLIIVEGCQR 710

  Fly   779 SGNIVGMTGDGVNDGVALKKADIGIAMGKNGTDVCKEAADMILVNDDFHTIIAAIEEGKGIFYNI 843
            .|.||.:|||||||..||||||||:|||..|:||.|:||||||::|:|.:|:..:|||:.||.|:
  Rat   711 QGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNL 775

  Fly   844 RNFVRFQLSTSIAALALIALATLMDIANPLNAMQILWINIIMDGPPAQSLGVEPVDHDVLKQKPR 908
            :..:.:.|:::|..:....|..:.:|..||..:.||.|::..|..||.||..|..:.|::|::||
  Rat   776 KKSIAYTLTSNIPEITPFLLFIMANIPLPLGTITILCIDLGTDMVPAISLAYEAAESDIMKRQPR 840

  Fly   909 NVKQPMITKSVVVN-------------------VLLSASIIVLGTL------------------- 935
            |.:...:....:::                   |:|:.:..:.|.|
  Rat   841 NPRTDKLVNERLISMAYGQIGMIQALGGFFSYFVILAENGFLPGNLVGIRLNWDDRTVNDLEDSY 905

  Fly   936 ---WVF-QREMADGTLGKTKRDTTMTFTCFVFFDMFNALSCRSQTKSVFTIGLTTNRMFLLAVAF 996
               |.: ||::.:.|.      .|..|...|.....:.:.|:::..|||..|: .|::.:..:..
  Rat   906 GQQWTYEQRKVVEFTC------HTAFFVSIVVVQWADLIICKTRRNSVFQQGM-KNKILIFGLFE 963

  Fly   997 SIIGQMLVVYFPPLQMVFQTEALTPYDIFFLVSLTSSVLVVSEIKK---------WFER 1046
            .......:.|.|.:.:..:...|.|...|.....:..:.|..||:|         |.|:
  Rat   964 ETALAAFLSYCPGMDVALRMYPLKPSWWFCAFPYSFLIFVYDEIRKLILRRNPGGWVEK 1022

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPoCk	NP_001262220.1	ATPase-IIA2_Ca	110..1049	CDD:130585	299/1047 (29%)
		Cation_ATPase_N	112..179	CDD:279080	20/67 (30%)
		E1-E2_ATPase	191..425	CDD:278548	83/244 (34%)
		Cation_ATPase	496..579	CDD:289987	24/95 (25%)
		COG4087	<760..823	CDD:226572	42/62 (68%)
		Cation_ATPase_C	872..1044	CDD:279079	42/222 (19%)
Atp1a3	XP_017444264.1	ATPase-IIC_X-K	31..1026	CDD:273445	303/1086 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920