DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SPoCk and Atp2c1

DIOPT Version :9

Sequence 1:	NP_001262220.1	Gene:	SPoCk / 40495	FlyBaseID:	FBgn0052451	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	NP_001240760.1	Gene:	Atp2c1 / 235574	MGIID:	1889008	Length:	952	Species:	Mus musculus

Alignment Length:	1004	Identity:	579/1004 - (57%)
Similarity:	720/1004 - (71%)	Gaps:	92/1004 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 QRTISHVKDSRAVPQNVKPGKVADMKDCKEPDEDNVDQQNGNIIQTGLTLTPEMLLSTSESSTHS 115
            ::.:|.::..||..|..:..|:           .||:.:         |:.|  :|::..:|..:
Mouse    22 RKYLSTLRSQRAEEQVARFQKI-----------PNVENE---------TMIP--VLTSKRASELA 64

  Fly   116 ASEVAGRLQVDVRTGLKWTEAKYRAKIIGHNELLLVAEDPTWKKYIEQFRNPLILLLLGSALVSV 180
            .|||||.||.|::.||..:|..:|....|.||..:..::|.|||||.||:||||:|||.||::|:
Mouse    65 VSEVAGLLQADLQNGLNKSEVSHRRAFHGWNEFDISEDEPLWKKYISQFKNPLIMLLLASAVISI 129

  Fly   181 IMKQFDDAVSITIAILIVVTVAFIQEYRSEKSLEELKKLVPPECHCLREGRLDTFLARELVPGDI 245
            :|:|||||||||:||:|||||||:||||||||||||.|||||||||:|||:|:..|||:|||||.
Mouse   130 LMRQFDDAVSITVAIVIVVTVAFVQEYRSEKSLEELSKLVPPECHCVREGKLEHTLARDLVPGDT 194

  Fly   246 VHLNVGDRVPADVRLFEAVDLSIDESSFTGETEPARKIT--DVLLNNTNVKDHSNMKNIAFMGTL 308
            |.|:||||||||:|||||||||:||||.||||.|..|:|  ....|.    |.::..||||||||
Mouse   195 VCLSVGDRVPADLRLFEAVDLSVDESSLTGETAPCSKVTAPQPAANG----DLASRSNIAFMGTL 255

  Fly   309 VRCGNGKGIVVSTGERSEFGEVFKMMQAEEAPKTPLQKSMDILGAQLSFYSFLIIGVIMLLGWLQ 373
            ||||..||||:.|||.|||||||||||||||||||||||||:||.|||||||.|||:|||:|||.
Mouse   256 VRCGKAKGIVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYSFGIIGIIMLVGWLL 320

  Fly   374 GKPLSEMFNISVSLAVAAIPEGLPIVVTVTLALGVMRMAKRNSIVKKLPTVETLGCVNVICSDKT 438
            ||.:.|||.|||||||||||||||||||||||||||||.|:.:||||||.||||||.||||||||
Mouse   321 GKDILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKT 385

  Fly   439 GTLTKNEMTATIIITSDGYMADVTGAGYNDQGEIHIRHCNNVEMAKTN--ITNLLEIGAVCNNAY 501
            |||||||||.|.|:||||..|:|||.|||..||:.:.  .:|.....|  ::.::|.|.|||:|.
Mouse   386 GTLTKNEMTVTHILTSDGLHAEVTGVGYNQFGEVIVD--GDVVHGFYNPAVSRIVEAGCVCNDAV 448

  Fly   502 IQNGTLLGQPTEGALVAVAMKNGMYATAENYVRIQEYPFSSEQKMMAVKCIHKYNNNKEEIFFAK 566
            |:|.||:|:||||||:|:|||.|:....::|:|..|||||||||.|||||:|:...::.||.|.|
Mouse   449 IRNNTLMGKPTEGALIALAMKMGLDGLQQDYIRKAEYPFSSEQKWMAVKCVHRTQQDRPEICFMK 513

  Fly   567 GALETLLPQCTKYQFGTQTVPLTKQNEAEFLAEAYEIGRKGLRVLALAKGRSMQDLIYCGLVGIT 631
            ||.|.::..||.|....||:.||:|....:..|...:|..||||||||.|..:..|.:.|||||.
Mouse   514 GAYEQVIKYCTTYNSKGQTLALTQQQRDLYQQEKARMGSAGLRVLALASGPELGQLTFLGLVGII 578

  Fly   632 DPPRPLVRESIEMLMQSGVRVKMVTGDAQETALAIDPSRRLQAVPTHAIPAWPTAGGVPLCSASA 696
            ||||..|:|::..|:.|||.:||:|||:||||:||
Mouse   579 DPPRTGVKEAVTTLIASGVSIKMITGDSQETAIAI------------------------------ 613

  Fly   697 CCSTNCLENAMKEIYLTALAQQGLPLVTANLIGIDTIHHQTLSGQEMDQMNEHQLDKVANNVSVF 761
                                        |:.:|:.:...|::||:|:|.|....|.::...|:||
Mouse   614 ----------------------------ASRLGLYSKTSQSVSGEEVDTMEVQHLSQIVPKVAVF 650

  Fly   762 YRVSPRHKLEIVKSLQRSGNIVGMTGDGVNDGVALKKADIGIAMGKNGTDVCKEAADMILVNDDF 826
            ||.|||||::|:||||::|.:|.||||||||.||||.||||:|||:.||||||||||||||:|||
Mouse   651 YRASPRHKMKIIKSLQKNGAVVAMTGDGVNDAVALKAADIGVAMGQTGTDVCKEAADMILVDDDF 715

  Fly   827 HTIIAAIEEGKGIFYNIRNFVRFQLSTSIAALALIALATLMDIANPLNAMQILWINIIMDGPPAQ 891
            .||::||||||||:.||:||||||||||||||.||:|||||:..|||||||||||||||||||||
Mouse   716 QTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTLISLATLMNFPNPLNAMQILWINIIMDGPPAQ 780

  Fly   892 SLGVEPVDHDVLKQKPRNVKQPMITKSVVVNVLLSASIIVLGTLWVFQREMADGTLGKTKRDTTM 956
            ||||||||.||:::.|||.|..::||::::.:|:|:.|||.|||:||.||:.|..:  |.|||||
Mouse   781 SLGVEPVDKDVIRKPPRNWKDSILTKNLILKILVSSIIIVCGTLFVFWRELRDNVI--TPRDTTM 843

  Fly   957 TFTCFVFFDMFNALSCRSQTKSVFTIGLTTNRMFLLAVAFSIIGQMLVVYFPPLQMVFQTEALTP 1021
            |||||||||||||||.||||||||.|||.:|:||..||..||:||:||:||||||.|||||:|:.
Mouse   844 TFTCFVFFDMFNALSSRSQTKSVFEIGLCSNKMFCYAVLGSIMGQLLVIYFPPLQKVFQTESLSI 908

  Fly  1022 YDIFFLVSLTSSVLVVSEIKKWFERTMER 1050
            .|:.||:.|||||.:||||.|..||:.|:
Mouse   909 LDLLFLLGLTSSVCIVSEIIKKVERSREK 937

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPoCk	NP_001262220.1	ATPase-IIA2_Ca	110..1049	CDD:130585	568/942 (60%)
		Cation_ATPase_N	112..179	CDD:279080	33/66 (50%)
		E1-E2_ATPase	191..425	CDD:278548	179/235 (76%)
		Cation_ATPase	496..579	CDD:289987	46/82 (56%)
		COG4087	<760..823	CDD:226572	48/62 (77%)
		Cation_ATPase_C	872..1044	CDD:279079	117/171 (68%)
Atp2c1	NP_001240760.1	ATPase-IIA2_Ca	57..936	CDD:130585	568/944 (60%)
		Cation_ATPase_N	60..128	CDD:279080	33/67 (49%)
		E1-E2_ATPase	152..372	CDD:278548	169/223 (76%)
		Cation_ATPase	443..526	CDD:289987	46/82 (56%)
		COG4087	589..712	CDD:226572	73/180 (41%)
		Cation_ATPase_C	759..931	CDD:279079	118/173 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831033
Domainoid	1	1.000	288	1.000	Domainoid score	I1559
eggNOG	1	0.900	-	-		E2759_KOG0202
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56672
Inparanoid	1	1.050	1063	1.000	Inparanoid score	I255
Isobase	1	0.950	-	0	Normalized mean entropy	S507
OMA	1	1.010	-	-		QHG53587
OrthoDB	1	1.010	-	-		D100699at2759
OrthoFinder	1	1.000	-	-		FOG0000231
OrthoInspector	1	1.000	-	-		otm43374
orthoMCL	1	0.900	-	-		OOG6_100158
Panther	1	1.100	-	-	O	PTHR42861
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R98
SonicParanoid	1	1.000	-	-		X1037
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750