Protein Alignment SPoCk and Atp12a

DIOPT Version :9

• Sequence 1: NP_001262220.1
• Gene: SPoCk / 40495
• FlyBaseID: FBgn0052451
• Length: 1062
• Species: Drosophila melanogaster
• Sequence 2: NP_619593.2
• Gene: Atp12a / 192113
• MGIID: 1926943
• Length: 1035
• Species: Mus musculus
• Alignment Length: 1159
• Identity: 303/1159 - (26%)
• Similarity: 504/1159 - (43%)
• Gaps: 269/1159 - (23%)

  Fly    37 RRSKIKGVDSKPNPQRTISHVKDSRAVPQNVKPGKVADMKDCKEPDED---------------NV 86
            |:::|..|:........::..||.:    ..|.||..|.:..|..:|:               ::
Mouse     3 RKTEIYSVELNGTKDVELADQKDDK----KFKGGKNKDSEPNKSQEEELKKELDLDDHRLSNTDL 63

  Fly    87 DQQNG-NIIQTGLTLTPEMLLSTSESSTHSASEVAGRLQVDVRTGLKWTEAKYRAKIIGHNELLL 150
            :|:.| |||| ||             |:..|:|:..|                    .|.|.|..
Mouse    64 EQKYGTNIIQ-GL-------------SSIRAAELLAR--------------------DGPNALTP 94

  Fly   151 VAEDPTWKKYIEQFRNPL-ILLLLGSAL--VSVIMKQFDDAVSI------TIAILIVVTV---AF 203
            ..:.|...|:::|..... |||.:|:||  ::.:::......|:      .|.:|:|:..   |:
Mouse    95 PKQTPEIIKFLKQMVGGFSILLWIGAALCWIAYVIQYVSSTASLDNVYLGAILVLVVILTGIFAY 159

  Fly   204 IQEYRSEKSLEELKKLVPPECHCLREGRLDTFLARELVPGDIVHLNVGDRVPADVRLFEAVDLSI 268
            .||.:|...:....|::|.:...:|:.......|.:||.||:|.:..||::|||:||..:....:
Mouse   160 YQEAKSTNIMASFSKMIPQQALVIRDAEKKIIPAEQLVVGDVVEIKGGDQIPADIRLVFSQGCKV 224

  Fly   269 DESSFTGETEPARKITDVLLNNTNVKDHSN---MKNIAFMGTLVRCGNGKGIVVSTGERSEFGEV 330
            |.||.|||:||..:.|:.        .|.|   .|||.|..|....|...|||::||:|:..|.:
Mouse   225 DNSSLTGESEPQARSTEF--------THENPLETKNIGFYSTTCLEGTATGIVINTGDRTIIGRI 281

  Fly   331 FKMMQAEEAPKTPLQKSMDILGAQLSFYSFLIIGVIMLLGWLQGKPLSEMFNIS----------- 384
            ..:.....:.|||       :..::..:..::..|.:.:|        .:|.|:
Mouse   282 ASLASGVGSEKTP-------IAIEIEHFVHIVAAVAVSVG--------VIFFITAVCMKYYVLDA 331

  Fly   385 ----VSLAVAAIPEGLPIVVTVTLALGVMRMAKRNSIVKKLPTVETLGCVNVICSDKTGTLTKNE 445
                :|:.||.:||||...|||||:|...||||:|.:||.|..|||||..::||||||||||:|.
Mouse   332 IIFLISIIVANVPEGLLATVTVTLSLTAKRMAKKNCLVKNLEAVETLGSTSIICSDKTGTLTQNR 396

  Fly   446 MT-ATIIITSDGYMADVTGAGYNDQGEIHIRHCNNVEMAKTNITNLLEIGAVCNNAYIQNG---- 505
            || |.:...:..::|| |......|.         .:.:.....:|.:|..:||.|..:.|
Mouse   397 MTVAHLWFDNQIFVAD-TSENQTKQA---------FDQSSGTWASLSKIITLCNRAEFRPGQESV 451

  Fly   506 -----TLLGQPTEGALV---AVAMKNGMYATAENYVRIQEYPFSSEQKMMAVKCIHKYN--NNKE 560
                 .::|..:|.||:   .|.:.:.|.....|: ::.|.||:|..|...  .||:..  |:|.
Mouse   452 PIMKRVVVGDASETALLKFSEVILGDVMDIRKRNH-KVAEIPFNSTNKFQL--SIHETEDPNDKR 513

  Fly   561 EIFFAKGALETLLPQCTKYQFGTQTVPLTKQNEAEFLAEAYEIGRKGLRVLA-----LAKGRSMQ 620
            .:...|||.|.:|.:|:......|..||.|.:...|.....|:|..|.|||.     |...:..|
Mouse   514 FLMVMKGAPERILEKCSTIMINGQEQPLDKSSADAFHTAYMELGGLGERVLGFCHLYLPADKFPQ 578

  Fly   621 --------------DLIYCGLVGITDPPRPLVRESIEMLMQSGVRVKMVTGDAQETALAIDPSRR 671
                          :|.:.||:.:.||||..|.:::.....:|::|.|||||
Mouse   579 SYTFDVDSINFPTSNLCFVGLLSMIDPPRSTVPDAVSKCRSAGIKVIMVTGD------------- 630

  Fly   672 LQAVPTHAIPAWPTAGGVPLCSASACCSTNCLENAMKEIYLTALAQQGLPLVTANLIGIDTIHHQ 736
                  |.|.|...|..|.:.||    :...:|:..|.                ..|.::.::.:
Mouse   631 ------HPITAKAIAKSVGIISA----NNETVEDIAKR----------------RNIAVEQVNKR 669

  Fly   737 -----TLSGQEMDQMNEHQLDKVANNVS--VFYRVSPRHKLEIVKSLQRSGNIVGMTGDGVNDGV 794
                 .::|.|:..|...|||::..|..  ||.|.||:.||.||:..||...:|.:|||||||..
Mouse   670 EAKAAVVTGMELKDMTPEQLDELLINYQEIVFARTSPQQKLIIVEGCQRQDAVVAVTGDGVNDSP 734

  Fly   795 ALKKADIGIAMGKNGTDVCKEAADMILVNDDFHTIIAAIEEGKGIFYNIRNFVRFQLSTSIAALA 859
            ||||||||||||..|:|..|.||||:|::|:|.:|:..:|||:.||.|::..:.:.|:.:||.|.
Mouse   735 ALKKADIGIAMGIAGSDAAKNAADMVLLDDNFASIVTGVEEGRLIFDNLKKTIAYTLTKNIAELC 799

  Fly   860 LIALATLMDIANPLNAMQILWINIIMDGPPAQSLGVEPVDHDVLKQKPRNVKQP-MITKSVVVNV 923
            ...:..:..:..|:..:.||:|::..|..|:.:|..|..:.|::.:|||:.|:. ::.|.:.:..
Mouse   800 PFLIYIVAGLPLPIGTITILFIDLGTDIIPSIALAYEKAESDIMNRKPRHKKKDRLVNKQLAIYS 864

  Fly   924 LL------------------------SASIIVLGTLWV-----------------FQREMADGTL 947
            .|                        ..|:|.|...|.                 :||:..:.|
Mouse   865 YLHIGLMQALGGFLVYFTVYAQQGFWPTSLINLRVSWETDDINDLEDSYGQEWTRYQRKYLEWT- 928

  Fly   948 GKTKRDTTMTFTCFVFFDMFNALSCRSQTKSVFTIGLTTNRMFLLAVAFSIIGQMLVVYFPPLQM 1012
                 .:|..|...:...:.:.:..:::..|:|..||..|::    :...||.|::|.    |.:
Mouse   929 -----GSTAFFVAIMVQQIADLIIRKTRRNSIFQQGLFRNKV----IWVGIISQIIVA----LVL 980

  Fly  1013 VFQTEALTPYDI------FFLVSLTSSVL--VVSEIKKWFERT-----MERKMY 1053
            .:...::|....      ::.|::..::|  |..|::|.|.|.     .::.||
Mouse   981 SYGLGSVTALSFTMLRAQYWFVAVPHAILIWVYDEMRKLFIRLYPGSWWDKNMY 1034

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SPoCk	NP_001262220.1	ATPase-IIA2_Ca	110..1049	CDD:130585	282/1064 (27%)
		Cation_ATPase_N	112..179	CDD:279080	16/69 (23%)
		E1-E2_ATPase	191..425	CDD:278548	75/260 (29%)
		Cation_ATPase	496..579	CDD:289987	26/96 (27%)
		COG4087	<760..823	CDD:226572	39/62 (63%)
		Cation_ATPase_C	872..1044	CDD:279079	40/221 (18%)
Atp12a	NP_619593.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	22..49		8/30 (27%)
		ATPase-IIC_X-K	40..1035	CDD:273445	294/1118 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831039
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.850