DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SPoCk and catp-5

DIOPT Version :9

Sequence 1:	NP_001262220.1	Gene:	SPoCk / 40495	FlyBaseID:	FBgn0052451	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	NP_001309699.1	Gene:	catp-5 / 181067	WormBaseID:	WBGene00019493	Length:	1202	Species:	Caenorhabditis elegans

Alignment Length:	1120	Identity:	234/1120 - (20%)
Similarity:	433/1120 - (38%)	Gaps:	264/1120 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 LSTSESSTHSASEVAGRLQVDVRTGLKWTEAKYRAKIIGHNELLLVAEDPTWKKYIEQFRNPLIL 170
            |:.::..:.:...:..:|.:|| .|||..:.....||...|.|.|..             .|:::
Worm   166 LNPADMDSAAPFNIYQKLTLDV-IGLKEQDVIASRKIYNMNALALAL-------------TPILV 216

  Fly   171 LLLGSALVSVIMKQ-------FDDAVSITIAILIVVTV--AFIQEYRSEKSLEELKKLVPPECHC 226
            :|....|....:.|       :.|..:...::::::||  |.:..|:.....:.::.:|......
Worm   217 ILFKEVLGPFYLFQCFSVALWYSDNYAYYASVIVIITVGSAAVAVYQMRAQEKRIRNMVGDTISV 281

  Fly   227 L--REGRLDTFLARELVPGDIVHLNVGDRV-PADVRLFEAVDLSIDESSFTGETEPARKIT---- 284
            :  |:|...|..|.|:||.||:.|.....: |.|..|.... :.::|:..|||:.|..|.:
Worm   282 IVRRDGHDITIDASEIVPMDILILPSNTFILPCDCLLMNGT-VIVNEAMLTGESVPVTKASLKEA 345

  Fly   285 -----DVLLNNTNVKDHSNMKNIAFMGTLV-RCGNGKG-----IVVSTGERSEFGEVFK-MMQAE 337
                 ::.|::    :|:  ::..|.||.| :..|.||     .|:.||..:..|::.: :|..:
Worm   346 DECGPEIRLSS----EHN--RHTLFSGTTVLQTRNYKGQPVMARVIRTGFSTLKGQLVRSIMYPK 404

  Fly   338 EAPKTPLQKSMDILGAQLSFYSFLIIGVIMLLGWL--------QGKPLSEMFNISVSLAVAAIPE 394
            ...|..|:..|..:         |::|.|.|:|::        :|:.|..:...|:.:....:|.
Worm   405 PQEKEALKDVMVFI---------LVLGFIALIGFIYTVIEMVSRGESLKHIIIRSLDIITIVVPP 460

  Fly   395 GLPIVVTVTLALGVMRMAKRNSIVKKLPTVETLGCVNVICSDKTGTLTKNEMTATIIITSDGYMA 459
            .||..::|.:.....|:.|:........||...|.:||.|.|||||||::.:....:
Worm   461 ALPAAMSVGIINANSRLKKKKIFCTSPTTVNVCGLINVACFDKTGTLTEDGLDFNCL-------- 517

  Fly   460 DVTGAGYNDQGE----IHIRHCNNVEMAKTNIT-NLLEIGAVCNNAYIQNGTLLGQPTEGALVAV 519
              .....|:.|:    ......:.|:::..|.. |::...|.|::....:|||.|.|.|  |:.|
Worm   518 --KAIRKNEDGKPEFTSEFEELDPVKLSAENANLNIVVAAASCHSLTRIDGTLHGDPLE--LILV 578

  Fly   520 AMKNGMYATAEN-------------------------------YVRIQEYPFSSE-QKMMAVKCI 552
            .....:...|.|                               |..|:::||:|. |:|..:...
Worm   579 EKSKWIIEEAVNSDEETQDFDTVQPTVLRPPPEQATYHPENNEYSVIKQHPFNSALQRMSVIIST 643

  Fly   553 HKYNNNKEEIFFAKGALETLLPQCTKYQFGTQTVPLTKQNEAEFLAEAYEIGRKGLRVLALAK-- 615
            ...::..:.:.|.||:.|.:...|.     ..|:|      .:::....|..::|.|::|:|.
Worm   644 PSEHSAHDMMVFTKGSPEMIASLCI-----PDTIP------EDYMEVVDEYAQRGFRLIAVASKA 697

  Fly   616 -----GRSMQ--------DLIYCGLVGITDPPRPLVRESIEMLMQSGVRVKMVTGDAQETALA-- 665
                 .::::        :|.:.||:.:.:..:.:....|..|..:.:|..|||||...||::
Worm   698 VHLNFAKALKTPRDIMESELEFLGLIVMENRLKDVTLSVINELSVANIRCVMVTGDNLLTAMSVA 762

  Fly   666 -----IDPSRRLQAVPTHAIPAWPTAGGVPL-CSASACCSTNCLEN-------AMKEIYLTALAQ 717
                 |.|:::...: ||:.......|...| ...|...|.|.::.       ..|.:..||..|
Worm   763 RECGIIRPTKKAFLI-THSKTEKDPLGRTKLFIKESVSSSENDIDTDSEVRAFDRKAVLRTATYQ 826

  Fly   718 QGLPLVTANLIGIDTIHHQTLSGQEMDQMNEHQLDKVANNVSVFYRVSPRHKLEIVKSLQRSGNI 782
            ..:...|.::|   |..:..|            :|::.....|:.|::|..|.:::.:||..|..
Worm   827 MAIAGPTYSVI---THEYPEL------------VDRITAMCDVYARMAPDQKAQLIGALQEIGAK 876

  Fly   783 VGMTGDGVNDGVALKKADIGIAMGKNGTDVCKEAADMILVNDDFHTIIAAIEEGKGIFYNIRNFV 847
            |.|.|||.||..|||.|..||::.:....:   ||.......|...:...|:||:...     ..
Worm   877 VSMCGDGANDCAALKAAHAGISLSQAEASI---AAPFTSNVPDIRCVPTVIKEGRCAL-----VT 933

  Fly   848 RFQLSTSIAALALIALATLMDIANP---LNAMQILWINII-----------------MDG-PPAQ 891
            .:.:|..:||.:|....::|.:.|.   ::..|.|:|:::                 :.| ||.:
Worm   934 SYAVSKYMAAYSLNEFLSVMLLYNDGTNISDGQFLYIDLVLITLVALFLGNTEASRKLSGIPPPR 998

  Fly   892 SLGVEPVDHDVLKQKPRNVKQPMITKSVVVNVLLSASIIVLGTLW-VFQREMADGTLGKTKRDTT 955
            .|........|..|...|:    ||::       :..::|.|..| |...|..|.|  .|...||
Worm   999 RLATSAFYFSVFGQMFFNI----ITQT-------TGYLLVRGQSWYVPNPEELDNT--TTMIGTT 1050

  Fly   956 MTFT--CFVFFDMFNALSCRSQTKSVFTIGLTTNRMFL-----LAVAFSIIGQML----VVYFPP 1009
            :.||  |......|.........:||||..|....:|:     :.:.|:.:|.::    .||.|.
Worm  1051 VFFTSCCMYLGYAFVYSKGHPYRRSVFTNWLLCGIIFVIGAINMVMIFTNMGFLMNLMGFVYVPS 1115

  Fly  1010 LQMVFQTEALT--------PYDIFFL-----------------------VSLTSSVL-VVSEIKK 1042
            ..|.|...|::        .|:.||:                       :|....:| .:....:
Worm  1116 TSMRFILLAISLAGVFLSLLYEHFFVEKVVAIHFESYLRQRRLRNGDPSLSAYEKILAAIGSSPR 1180

  Fly  1043 WFE------RTMERK 1051
            |||      ::::||
Worm  1181 WFEDEINLSKSIDRK 1195

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPoCk	NP_001262220.1	ATPase-IIA2_Ca	110..1049	CDD:130585	231/1112 (21%)
		Cation_ATPase_N	112..179	CDD:279080	14/66 (21%)
		E1-E2_ATPase	191..425	CDD:278548	56/262 (21%)
		Cation_ATPase	496..579	CDD:289987	23/114 (20%)
		COG4087	<760..823	CDD:226572	22/62 (35%)
		Cation_ATPase_C	872..1044	CDD:279079	45/236 (19%)
catp-5	NP_001309699.1	P-ATPase-V	52..1125	CDD:273738	223/1048 (21%)
		P5-ATPase	52..154	CDD:289194
		E1-E2_ATPase	247..490	CDD:278548	55/258 (21%)
		Cation_ATPase	<614..667	CDD:289987	11/52 (21%)
		HAD_like	<846..910	CDD:304363	23/66 (35%)
		Cation_ATPase_C	966..1136	CDD:295563	40/182 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910