Protein Alignment SPoCk and mca-1

DIOPT Version :9

• Sequence 1: NP_001262220.1
• Gene: SPoCk / 40495
• FlyBaseID: FBgn0052451
• Length: 1062
• Species: Drosophila melanogaster
• Sequence 2: NP_501709.2
• Gene: mca-1 / 177795
• WormBaseID: WBGene00003151
• Length: 1252
• Species: Caenorhabditis elegans
• Alignment Length: 1180
• Identity: 301/1180 - (25%)
• Similarity: 488/1180 - (41%)
• Gaps: 295/1180 - (25%)

  Fly    20 GSTVLIESPTTSSGVRNRRSKIK-----GVDSKPNPQRTISHVKDSRAVPQNVKPGKVADMKD-C 78
            |:..::...|...||.....|:|     |::.:........||..:..:|.....|.|..:.| |
 Worm    55 GAEAIVRLSTEHEGVEGLCKKLKTDSLVGLNGEQADLDRRRHVYGANTIPPAKSKGFVRLVLDAC 119

  Fly    79 KEPDEDNVDQQNGNIIQTGLTLTPEMLLSTSESSTHSASEVAGRLQVDVRTGLKWTEAKYRAKII 143
            |:|.         .:|   |.|:..:.|:.|.....||:|.|.:..|:..|          |.|:
 Worm   120 KDPT---------LVI---LVLSGFINLALSFYEPTSAAEDATQHLVNATT----------AAIL 162

  Fly   144 GHNELLLVAEDPTWKKYIEQFRNPLILLLLGSALVSVIMKQFDDAVSITIAILIVVTVAFIQEYR 208
            .:...:...|.|:...              |:|.:        :.|:|.:.:::||.|..:.:|.
 Worm   163 ANGTFMSTTEAPSEGH--------------GTAWI--------EGVAILLCVIVVVLVTAVNDYS 205

  Fly   209 SEKSLEELKKLVP--PECHCLREGRLDTFLARELVPGDIVHLNVGDRVPADVRLFEAVDLSIDES 271
            .|:....|::.:.  .:...:|.|........:||.|||..:..||.:|||..|.::.||.||||
 Worm   206 KERQFRSLQEKIETGQKFSVIRNGEAIDVPVSDLVVGDIARVKYGDLLPADGFLIQSNDLKIDES 270

  Fly   272 SFTGETEPARKITD---VLLNNTNVKDHSNMKNIAFMGTLVRCGNGKGIVVSTGERSEFGEVFKM 333
            |.|||::..:|..:   |||:                ||....|:||.::.:.|..|:.|.:..:
 Worm   271 SLTGESDHIKKSIESDPVLLS----------------GTYAMEGSGKMLITAVGVNSQTGIIMTL 319

  Fly   334 MQAEEA----------------------------------------PKTPLQKSMDILGAQLSF- 357
            :.|.:|                                        .|:.||..:..|..|:.:
 Worm   320 LGAGKAGIGDDDSTSTSSSSSSSSSSSGSSSNGSSDSSKSGDDDLTAKSVLQAKLSKLALQIIYC 384

  Fly   358 -YSFLIIGVIMLL---------------GWLQGKPLSEMFNISVSLAVAAIPEGLPIVVTVTLAL 406
             .:..||.:|:|:               ..:..:...:.|.|:|::.|.:||||||:.:.:.|..
 Worm   385 GTTIAIIALIVLVTRFCLDHYVFEKNEFSLVDIQMFVKFFIIAVTILVISIPEGLPLAIALALTY 449

  Fly   407 GVMRMAKRNSIVKKLPTVETLGCVNVICSDKTGTLTKNEMTATIIITSDGYMADVTGAGYNDQGE 471
            .|.:|...|::|:.|...||:|....||||||||||.|.||..        .:.:.|..|..| |
 Worm   450 SVRKMMHDNNLVRHLDACETMGNATSICSDKTGTLTTNRMTVV--------QSYINGNHYTSQ-E 505

  Fly   472 IHIRHCNNVEMAKTNITNLLEIGAVCNNAYIQNGTL------LGQPTE-GALVAVAMKNGMYATA 529
            ......|........:...:.:....|:..::....      ||..|| |.|..|....|.||..
 Worm   506 AQPHGANLPGSTGPILMEAISVNCAYNSMIVEPTKAGEQIQQLGNKTECGLLGFVNRLGGDYAAI 570

  Fly   530 E----NYVRIQEYPFSSEQKMMAVKCIHKYNNNKEEI---FFAKGALETLLPQCTKYQFGTQTVP 587
            .    .:...:.|.|:|.:|.|..  :..|..|.:.|   .:.|||.|.:|.:|| |..|:...|
 Worm   571 RKKFPEHDLTKVYTFNSSRKCMMT--VVPYAENGQNIGYRVYCKGASEIVLGRCT-YLIGSDGKP 632

  Fly   588 --LTKQNEAEFLAE-AYEIGRKGLRVLALA------KG-RSM-----------------QDLIY- 624
              ||.....|..:. .:|:...|||.:.:|      || |.:                 :|.:|
 Worm   633 HQLTGDRLKEITSTIIHEMANSGLRTICVAYKTIIKKGTRDVEKTEIEFAEDSDIDWDDEDAMYQ 697

  Fly   625 ----CGLVGITDPPRPLVRESIEMLMQSGVRVKMVTGDAQETALAIDPSRRLQAVPTHAIPAWPT 685
                ..:.||.||.||.|..:|....::|:.|:|||||...||.||
 Worm   698 NFTGIAICGIQDPVRPEVPVAISKCKKAGITVRMVTGDNIMTARAI------------------- 743

  Fly   686 AGGVPLCSASACCSTNCLENAMKEIYLTALAQQGLPLVTANLIGIDTIHHQTLSGQEMDQ----- 745
                    |.:|   ..||.                       |.|.:   .|.|:|.::
 Worm   744 --------AMSC---KILEP-----------------------GEDFL---ALEGKEFNERIRDE 771

  Fly   746 ---MNEHQLDKVANNVSVFYRVSPRHKLEIVKSL-------QRSGNIVGMTGDGVNDGVALKKAD 800
               :::.:||::...:.|..|..|..|..:||.:       ||  .||.:||||.|||.||||||
 Worm   772 NGKVSQAKLDEIWPRLRVLARAQPADKYTLVKGIIDSKATPQR--EIVAVTGDGTNDGPALKKAD 834

  Fly   801 IGIAMGKNGTDVCKEAADMILVNDDFHTIIAAIEEGKGIFYNIRNFVRFQLSTSIAAL--ALIAL 863
            :|.|||..||||.|||:|:||.:|:|.:|:.|:..|:.::.:|..|::|||:.::.|:  |.:..
 Worm   835 VGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVITAFVGA 899

  Fly   864 ATLMDIANPLNAMQILWINIIMDGPPAQSLGVEPVDHDVLKQKPRNVKQPMITKSVVVNVLLSA- 927
            .|:.|  :||.|:.:||||:|||...:.:|..|....::|::||...|:.:|::::|.|:|..|
 Worm   900 VTVSD--SPLKAVHMLWINLIMDTLASLALATEQPTDELLERKPYGRKKSLISRTMVKNILCHAL 962

  Fly   928 -SIIVLGTLWVFQREMADGTLG-KT----------KRDTTMTFTCFVFFDMFNALSCRS--QTKS 978
             .:|::..::.:    .|...| ||          .:..|:.|..||...:||.::.|.  ..::
 Worm   963 YQLIIIFVIFFY----GDTIFGIKTGLYAPLFAPPSQHFTLVFNAFVMMTVFNEINARKVHGERN 1023

  Fly   979 VFTIGLTTNRMFLLAVAFSIIGQMLVVYFPPLQMVFQTEALTPYDIFFLVSLTSSVLVVSEI--- 1040
            ||. ||.:||:|.:....:.|.|:::|.|....  |.|..||.......:.|..|.|:..:|
 Worm  1024 VFK-GLASNRVFCVIWVTTFIAQIIIVQFGGAW--FSTAPLTLQQWIVCLVLGFSTLIWGQIVAT 1085

  Fly  1041 -------KKW 1043
                   |.|
 Worm  1086 IPSKKLPKAW 1095

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SPoCk	NP_001262220.1	ATPase-IIA2_Ca	110..1049	CDD:130585	280/1084 (26%)
		Cation_ATPase_N	112..179	CDD:279080	12/66 (18%)
		E1-E2_ATPase	191..425	CDD:278548	69/295 (23%)
		Cation_ATPase	496..579	CDD:289987	26/96 (27%)
		COG4087	<760..823	CDD:226572	37/69 (54%)
		Cation_ATPase_C	872..1044	CDD:279079	54/197 (27%)
mca-1	NP_501709.2	ATPase-IIB_Ca	46..1087	CDD:273668	299/1170 (26%)
		Cation_ATPase_N	66..133	CDD:279080	17/78 (22%)
		E1-E2_ATPase	225..468	CDD:278548	62/258 (24%)
		Cation_ATPase	532..624	CDD:289987	26/94 (28%)
		Cation_ATPase_C	905..1083	CDD:279079	51/184 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920