DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SPoCk and sca-1

DIOPT Version :9

Sequence 1:	NP_001262220.1	Gene:	SPoCk / 40495	FlyBaseID:	FBgn0052451	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	NP_499386.1	Gene:	sca-1 / 176512	WormBaseID:	WBGene00004736	Length:	1059	Species:	Caenorhabditis elegans

Alignment Length:	1065	Identity:	321/1065 - (30%)
Similarity:	502/1065 - (47%)	Gaps:	232/1065 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 GHNELLLVAEDPTWKKYIEQFRNPLILLLLGSALVSVIMKQF----DDAVSIT------IAILIV 198
            |.||:........|:..:|||.:.|:.:||.:|::|.::..|    |...::|      :.:||:
Worm    36 GENEMPAEEGKSLWELILEQFDDLLVKILLLAAIISFVLALFEEHEDQTEAVTAFVEPFVILLIL 100

  Fly   199 V---TVAFIQEYRSEKSLEELKKLVPPECHCLREGR--LDTFLARELVPGDIVHLNVGDRVPADV 258
            :   ||...||..:|.::|.||:..|.....:|.|.  :....|:||||||:|.::|||::|||:
Worm   101 IANATVGVWQERNAESAIEALKEYEPEMAKVIRSGHHGIQMVRAKELVPGDLVEVSVGDKIPADL 165

  Fly   259 RLFE--AVDLSIDESSFTGETEPARKITDVLLNNTNVKD----HSNMKNIAFMGTLVRCGNGKGI 317
            ||.:  :..:.||:|..|||:....|.||      :|.|    :.:.||..|.||.|..|..:||
Worm   166 RLVKIYSTTIRIDQSILTGESVSVIKHTD------SVPDPRAVNQDKKNCLFSGTNVASGKARGI 224

  Fly   318 VVSTGERSEFGEVFKMMQAEEAPKTPLQKSMDILGAQLSFYSFLIIGVIMLL------------- 369
            |..||..:|.|::...|...|..|||||:.:|..|.|||    .:|.||.:.
Worm   225 VFGTGLTTEIGKIRTEMAETENEKTPLQQKLDEFGEQLS----KVISVICVAVWAINIGHFNDPA 285

  Fly   370 ---GWLQGKPLSEMFNISVSLAVAAIPEGLPIVVTVTLALGVMRMAKRNSIVKKLPTVETLGCVN 431
               .|::|  ....|.|:|:|||||||||||.|:|..||||..||||:|:||:.||:||||||.:
Worm   286 HGGSWVKG--AIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTS 348

  Fly   432 VICSDKTGTLTKNEMTATIIITSDGYMAD--------VTGAGYNDQGEIHI--RHCNNVEMAKTN 486
            |||||||||||.|:|:.:.:..:.....|        ::|:.|...|::..  |..|.......:
Worm   349 VICSDKTGTLTTNQMSVSKMFIAGQASGDNINFTEFAISGSTYEPVGKVSTNGREINPAAGEFES 413

  Fly   487 ITNLLEIGAVCNNAYIQ-NGT-----LLGQPTEGALVAVAMKNGMYATAE------------NYV 533
            :|.|..|.|:||::.:. |.|     .:|:.||.||:.:|.|..::.|::            |.|
Worm   414 LTELAMICAMCNDSSVDYNETKKIYEKVGEATETALIVLAEKMNVFGTSKAGLSPKELGGVCNRV 478

  Fly   534 RIQEY------PFSSEQKMMAVKCIHKYNNNKEEIFFAKGALETLLPQCTKYQFGTQTVPLTKQN 592
            ..|::      .||.::|.|:..|......:..:: |.|||.|.:|.:||..:...|.||||...
Worm   479 IQQKWKKEFTLEFSRDRKSMSAYCFPASGGSGAKM-FVKGAPEGVLGRCTHVRVNGQKVPLTSAM 542

  Fly   593 EAEFLAEA--YEIGRKGLRVLALAK------------------GRSMQDLIYCGLVGITDPPRPL 637
            ..:.:.:.  |..||..||.|||..                  .:..||:.:.|:||:.||||..
Worm   543 TQKIVDQCVQYGTGRDTLRCLALGTIDTPVSVSNMNLEDSTQFVKYEQDITFVGVVGMLDPPRTE 607

  Fly   638 VRESIEMLMQSGVRVKMVTGDAQETALAIDPSRRLQAVPTHAIPAWPTAGGVPLCSASACCSTNC 702
            |.:||:....:|:||.|:|||.:.||.||  .||:
Worm   608 VSDSIKACNHAGIRVIMITGDNKNTAEAI--GRRI------------------------------ 640

  Fly   703 LENAMKEIYLTALAQQGLPLVTANLIGIDTIHHQTLSGQEMDQMNEHQLDKVANNVSVFYRVSPR 767
                            ||.....:..|      :..:|:|.|.:...|..:......:|.||.|.
Worm   641 ----------------GLFGENEDTTG------KAYTGREFDDLPPEQQSEACRRAKLFARVEPS 683

  Fly   768 HKLEIVKSLQRSGNIVGMTGDGVNDGVALKKADIGIAMGKNGTDVCKEAADMILVNDDFHTIIAA 832
            ||.:||..||..|.|..||||||||..|||||:|||:|| :||.|.|.|::|:|.:|:|.:|::|
Worm   684 HKSKIVDILQSQGEITAMTGDGVNDAPALKKAEIGISMG-SGTAVAKSASEMVLADDNFASIVSA 747

  Fly   833 IEEGKGIFYNIRNFVRFQLSTSIAALALIALATLMDIANPLNAMQILWINIIMDGPPAQSLGVEP 897
            :|||:.|:.|::.|:|:.:|:::..:..|.:...:.|...|..:|:||:|::.||.||.:||..|
Worm   748 VEEGRAIYNNMKQFIRYLISSNVGEVVSIFMVAALGIPEALIPVQLLWVNLVTDGLPATALGFNP 812

  Fly   898 VDHDVLKQKPRNVKQPMITKSVVVNVLLSASIIVLGTLWVFQREMADG------TLG-------- 948
            .|.|::.:.||:....:|:.                  |:|.|.:|.|      |:|
Worm   813 PDLDIMDRHPRSANDGLISG------------------WLFFRYLAVGTYVGVATVGASMWWFLL 859

  Fly   949 ------------------KTKRDTTMTFTCFVFFD---------------MFNALSCRSQTKSVF 980
                              :.:.|......|.||.|               |.||::..|:.:|:.
Worm   860 YEEGPQITYYQLTHWMRCEIEPDNFADLDCAVFEDNHPNAMALSVLVTIEMLNAINSLSENQSLL 924

  Fly   981 TIGLTTNRMFLLAVAFSIIGQMLVVYFPPLQMVFQTEALTPYDIFFLVSLTSSVLVVSEIKKWFE 1045
            .:....|...:.|::.|:....:::|...:..:||...|...:...::.::..||::.||.|:..
Worm   925 VMPPWKNIWLMAAISLSMSLHFVILYVDIMATIFQITPLNWVEWIAVLKISLPVLLLDEILKFIA 989

  Fly  1046 R--------TMERKMYSTRSELDFV 1062
            |        |:..|..|..|.|.:|
Worm   990 RNYIDGKPETVGAKARSAISLLAWV 1014

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPoCk	NP_001262220.1	ATPase-IIA2_Ca	110..1049	CDD:130585	316/1050 (30%)
		Cation_ATPase_N	112..179	CDD:279080	11/34 (32%)
		E1-E2_ATPase	191..425	CDD:278548	101/266 (38%)
		Cation_ATPase	496..579	CDD:289987	28/106 (26%)
		COG4087	<760..823	CDD:226572	37/62 (60%)
		Cation_ATPase_C	872..1044	CDD:279079	46/218 (21%)
sca-1	NP_499386.1	Cation_ATPase_N	4..71	CDD:279080	11/34 (32%)
		ATPase-IIA1_Ca	52..990	CDD:273452	310/1023 (30%)
		E1-E2_ATPase	95..342	CDD:278548	100/258 (39%)
		Cation_ATPase	423..529	CDD:289987	28/106 (26%)
		HAD	<607..713	CDD:289480	44/159 (28%)
		Cation_ATPase_C	785..988	CDD:279079	46/220 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	1	1.010	-	-		D100699at2759
OrthoFinder	1	1.000	-	-		FOG0000231
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100158
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.830