DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SPoCk and Atp2c2

DIOPT Version :9

Sequence 1:	NP_001262220.1	Gene:	SPoCk / 40495	FlyBaseID:	FBgn0052451	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	NP_604457.1	Gene:	Atp2c2 / 171496	RGDID:	620647	Length:	944	Species:	Rattus norvegicus

Alignment Length:	957	Identity:	515/957 - (53%)
Similarity:	667/957 - (69%)	Gaps:	71/957 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 LSTSESSTHSASEVAGRLQVDVRTGLKWTEAKYRAKIIGHNELLLVAEDPTWKKYIEQFRNPLIL 170
            |...|:...|..|:|....||:.:||.......|..:.|.||.:....:|.||||::||||||||
  Rat    50 LPPREACKCSKEELARTFHVDLDSGLSEFAVAQRRLVHGWNEFVTDNTEPVWKKYLDQFRNPLIL 114

  Fly   171 LLLGSALVSVIMKQFDDAVSITIAILIVVTVAFIQEYRSEKSLEELKKLVPPECHCLREGRLDTF 235
            |||||::|||:.|:::||:||.:|:||||||.||||||||||||||.|||||||:|||:|:|...
  Rat   115 LLLGSSVVSVLTKEYEDAISIALAVLIVVTVGFIQEYRSEKSLEELTKLVPPECNCLRDGKLRHM 179

  Fly   236 LARELVPGDIVHLNVGDRVPADVRLFEAVDLSIDESSFTGETEPARKITDVLLNNTNVKDHSNMK 300
            |||:|||||:|.|::|||:|||:||.|..||.:||||||||.||..|....|...   .|.|.:.
  Rat   180 LARDLVPGDVVSLSMGDRIPADIRLTEVTDLLVDESSFTGEVEPCSKTDSPLAGG---GDLSTLS 241

  Fly   301 NIAFMGTLVRCGNGKGIVVSTGERSEFGEVFKMMQAEEAPKTPLQKSMDILGAQLSFYSFLIIGV 365
            |:.||||||:||.|:|:|:.|||:|:||||||||:|||.||||||||||.||.||:.:||.|||:
  Rat   242 NVVFMGTLVQCGKGQGVVIGTGEQSQFGEVFKMMRAEETPKTPLQKSMDKLGKQLTVFSFGIIGL 306

  Fly   366 IMLLGWLQGKPLSEMFNISVSLAVAAIPEGLPIVVTVTLALGVMRMAKRNSIVKKLPTVETLGCV 430
            :||:||:|||||..||.|.||||||||||||||||.|||.|||:||||:..||||||.||||||.
  Rat   307 LMLVGWVQGKPLLSMFTIGVSLAVAAIPEGLPIVVMVTLVLGVLRMAKKRVIVKKLPIVETLGCC 371

  Fly   431 NVICSDKTGTLTKNEMTATIIITSDGYMADVTGAGYNDQGEIHIRHCNNV--EMAKTNITNLLEI 493
            ||||||||||||.||||||.::||||:.|:|:|.||:.:|.:.:.....|  |.:..::..|:|.
  Rat   372 NVICSDKTGTLTANEMTATQLVTSDGFHAEVSGIGYSGEGTVCLLPSKEVIKEFSNVSVGKLVEA 436

  Fly   494 GAVCNNAYIQNGTLLGQPTEGALVAVAMKNGMYATAENYVRIQEYPFSSEQKMMAVKCIHKYNNN 558
            |.|.|||.::...::|||||||||.:|||..:.:..::|:|.:|.|||||||.|||:|..| |.:
  Rat   437 GCVANNAVVRKNAVMGQPTEGALVVLAMKMNLGSIKDSYIRKKEIPFSSEQKWMAVRCSLK-NED 500

  Fly   559 KEEIFFAKGALETLLPQCTKYQFGTQTVPLTKQNEAEFLAEAYEIGRKGLRVLALAKGRSMQDLI 623
            :|:::|.|||.|.::..|:.|..|...:|||.|.::....|..::|..||||||||.|..:..|.
  Rat   501 EEDVYFMKGAFEEVIHHCSTYNNGGIPLPLTPQQKSYCQQEEKKMGSLGLRVLALASGPELGRLT 565

  Fly   624 YCGLVGITDPPRPLVRESIEMLMQSGVRVKMVTGDAQETALAIDPSRRLQAVPTHAIPAWPTAGG 688
            :.|||||.||||..|:|:::.|.:|.|.||||||||.||||||..:
  Rat   566 FLGLVGIIDPPRAGVKEAVQALSESDVSVKMVTGDALETALAIGRT------------------- 611

  Fly   689 VPLCSASACCSTNCLENAMKEIYLTALAQQGLPLVTANLIGIDTIHHQTLSGQEMDQMNEHQLDK 753
            :.||....                                       :.:||:|::.|.:..|..
  Rat   612 IGLCDEKL---------------------------------------KAMSGEEVEGMEQDALAA 637

  Fly   754 VANNVSVFYRVSPRHKLEIVKSLQRSGNIVGMTGDGVNDGVALKKADIGIAMGKNGTDVCKEAAD 818
            ....||||:|.||:||::|:|:||.||.||.||||||||.||||.||||||||:.||||.|||||
  Rat   638 RVRQVSVFFRTSPKHKVKIIKALQESGAIVAMTGDGVNDSVALKSADIGIAMGQTGTDVSKEAAD 702

  Fly   819 MILVNDDFHTIIAAIEEGKGIFYNIRNFVRFQLSTSIAALALIALATLMDIANPLNAMQILWINI 883
            ||||:|||..|::|:||||||||||:||||||||||||||:||.|:|:.::.||||||||||:||
  Rat   703 MILVDDDFSAIMSAVEEGKGIFYNIKNFVRFQLSTSIAALSLITLSTVCNLPNPLNAMQILWVNI 767

  Fly   884 IMDGPPAQSLGVEPVDHDVLKQKPRNVKQPMITKSVVVNVLLSASIIVLGTLWVFQREMADGTLG 948
            ||||||||||||||||.|.||:.||:||..::.:::::.:|:||::|:.|||::|.||:.:...
  Rat   768 IMDGPPAQSLGVEPVDRDALKRPPRSVKDTILNRALILKILMSAAVILGGTLFIFWREIPENRT- 831

  Fly   949 KTKRDTTMTFTCFVFFDMFNALSCRSQTKSVFTIGLTTNRMFLLAVAFSIIGQMLVVYFPPLQMV 1013
            .|.|.|||.||||||||:|||||||||||.:|.||...|||||.::..|::||:.|:|.||||.|
  Rat   832 STPRTTTMAFTCFVFFDLFNALSCRSQTKLIFEIGFFRNRMFLYSILGSLLGQLAVIYAPPLQKV 896

  Fly  1014 FQTEALTPYDIFFLVSLTSSVLVVSEIKKWFERTMERKMYSTRSELD 1060
            ||||.|:..|:..|..|.|||.::||:.|..|:      :.:|::.|
  Rat   897 FQTENLSALDLLLLTGLASSVFILSELLKLCEK------FCSRAKAD 937

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPoCk	NP_001262220.1	ATPase-IIA2_Ca	110..1049	CDD:130585	512/940 (54%)
		Cation_ATPase_N	112..179	CDD:279080	29/66 (44%)
		E1-E2_ATPase	191..425	CDD:278548	159/233 (68%)
		Cation_ATPase	496..579	CDD:289987	39/82 (48%)
		COG4087	<760..823	CDD:226572	47/62 (76%)
		Cation_ATPase_C	872..1044	CDD:279079	100/171 (58%)
Atp2c2	NP_604457.1	Interaction with ORAI1. /evidence=ECO:0000250\|UniProtKB:O75185	69..93		8/23 (35%)
Atp2c2	NP_604457.1	P-type_ATPase_SPCA	83..925	CDD:319779	502/904 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334767
Domainoid	1	1.000	234	1.000	Domainoid score	I2309
eggNOG	1	0.900	-	-		E2759_KOG0202
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1069	1.000	Inparanoid score	I234
OMA	1	1.010	-	-		QHG53587
OrthoDB	1	1.010	-	-		D100699at2759
OrthoFinder	1	1.000	-	-		FOG0000231
OrthoInspector	1	1.000	-	-		otm45444
orthoMCL	1	0.900	-	-		OOG6_100158
Panther	1	1.100	-	-	LDO	PTHR42861
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1037
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.810