DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SPoCk and Atp12a

DIOPT Version :9

Sequence 1:	NP_001262220.1	Gene:	SPoCk / 40495	FlyBaseID:	FBgn0052451	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	NP_598201.2	Gene:	Atp12a / 171028	RGDID:	620569	Length:	1036	Species:	Rattus norvegicus

Alignment Length:	1161	Identity:	312/1161 - (26%)
Similarity:	512/1161 - (44%)	Gaps:	272/1161 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 RRSKIKGV------DSKPNPQRTISHVKDSRAVPQNVKPGKVADMKDC-KEPDEDN-------VD 87
            |:::|..|      |.||..||.....|.::  .::::|.|..:.::. ||.|.|:       ::
  Rat     3 RKTEIYSVELNGTKDVKPADQRDDKKFKGAK--NKDLEPNKSHEKEELKKELDLDDHRLSNTELE 65

  Fly    88 QQNG-NIIQTGLTLTPEMLLSTSESSTHSASEVAGRLQVDVRTGLKWTEAKYRAKIIGHNELLLV 151
            |:.| |||| ||             |:..|:|:..|                    .|.|.|...
  Rat    66 QKYGTNIIQ-GL-------------SSVRATELLAR--------------------DGPNTLTPP 96

  Fly   152 AEDPTWKKYIEQFRNPL-ILLLLGSAL--VSVIMKQFDDAVSI------TIAILIVVTV---AFI 204
            .:.|...|:::|..... |||.:|:||  ::.:::..:::.|:      .|.:|:|:..   |:.
  Rat    97 KQTPEIIKFLKQMVGGFSILLWIGAALCWIAFVIQYVNNSASLDNVYLGAILVLVVILTGIFAYY 161

  Fly   205 QEYRSEKSLEELKKLVPPECHCLREGRLDTFLARELVPGDIVHLNVGDRVPADVRLFEAVDLSID 269
            ||.:|...:....|::|.:...:|:.......|.:||.||:|.:..||::|||:||..:....:|
  Rat   162 QEAKSTNIMASFSKMIPQQALVIRDAEKKVISAEQLVVGDVVEIKGGDQIPADIRLVFSQGCKVD 226

  Fly   270 ESSFTGETEPARKITDVLLNNTNVKDHSN---MKNIAFMGTLVRCGNGKGIVVSTGERSEFGEVF 331
            .||.|||:||..:.|:.        .|.|   .|||.|..|....|...|||::||:|:..|.:.
  Rat   227 NSSLTGESEPQARSTEF--------THENPLETKNIGFYSTTCLEGTATGIVINTGDRTIIGRIA 283

  Fly   332 KMMQAEEAPKTPLQKSMDILGAQLSFYSFLIIGVIMLLGWLQGKPLSEMFNIS------------ 384
            .:.....:.|||       :..::..:..::.||.:.:|.:        |.|:
  Rat   284 SLASGVGSEKTP-------IAIEIEHFVHIVAGVAVSIGII--------FFITAVCMKYYVLDAI 333

  Fly   385 ---VSLAVAAIPEGLPIVVTVTLALGVMRMAKRNSIVKKLPTVETLGCVNVICSDKTGTLTKNEM 446
               :|:.||.:||||...|||||:|...||||:|.:||.|..|||||..::||||||||||:|.|
  Rat   334 IFLISIIVANVPEGLLATVTVTLSLTAKRMAKKNCLVKNLEAVETLGSTSIICSDKTGTLTQNRM 398

  Fly   447 T-ATIIITSDGYMADVTGAGYNDQGEIHIRHCNNVEMAKTNITNLLEIGAVCNNAYIQNG----- 505
            | |.:...:..::|| |......|.         .:.:.....:|.:|..:||.|..:.|
  Rat   399 TVAHLWFDNQIFVAD-TSENQTKQA---------FDQSSGTWASLSKIITLCNRAEFRPGQESVP 453

  Fly   506 ----TLLGQPTEGALV---AVAMKNGMYATAENYVRIQEYPFSSEQKMMAVKCIHKYN--NNKEE 561
                |::|..:|.||:   .|.:.:.|.....|: ::.|.||:|..|...  .||:..  |:|..
  Rat   454 IMKRTVVGDASETALLKFSEVILGDVMGIRKRNH-KVAEIPFNSTNKFQL--SIHETEDPNDKRF 515

  Fly   562 IFFAKGALETLLPQCTKYQFGTQTVPLTKQNEAEFLAEAYEIGRKGLRVLA-----LAKGRSMQD 621
            :...|||.|.:|.:|:......|..||.|.:...|.....|:|..|.|||.     |...:..|.
  Rat   516 LVVMKGAPERILEKCSTIMINGQEQPLDKSSADSFHTAYMELGGLGERVLGFCHLYLPAEQFPQS 580

  Fly   622 LI------------YC--GLVGITDPPRPLVRESIEMLMQSGVRVKMVTGDAQETALAIDPSRRL 672
            .|            :|  ||:.:.||||..|.:::.....:|::|.|||||
  Rat   581 YIFDVDSVNFPTSNFCFVGLLSMIDPPRSTVPDAVSKCRSAGIKVIMVTGD-------------- 631

  Fly   673 QAVPTHAIPAWPTAGGVPLCSASACCSTNCLENAMKEIYLTALAQQGLPLVTANLIGIDTIHHQ- 736
                 |.|.|...|..|.:.||    :...:|:..|.                ..|.::.::.:
  Rat   632 -----HPITAKAIAKSVGIISA----NNETVEDIAKR----------------RNIAVEQVNKRE 671

  Fly   737 ----TLSGQEMDQMNEHQLDKVANNVS--VFYRVSPRHKLEIVKSLQRSGNIVGMTGDGVNDGVA 795
                .::|.|:..|...|||::..|..  ||.|.||:.||.||:..||...||.:|||||||..|
  Rat   672 AKAAVVTGMELKDMTPEQLDELLTNYQEIVFARTSPQQKLIIVEGCQRQDAIVAVTGDGVNDSPA 736

  Fly   796 LKKADIGIAMGKNGTDVCKEAADMILVNDDFHTIIAAIEEGKGIFYNIRNFVRFQLSTSIAALAL 860
            |||||||||||..|:|..|.||||:|::|:|.:|:..:|||:.||.|::..:.:.|:.:||.|..
  Rat   737 LKKADIGIAMGIAGSDAAKNAADMVLLDDNFASIVTGVEEGRLIFDNLKKTIAYTLTKNIAELCP 801

  Fly   861 IALATLMDIANPLNAMQILWINIIMDGPPAQSLGVEPVDHDVLKQKPRNVKQPMITKSVVVNVLL 925
            ..:..:..:..|:..:.||:|::..|..|:.:|..|..:.|::.:|||:.|     |..:||..|
  Rat   802 FLIYIVAGLPLPIGTITILFIDLGTDIIPSIALAYEKAESDIMNRKPRHKK-----KDRLVNTQL 861

  Fly   926 S------------------------------ASIIVLGTLWV-----------------FQREMA 943
            :                              .|:|.|...|.                 :||:..
  Rat   862 AIYSYLHIGLMQALGGFLVYFTVYAQQGFWPTSLINLRVAWETDDINDLEDSYGQEWTRYQRKYL 926

  Fly   944 DGTLGKTKRDTTMTFTCFVFFDMFNALSCRSQTKSVFTIGLTTNRMFLLAVAFSIIGQMLVVY-- 1006
            :.|      .:|..|...:...:.:.:..:::..|:|..||..|::..:.:|..:|..:::.|
  Rat   927 EWT------GSTAFFVAIMIQQIADLIIRKTRRNSIFQQGLFRNKVIWVGIASQVIVALILSYGL 985

  Fly  1007 --FPPLQMVFQTEALTPYDIFFLVSLTSSVL--VVSEIKKWFERT-----MERKMY 1053
              .|.|........      ::.|::..::|  |..|::|.|.|.     .::.||
  Rat   986 GSVPALSFTMLRVQ------YWFVAVPHAILIWVYDEMRKLFIRLYPGSWWDKNMY 1035

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPoCk	NP_001262220.1	ATPase-IIA2_Ca	110..1049	CDD:130585	287/1067 (27%)
		Cation_ATPase_N	112..179	CDD:279080	16/69 (23%)
		E1-E2_ATPase	191..425	CDD:278548	76/260 (29%)
		Cation_ATPase	496..579	CDD:289987	27/96 (28%)
		COG4087	<760..823	CDD:226572	40/62 (65%)
		Cation_ATPase_C	872..1044	CDD:279079	41/224 (18%)
Atp12a	NP_598201.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..50		11/48 (23%)
		ATPase-IIC_X-K	40..1036	CDD:273445	302/1122 (27%)
		Cation_ATPase_N	53..124	CDD:214842	25/104 (24%)
		E1-E2_ATPase	146..377	CDD:278548	76/253 (30%)
		Cation_ATPase	439..533	CDD:289987	27/96 (28%)
		HAD	<613..738	CDD:289480	45/163 (28%)
		Cation_ATPase_C	811..1021	CDD:279079	41/226 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334754
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.850