DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SPoCk and Atp13a1

DIOPT Version :9

Sequence 1:	NP_001262220.1	Gene:	SPoCk / 40495	FlyBaseID:	FBgn0052451	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	XP_006509627.1	Gene:	Atp13a1 / 170759	MGIID:	2180801	Length:	1223	Species:	Mus musculus

Alignment Length:	716	Identity:	168/716 - (23%)
Similarity:	283/716 - (39%)	Gaps:	193/716 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   192 TIAILIVVTVAFIQEYRSEKSLEELKKL--VPPECHCLREGRLDTFLARELVPGDIVHLNVGDR- 253
            |:::|:....:.:|:  ..:::.|::|:  .|......|..:.....:.::||||||.:....:
Mouse   266 TLSMLVAFEASLVQQ--QMRNMSEIRKMGNKPHMIQVYRSRKWRPVASDDIVPGDIVSIGRSPQE 328

  Fly   254 --VPADVRLFEAVDLSIDESSFTGETEPARK--ITD----------------VLLNNTNVKDH-- 296
              ||.||.|.....: :||:..|||:.|..|  |.|                |:...|.|..|
Mouse   329 NLVPCDVLLLRGRCI-VDEAMLTGESVPQMKEPIEDLSPDRVLDLQADARLHVIFGGTKVVQHIP 392

  Fly   297 -----SNMKNIAFMGTLVRCGNG-KGIVVSTGERSEFGEVFK--MMQAEEAPKTPLQKSMDILGA 353
                 |.:|.:         .|| ...|:.||..:..|.:.:  :...:......|:..:.||
Mouse   393 PQKATSGLKPV---------DNGCVAFVLRTGFNTSQGRLLRTILFGVKRVTANNLETFIFIL-- 446

  Fly   354 QLSFYSFLIIGVIMLLG--WLQG--KPLSEMFNISVS---LAVAAIPEGLPIVVTVTLALGVMRM 411
                  ||::..|....  |::|  .|....:.:.:.   :..:.:|..|||.:::.:...::.:
Mouse   447 ------FLLVFAIAAAAYVWVEGTKDPSRNRYKLFLECTLILTSVVPPELPIELSLAVNTSLIAL 505

  Fly   412 AKRNSIVKKLPTVETLGCVNVICSDKTGTLTKNEMTATIIITSDGYMADVTG-AGYNDQGEIHIR 475
            ||......:...:...|.|.|.|.|||||||.:.:.             |.| ||..|..|:
Mouse   506 AKLYMYCTEPFRIPFAGKVEVCCFDKTGTLTSDSLV-------------VRGVAGLRDGKEV--- 554

  Fly   476 HCNNVEMAKTNITNL-LEIG---AVCNN-AYIQNGTLLGQPTEGALVAVAMKNGMYATAENY--- 532
                     |.:::: :|..   |.|:: ..:.:|||:|.|.|.|::          ||.::
Mouse   555 ---------TPVSSIPIETHRALASCHSLMQLDDGTLVGDPLEKAML----------TAVDWTLT 600

  Fly   533 --------------VRI-QEYPFSSEQKMMAVKCIHKYNNNKEEIFFA--KGALETL---LPQCT 577
                          ::| |.:.|:|..|.|:|...::...:.:..:.|  |||.|||   ..||.
Mouse   601 KDEKVFPRSIKTQGLKIHQRFHFASALKRMSVLASYEKLGSTDLCYIAAVKGAPETLHSMFSQCP 665

  Fly   578 KYQFGTQTVPLTKQNEAEFLAEAYEIGRKGLRVLALA----------KGRSM-QDLIYCGL--VG 629
            .......|                ||.|:|.|||||.          :.|.: ::.:.|.|  ||
Mouse   666 PDYHHIHT----------------EISREGARVLALGYKELGHLTHQQAREIKREALECSLKFVG 714

  Fly   630 ITDPPRPLVRES---IEMLMQSGVRVKMVTGD--------AQETALAIDPSRRLQAVPTHAIPAW 683
            ......||..:|   |..:..:..||.|:|||        |||... ||.:..|...|
Mouse   715 FIVVSCPLKADSKAVIREIQNASHRVVMITGDNPLTACHVAQELHF-IDKAHTLILHP------- 771

  Fly   684 PTAGGVPLCSASACCSTNCLENAMKEIYLTALAQQGLPLVTANLIGIDTIHHQTLSGQ---EMDQ 745
            |:..|.|       |....:::::.           |||...:...:...|...|:|.   .:..
Mouse   772 PSEKGQP-------CEWRSIDSSIV-----------LPLTLGSPKALALEHALCLTGDGLAHLQA 818

  Fly   746 MNEHQLDKVANNVSVFYRVSPRHKLEIVKSLQRSGNIVGMTGDGVNDGVALKKADIGIAMGKNGT 810
            ::..||..:..:|.||.||:|:.|..::.||:..|.:..|.|||.||..|||.||:|:|:..|..
Mouse   819 VDPQQLLCLIPHVQVFARVAPKQKEFVITSLKELGYVTLMCGDGTNDVGALKHADVGVALLANAP 883

  Fly   811 D 811
            :
Mouse   884 E 884

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPoCk	NP_001262220.1	ATPase-IIA2_Ca	110..1049	CDD:130585	168/716 (23%)
		Cation_ATPase_N	112..179	CDD:279080
		E1-E2_ATPase	191..425	CDD:278548	54/272 (20%)
		Cation_ATPase	496..579	CDD:289987	26/106 (25%)
		COG4087	<760..823	CDD:226572	23/52 (44%)
		Cation_ATPase_C	872..1044	CDD:279079
Atp13a1	XP_006509627.1	P-type_ATPase_cation	211..1130	CDD:319843	168/716 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910