DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SPoCk and Atp4a

DIOPT Version :9

Sequence 1:	NP_001262220.1	Gene:	SPoCk / 40495	FlyBaseID:	FBgn0052451	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	NP_001277556.1	Gene:	Atp4a / 11944	MGIID:	88113	Length:	1034	Species:	Mus musculus

Alignment Length:	1068	Identity:	293/1068 - (27%)
Similarity:	474/1068 - (44%)	Gaps:	200/1068 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 EMLLSTSESSTH--SASEVAGRLQVDVRTGLKWTEAKYRAKII---GHNELLLVAEDPTWKKYIE 162
            |.:....|.:.|  |.||:..:.|.....|||   |...|:::   |.|.|......|.:.|:..
Mouse    43 ENMKKEMEINDHQLSVSELEQKYQTSATKGLK---ASLAAELLLRDGPNALRPPRGTPEYVKFAR 104

  Fly   163 QFRNPLILLLLGSALVSVIMKQF---------DDAVSITIAILIVVTV----AFIQEYRSEKSLE 214
            |....|..|:..:|.:.:|....         ||.:.:.:|::.||.|    .:.||::|...:.
Mouse   105 QLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAVALIAVVVVTGCFGYYQEFKSTNIIA 169

  Fly   215 ELKKLVPPECHCLREGRLDTFLARELVPGDIVHLNVGDRVPADVRLFEAVDLSIDESSFTGETEP 279
            ..|.|||.:...:|:|......|.:||.||:|.:..|||||||:|:..|....:|.||.|||:||
Mouse   170 SFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILSAQGCKVDNSSLTGESEP 234

  Fly   280 ARKITDVLLNNTNVKDHSN---MKNIAFMGTLVRCGNGKGIVVSTGERSEFGEVFKMMQAEEAPK 341
            ..:..:.        .|.:   .:||||..|:...|..:|:|||||:|:..|.:..:....|..|
Mouse   235 QTRSPEC--------THESPLETRNIAFFSTMCLEGTAQGLVVSTGDRTIIGRIASLASGVENEK 291

  Fly   342 TP----LQKSMDILGAQLSFYSFLIIGVIMLLGWLQGKPLSEMFNISVSLAVAAIPEGLPIVVTV 402
            ||    ::..:||:......:......|.|.:|:    .........:::.||.:||||...|||
Mouse   292 TPIAIEIEHFVDIIAGLAILFGATFFVVAMCIGY----TFLRAMVFFMAIVVAYVPEGLLATVTV 352

  Fly   403 TLALGVMRMAKRNSIVKKLPTVETLGCVNVICSDKTGTLTKNEMTAT-IIITSDGYMADVTGAGY 466
            .|:|...|:|.:|.:||.|..|||||..:|||||||||||:|.||.: :...:..:.||.|
Mouse   353 CLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTT---- 413

  Fly   467 NDQGEIHIRHCNNVEMAKTNITNLLEIGAVCNNAYIQNG---------TLLGQPTEGALV---AV 519
            .||..      ...:.:......|..:..:||.|..::|         .::|..:|.||:   .:
Mouse   414 EDQSG------QTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSEL 472

  Fly   520 AMKNGMYATAENYVRIQEYPFSSEQKMMAVKCIHKYNNNKE--EIFFAKGALETLLPQCTKYQFG 582
            .:.|.| ...:.:.::.|.||:|..|...  .||...:.::  .:...|||.|.:|.:|:.....
Mouse   473 TLGNAM-GYRDRFPKVCEIPFNSINKFQL--SIHTLEDPRDSRHLLVMKGAPERVLERCSSILIK 534

  Fly   583 TQTVPLTKQNEAEFLAEAYEIGRKGLRVLAL-------------------AKGRSMQDLIYCGLV 628
            .|.:||.:|....|......:|..|.|||..                   |.......|.:.|||
Mouse   535 GQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLV 599

  Fly   629 GITDPPRPLVRESIEMLMQSGVRVKMVTGDAQETALAIDPSRRLQAVPTHAIPAWPTAGGVPLCS 693
            .:.||||..|.:::.....:|:||.|||||                   |.|.|...|..|.:.|
Mouse   600 SMIDPPRATVPDAVLKCRTAGIRVIMVTGD-------------------HPITAKAIAASVGIIS 645

  Fly   694 ASACCSTNCLENAMKEIYLTALAQQGLPLVTANLIGIDTIHHQ-----TLSGQEMDQMNEHQLDK 753
            ..:        ..:::|    .|:..:|        :|.::.:     .::|.::..|:..:|.:
Mouse   646 EGS--------ETVEDI----AARLRMP--------VDQVNRKDARACVINGMQLKDMDPSELVE 690

  Fly   754 V--ANNVSVFYRVSPRHKLEIVKSLQRSGNIVGMTGDGVNDGVALKKADIGIAMGKNGTDVCKEA 816
            .  .:...||.|.||:.||.||:|.||.|.||.:|||||||..||||||||:|||..|:|..|.|
Mouse   691 ALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNA 755

  Fly   817 ADMILVNDDFHTIIAAIEEGKGIFYNIRNFVRFQLSTSIAALALIALATLMDIANPLNAMQILWI 881
            |||||::|:|.:|:..:|:|:.||.|::..:.:.|:.:|..|....:...:.:..||..:.||:|
Mouse   756 ADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFI 820

  Fly   882 NIIMDGPPAQSLGVEPVDHDVLKQKPRNVKQPMITKSVVVNVLLSA-SIIVLGTLWVFQ------ 939
            .:..|..|:.||..|..:.|::..:|||.|:..:     ||..|:| |...:|.:..|.
Mouse   821 ELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRL-----VNEPLAAYSYFQIGAIQSFAGFADYF 880

  Fly   940 -------------------------REMADG-----TLGKTKRDTTMTFTCF-VFF------DMF 967
                                     :::.|.     |.|:.   ....:||: |||      .:.
Mouse   881 TAMAQEGWFPLLCVGLRPQWEDHHLQDLQDSYGQEWTFGQR---LYQQYTCYTVFFISIEMCQIA 942

  Fly   968 NALSCRSQTKSVFTIGLTTNRMFLLAVAFSIIGQMLVVYFPPLQMVFQTEALTPYDI-FFLVSLT 1031
            :.|..:::..|||..|...|::.::|:.|.:.....:.|.|.:..:|.   ..|... ::||.:.
Mouse   943 DVLIRKTRRLSVFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFN---FMPIRFQWWLVPMP 1004

  Fly  1032 SSVL--VVSEIKK---------WFERTM 1048
            ..:|  |..||:|         |:::.:
Mouse  1005 FGLLIFVYDEIRKLGVRCCPGSWWDQEL 1032

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPoCk	NP_001262220.1	ATPase-IIA2_Ca	110..1049	CDD:130585	292/1061 (28%)
		Cation_ATPase_N	112..179	CDD:279080	19/71 (27%)
		E1-E2_ATPase	191..425	CDD:278548	77/244 (32%)
		Cation_ATPase	496..579	CDD:289987	23/96 (24%)
		COG4087	<760..823	CDD:226572	42/62 (68%)
		Cation_ATPase_C	872..1044	CDD:279079	49/227 (22%)
Atp4a	NP_001277556.1	H-K_ATPase_N	2..>27	CDD:286172
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	14..40
		ATPase-IIC_X-K	42..1034	CDD:273445	293/1068 (27%)
		Cation_ATPase_N	50..124	CDD:214842	20/76 (26%)
		E1-E2_ATPase	156..375	CDD:278548	73/230 (32%)
		Cation_ATPase	437..531	CDD:289987	23/96 (24%)
		COG4087	616..>742	CDD:226572	50/164 (30%)
		Cation_ATPase_C	809..1018	CDD:279079	48/219 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831050
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.850