Protein Alignment SPoCk and Atp2b2

DIOPT Version :9

• Sequence 1: NP_001262220.1
• Gene: SPoCk / 40495
• FlyBaseID: FBgn0052451
• Length: 1062
• Species: Drosophila melanogaster
• Sequence 2: XP_030110982.1
• Gene: Atp2b2 / 11941
• MGIID: 105368
• Length: 1272
• Species: Mus musculus
• Alignment Length: 1164
• Identity: 294/1164 - (25%)
• Similarity: 478/1164 - (41%)
• Gaps: 329/1164 - (28%)

  Fly    75 MKDCKEPDEDNVDQQNGNIIQTGLTLTPEMLLSTSE----------SSTHSASE-VAGRLQVDVR 128
            |.|....|..:.:|:|.:........|.|.|.|..|          ..|:..:| :..||:....
Mouse     1 MGDMTNSDFYSKNQRNESSHGGEFGCTMEELRSLMELRGTEAVVKIKETYGDTEAICRRLKTSPV 65

  Fly   129 TGLKWT--EAKYRAKIIGHNELLLVAEDP-TWKKYI-EQFRNPLILLLLGSALVSVIMKQFD--- 186
            .||..|  :.:.|.:|.|.|  .:..:.| |:.:.: |..::..:::|..:|::|:.:..:.
Mouse    66 EGLPGTAPDLEKRKQIFGQN--FIPPKKPKTFLQLVWEALQDVTLIILEIAAIISLGLSFYHPPG 128

  Fly   187 ------------------------DAVSITIAILIVVTVAFIQEYRSEKSLEELKKLVPPE--CH 225
                                    :..:|.::::.||.|....::..||....|:..:..|  ..
Mouse   129 ESNEGCATAQGGAEDEGEAEAGWIEGAAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQEQKFT 193

  Fly   226 CLREGRLDTFLARELVPGDIVHLNVGDRVPADVRLFEAVDLSIDESSFTGETEPARKITD---VL 287
            .:|.|::......|:|.|||..:..||.:|||....:..||.|||||.|||::..||..|   :|
Mouse   194 VVRAGQVVQIPVAEIVVGDIAQIKYGDLLPADGLFIQGNDLKIDESSLTGESDQVRKSVDKDPML 258

  Fly   288 LNNTNVKDHSNMKNIAFMGTLVRCGNGKGIVVSTGERSEFGEVFKMMQA----EE---------- 338
            |:.|:|.:                |:|:.:|.:.|..|:.|.:|.::.|    ||
Mouse   259 LSGTHVME----------------GSGRMVVTAVGVNSQTGIIFTLLGAGGEEEEKKDKKGVKKG 307

  Fly   339 -----------AP---------------------------------------------------- 340
                       ||
Mouse   308 DGLQIPAADGAAPANAAGSANASLVNGKMQDGSADSSQSKAKQQDGAAAMEMQPLKSAEGGDADD 372

  Fly   341 ----------KTPLQKSMDILGAQLSFYSFLI--IGVIMLLGW-------LQGKP-LSE------ 379
                      |:.||..:..|..|:.....::  |.||:|:.:       :..|| |:|
Mouse   373 KKKANMHKKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFTVDTFVVNKKPWLTECTPVYV 437

  Fly   380 -----MFNISVSLAVAAIPEGLPIVVTVTLALGVMRMAKRNSIVKKLPTVETLGCVNVICSDKTG 439
                 .|.|.|::.|.|:|||||:.||::||..|.:|.|.|::|:.|...||:|....|||||||
Mouse   438 QYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTG 502

  Fly   440 TLTKNEMTATIIITSDGYMADVTGAGYNDQGEIHIRHCNNVEMAKTNITNLLEIGAVCNNAYI-- 502
            |||.|.||..     ..|:.||......|...|:         |||  ..||......|:||.
Mouse   503 TLTTNRMTVV-----QAYVGDVHYKEIPDPSSIN---------AKT--LELLVNAIAINSAYTTK 551

  Fly   503 -----QNGTL---LGQPTEGALVAVAMKNGMYATAENY--VRIQ--------EYPFSSEQKMMA- 548
                 :.|.|   :|..||..|:...:.     ..::|  ||.|        .|.|:|.:|.|:
Mouse   552 ILPPEKEGALPRQVGNKTECGLLGFVLD-----LRQDYEPVRSQMPEEKLYKVYTFNSVRKSMST 611

  Fly   549 -VKCIHKYNNNKEEIF--FAKGALETLLPQCTKYQFGTQTVPLTK-QNEAEFLAEAYE-IGRKGL 608
             :|.       .:|.|  ::|||.|.:|.:|.|...|.....:.: ::..|.:.:..| :...||
Mouse   612 VIKM-------PDESFRMYSKGASEIVLKKCCKILSGAGEARVFRPRDRDEMVKKVIEPMACDGL 669

  Fly   609 RVLALA--------------KGRSMQDLIYCGLVGITDPPRPLVRESIEMLMQSGVRVKMVTGDA 659
            |.:.:|              :...:.:|....:|||.||.||.|.|:|....::|:.|:|||||.
Mouse   670 RTICVAYRDFPSSPEPDWDNENDILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDN 734

  Fly   660 QETALAIDPSRRLQAVPTHAIPAWPTAGGVPLCSASACCSTN------CLENAMKEIYLTALAQQ 718
            ..||.||                           |..|...:      |||.  ||.......::
Mouse   735 INTARAI---------------------------AIKCGIIHPGEDFLCLEG--KEFNRRIRNEK 770

  Fly   719 GLPLVTANLIGIDTIHHQTLSGQEMDQMNEHQLDKVANNVSVFYRVSPRHKLEIVKSL------- 776
            |                         ::.:.::||:...:.|..|.||..|..:||.:
Mouse   771 G-------------------------EIEQERIDKIWPKLRVLARSSPTDKHTLVKGIIDSTHTE 810

  Fly   777 QRSGNIVGMTGDGVNDGVALKKADIGIAMGKNGTDVCKEAADMILVNDDFHTIIAAIEEGKGIFY 841
            ||  .:|.:||||.|||.||||||:|.|||..||||.|||:|:||.:|:|.:|:.|:..|:.::.
Mouse   811 QR--QVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYD 873

  Fly   842 NIRNFVRFQLSTSIAALALIALATLMDIANPLNAMQILWINIIMDGPPAQSLGVEPVDHDVLKQK 906
            :|..|::|||:.::.|:.:......:...:||.|:|:||:|:|||...:.:|..||....:|.:|
Mouse   874 SISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTETLLLRK 938

  Fly   907 PRNVKQPMITKSVVVNVLLSA--SIIVLGTLWVFQREMADGTLGKT-------KRDTTMTFTCFV 962
            |....:|:|:::::.|:|..|  .:.::.||.....:|.....|:.       ....|:.|..||
Mouse   939 PYGRNKPLISRTMMKNILGHAVYQLTLIFTLLFVGEKMFQIDSGRNAPLHSPPSEHYTIIFNTFV 1003

  Fly   963 FFDMFNALSCRS--QTKSVFTIGLTTNRMFLLAVAFSIIGQMLVVYF-------PPLQM 1012
            ...:||.::.|.  ..::||. |:..|.:|...|..:...|:::|.|       .|||:
Mouse  1004 MMQLFNEINARKIHGERNVFD-GIFRNPIFCTIVLGTFAIQIVIVQFGGKPFSCSPLQL 1061

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SPoCk	NP_001262220.1	ATPase-IIA2_Ca	110..1049	CDD:130585	285/1129 (25%)
		Cation_ATPase_N	112..179	CDD:279080	16/71 (23%)
		E1-E2_ATPase	191..425	CDD:278548	82/346 (24%)
		Cation_ATPase	496..579	CDD:289987	27/106 (25%)
		COG4087	<760..823	CDD:226572	37/69 (54%)
		Cation_ATPase_C	872..1044	CDD:279079	44/159 (28%)
Atp2b2	XP_030110982.1	ATPase-IIB_Ca	12..1087	CDD:273668	291/1153 (25%)
		ATP_Ca_trans_C	1126..1201	CDD:372101

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831030
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.940