DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SPoCk and Atp2a2

DIOPT Version :9

Sequence 1:	NP_001262220.1	Gene:	SPoCk / 40495	FlyBaseID:	FBgn0052451	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	NP_001103610.1	Gene:	Atp2a2 / 11938	MGIID:	88110	Length:	1044	Species:	Mus musculus

Alignment Length:	1058	Identity:	329/1058 - (31%)
Similarity:	515/1058 - (48%)	Gaps:	199/1058 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 THSASEVAGRLQVDVRTGLKWTEAKYRAKIIGHNELLLVAEDPTWKKYIEQFRNPLILLLLGSAL 177
            |.:..||.|...|:..|||...:.|...:..|.|||.........:..||||.:.|:.:||.:|.
Mouse     6 TKTVEEVLGHFGVNESTGLSLEQVKKLKERWGSNELPAEEGKTLLELVIEQFEDLLVRILLLAAC 70

  Fly   178 VSVIMKQFDDA-------VSITIAILIVVTVAFI---QEYRSEKSLEELKKLVPPECHCLREGR- 231
            :|.::..|::.       |...:.:||:|..|.:   ||..:|.::|.||:..|......|:.|
Mouse    71 ISFVLAWFEEGEETITAFVEPFVILLILVANAIVGVWQERNAENAIEALKEYEPEMGKVYRQDRK 135

  Fly   232 -LDTFLARELVPGDIVHLNVGDRVPADVRL--FEAVDLSIDESSFTGETEPARKITDVLLNNTNV 293
             :....|:::||||||.:.|||:||||:||  .::..|.:|:|..|||:....|.||.:.:...|
Mouse   136 SVQRIKAKDIVPGDIVEIAVGDKVPADIRLTSIKSTTLRVDQSILTGESVSVIKHTDPVPDPRAV 200

  Fly   294 KDHSNMKNIAFMGTLVRCGNGKGIVVSTGERSEFGEVFKMMQAEEAPKTPLQKSMDILGAQLS-F 357
              :.:.||:.|.||.:..|...|:||:||..:|.|::...|.|.|..:||||:.:|..|.||| .
Mouse   201 --NQDKKNMLFSGTNIAAGKAMGVVVATGVNTEIGKIRDEMVATEQERTPLQQKLDEFGEQLSKV 263

  Fly   358 YSFLIIGV-IMLLG----------WLQGKPLSEMFNISVSLAVAAIPEGLPIVVTVTLALGVMRM 411
            .|.:.|.| |:.:|          |::|  ....|.|:|:|||||||||||.|:|..||||..||
Mouse   264 ISLICIAVWIINIGHFNDPVHGGSWIRG--AIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRM 326

  Fly   412 AKRNSIVKKLPTVETLGCVNVICSDKTGTLTKNEMTATIIITSDGYMAD--------VTGAGYND 468
            ||:|:||:.||:||||||.:|||||||||||.|:|:...:...|....|        :||:.|..
Mouse   327 AKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFILDKVEGDTCSLNEFSITGSTYAP 391

  Fly   469 QGEIH-----IRHCNNVEMAKTNITNLLEIGAVCNNAYIQNGTL------LGQPTEGALVAVAMK 522
            .||:.     :: |:..:    .:..|..|.|:||::.:.....      :|:.||.||..:..|
Mouse   392 IGEVQKDDKPVK-CHQYD----GLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVEK 451

  Fly   523 NGMY------------ATAENYVRIQ----EY--PFSSEQKMMAVKCI-HKYNNNKEEIFFAKGA 568
            ..::            |.|.|.|..|    |:  .||.::|.|:|.|. :|.:.......|.|||
Mouse   452 MNVFDTELKGLSKIERANACNSVIKQLMKKEFTLEFSRDRKSMSVYCTPNKPSRTSMSKMFVKGA 516

  Fly   569 LETLLPQCTKYQFGTQTVPLT---KQNEAEFLAEAYEIGRKGLRVLALA------KGRSMQ---- 620
            .|.::.:||..:.|:..||:|   ||.....:.| :..|...||.||||      |...|.
Mouse   517 PEGVIDRCTHIRVGSTKVPMTPGVKQKIMSVIRE-WGSGSDTLRCLALATHDNPLKREEMHLEDS 580

  Fly   621 --------DLIYCGLVGITDPPRPLVRESIEMLMQSGVRVKMVTGDAQETALAIDPSRRLQAVPT 677
                    :|.:.|.||:.||||..|..|:::..|:|:||.|:|||.:.||:||  .||
Mouse   581 ANFIKYETNLTFVGCVGMLDPPRIEVASSVKLCRQAGIRVIMITGDNKGTAVAI--CRR------ 637

  Fly   678 HAIPAWPTAGGVPLCSASACCSTNCLENAMKEIYLTALAQQGLPLVTANLIGI----DTIHHQTL 738
                                                              |||    :.:..:..
Mouse   638 --------------------------------------------------IGIFGQDEDVTSKAF 652

  Fly   739 SGQEMDQMNEHQLDKVANNVSVFYRVSPRHKLEIVKSLQRSGNIVGMTGDGVNDGVALKKADIGI 803
            :|:|.|:::.........|...|.||.|.||.:||:.||....|..||||||||..||||::|||
Mouse   653 TGREFDELSPSAQRDACLNARCFARVEPSHKSKIVEFLQSFDEITAMTGDGVNDAPALKKSEIGI 717

  Fly   804 AMGKNGTDVCKEAADMILVNDDFHTIIAAIEEGKGIFYNIRNFVRFQLSTSIAALALIALATLMD 868
            ||| :||.|.|.|::|:|.:|:|.||:||:|||:.|:.|::.|:|:.:|:::..:..|.|...:.
Mouse   718 AMG-SGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALG 781

  Fly   869 IANPLNAMQILWINIIMDGPPAQSLGVEPVDHDVLKQKPRNVKQPMIT-----KSVVVNVLLSAS 928
            ....|..:|:||:|::.||.||.:||..|.|.|::.:.|||.|:|:|:     :.:.:...:.|:
Mouse   782 FPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMNKPPRNPKEPLISGWLFFRYLAIGCYVGAA 846

  Fly   929 IIVLGTLWVFQREMADG---------------------------TLGKTKRDTTMTFTCFVFFDM 966
            .:.....|..   .|||                           .:.::....||..:..|..:|
Mouse   847 TVGAAAWWFI---AADGGPRVSFYQLSHFLQCKEDNPDFDGVDCAIFESPYPMTMALSVLVTIEM 908

  Fly   967 FNALSCRSQTKSVFTIGLTTNRMFLLAVAFSIIGQMLVVYFPPLQMVFQTEALTPYDI---FFLV 1028
            .|||:..|:.:|:..:....|...:.::..|:....|::|..||.::||   :||.::   ..::
Mouse   909 CNALNSLSENQSLLRMPPWENIWLVGSICLSMSLHFLILYVEPLPLIFQ---ITPLNLTQWLMVL 970

  Fly  1029 SLTSSVLVVSEIKKWFER 1046
            .::..|:::.|..|:..|
Mouse   971 KISLPVILMDETLKFVAR 988

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPoCk	NP_001262220.1	ATPase-IIA2_Ca	110..1049	CDD:130585	329/1058 (31%)
		Cation_ATPase_N	112..179	CDD:279080	21/65 (32%)
		E1-E2_ATPase	191..425	CDD:278548	100/252 (40%)
		Cation_ATPase	496..579	CDD:289987	28/107 (26%)
		COG4087	<760..823	CDD:226572	36/62 (58%)
		Cation_ATPase_C	872..1044	CDD:279079	47/206 (23%)
Atp2a2	NP_001103610.1	Cation_ATPase_N	4..72	CDD:279080	21/65 (32%)
		ATPase-IIA1_Ca	53..988	CDD:273452	315/1009 (31%)
		E1-E2_ATPase	93..340	CDD:278548	100/250 (40%)
		Cation_ATPase	419..527	CDD:289987	28/107 (26%)
		Interaction with HAX1. /evidence=ECO:0000250	575..594		2/18 (11%)
		HAD	<605..711	CDD:289480	43/163 (26%)
		Cation_ATPase_C	783..986	CDD:279079	47/208 (23%)
		Interaction with PLN. /evidence=ECO:0000250\|UniProtKB:P04191	787..807		8/19 (42%)
		Interaction with TMEM64 and PDIA3. /evidence=ECO:0000269\|PubMed:23395171	788..1044		47/207 (23%)
		Interaction with PLN. /evidence=ECO:0000250\|UniProtKB:P04191	931..942		1/10 (10%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831049
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0202
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	1	1.010	-	-		D100699at2759
OrthoFinder	1	1.000	-	-		FOG0000231
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100158
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.660