DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SPoCk and Atp2a1

DIOPT Version :9

Sequence 1:	NP_001262220.1	Gene:	SPoCk / 40495	FlyBaseID:	FBgn0052451	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	NP_031530.2	Gene:	Atp2a1 / 11937	MGIID:	105058	Length:	994	Species:	Mus musculus

Alignment Length:	1052	Identity:	330/1052 - (31%)
Similarity:	510/1052 - (48%)	Gaps:	182/1052 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 STHSAS--EVAGRLQVDVRTGLKWTEAKYRAKIIGHNELLLVAEDPTWKKYIEQFRNPLILLLLG 174
            :.||.|  |......|...|||...:.|...:..|.|||........|:..:|||.:.|:.:||.
Mouse     3 AAHSKSTEECLSYFGVSETTGLTPDQVKRHLEKYGPNELPAEEGKSLWELVVEQFEDLLVRILLL 67

  Fly   175 SALVSVIMKQFDDA-------VSITIAILIVVTVAFI---QEYRSEKSLEELKKLVPPECHCLRE 229
            :|.:|.::..|::.       |...:.:||::..|.:   ||..:|.::|.||:..|......|.
Mouse    68 AACISFVLAWFEEGEETVTAFVEPFVILLILIANAIVGVWQERNAENAIEALKEYEPEMGKVYRA 132

  Fly   230 GR--LDTFLARELVPGDIVHLNVGDRVPADVRL--FEAVDLSIDESSFTGETEPARKITDVLLNN 290
            .|  :....||::||||||.:.|||:||||:|:  .::..|.:|:|..|||:....|.||.:.:.
Mouse   133 DRKSVQRIKARDIVPGDIVEVAVGDKVPADIRILSIKSTTLRVDQSILTGESVSVIKHTDPVPDP 197

  Fly   291 TNVKDHSNMKNIAFMGTLVRCGNGKGIVVSTGERSEFGEVFKMMQAEEAPKTPLQKSMDILGAQL 355
            ..|  :.:.||:.|.||.:..|...|||.:||..:|.|::...|.|.|..|||||:.:|..|.||
Mouse   198 RAV--NQDKKNMLFSGTNIAAGKAVGIVATTGVSTEIGKIRDQMAATEQDKTPLQQKLDEFGEQL 260

  Fly   356 SFYSFLIIGVIMLL------------GWLQGKPLSEMFNISVSLAVAAIPEGLPIVVTVTLALGV 408
            |....||...:.|:            .|.:|  ....|.|:|:|||||||||||.|:|..||||.
Mouse   261 SKVISLICVAVWLINIGHFNDPVHGGSWFRG--AIYYFKIAVALAVAAIPEGLPAVITTCLALGT 323

  Fly   409 MRMAKRNSIVKKLPTVETLGCVNVICSDKTGTLTKNEMTAT---IIITSDGYMA-----DVTGAG 465
            .||||:|:||:.||:||||||.:|||||||||||.|:|:..   ||...||.:.     .:||:.
Mouse   324 RRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCKMFIIDKVDGDVCSLNEFSITGST 388

  Fly   466 YNDQGEIHIRHCNNVEMAK-TNITNLLEIGAVCNNAYIQ-NGT-----LLGQPTEGALVAVAMKN 523
            |..:||: :::...|...: ..:..|..|.|:||::.:. |.|     .:|:.||.||..:..|.
Mouse   389 YAPEGEV-LKNDKPVRAGQYDGLVELATICALCNDSSLDFNETKGVYEKVGEATETALTTLVEKM 452

  Fly   524 GMY------------ATAENYVRIQ----EY--PFSSEQKMMAVKCIHKYNN-----NKEEIFFA 565
            .::            |.|.|.|..|    |:  .||.::|.|:|.|....::     ||   .|.
Mouse   453 NVFNTEVRSLSKVERANACNSVIRQLMKKEFTLEFSRDRKSMSVYCSPAKSSRAAVGNK---MFV 514

  Fly   566 KGALETLLPQCTKYQFGTQTVPLTKQNEAEFLA--EAYEIGRKGLRVLALA------KGRSM--- 619
            |||.|.::.:|...:.||..||||...:.:.::  :.:..||..||.||||      |...|
Mouse   515 KGAPEGVIDRCNYVRVGTTRVPLTGPVKEKIMSVIKEWGTGRDTLRCLALATRDTPPKREEMVLD 579

  Fly   620 ---------QDLIYCGLVGITDPPRPLVRESIEMLMQSGVRVKMVTGDAQETALAIDPSRRLQAV 675
                     .||.:.|:||:.||||..|..||::...:|:||.|:|||.:.||:||
Mouse   580 DSAKFMEYEMDLTFVGVVGMLDPPRKEVTGSIQLCRDAGIRVIMITGDNKGTAIAI--------- 635

  Fly   676 PTHAIPAWPTAGGVPLCSASACCSTNCLENAMKEIYLTALAQQGLPLVTANLIGIDTIHHQTLSG 740
                            |......|.|                             :.:..:..:|
Mouse   636 ----------------CRRIGIFSEN-----------------------------EEVTDRAYTG 655

  Fly   741 QEMDQMNEHQLDKVANNVSVFYRVSPRHKLEIVKSLQRSGNIVGMTGDGVNDGVALKKADIGIAM 805
            :|.|.:...:..:.......|.||.|.||.:||:.||....|..||||||||..|||||:|||||
Mouse   656 REFDDLPLAEQREACRRACCFARVEPSHKSKIVEYLQSYDEITAMTGDGVNDAPALKKAEIGIAM 720

  Fly   806 GKNGTDVCKEAADMILVNDDFHTIIAAIEEGKGIFYNIRNFVRFQLSTSIAALALIALATLMDIA 870
            | :||.|.|.|::|:|.:|:|.||:||:|||:.|:.|::.|:|:.:|:::..:..|.|...:.:.
Mouse   721 G-SGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGLP 784

  Fly   871 NPLNAMQILWINIIMDGPPAQSLGVEPVDHDVLKQKPRNVKQPMIT-----KSVVVNVLLSASII 930
            ..|..:|:||:|::.||.||.:||..|.|.|::.:.||:.|:|:|:     :.:.:...:.|:.:
Mouse   785 EALIPVQLLWVNLVTDGLPATALGFNPPDLDIMDRPPRSPKEPLISGWLFFRYMAIGGYVGAATV 849

  Fly   931 VLGTLWVFQREMADG--------------------------TLGKTKRDTTMTFTCFVFFDMFNA 969
            .....|....|  ||                          .:.:.....||..:..|..:|.||
Mouse   850 GAAAWWFLYAE--DGPHVSYHQLTHFMQCTEHNPEFDGLDCEVFEAPEPMTMALSVLVTIEMCNA 912

  Fly   970 LSCRSQTKSVFTIGLTTNRMFLLAVAFSIIGQMLVVYFPPLQMVFQTEALTPYDIFFLVSLTSSV 1034
            |:..|:.:|:..:....|...|.::..|:....|::|..||.|:|:..||.......::.::..|
Mouse   913 LNSLSENQSLLRMPPWVNIWLLGSICLSMSLHFLILYVDPLPMIFKLRALDFTQWLMVLKISLPV 977

  Fly  1035 LVVSEIKKWFER 1046
            :.:.|:.|:..|
Mouse   978 IGLDELLKFIAR 989

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPoCk	NP_001262220.1	ATPase-IIA2_Ca	110..1049	CDD:130585	330/1052 (31%)
		Cation_ATPase_N	112..179	CDD:279080	21/68 (31%)
		E1-E2_ATPase	191..425	CDD:278548	98/252 (39%)
		Cation_ATPase	496..579	CDD:289987	30/111 (27%)
		COG4087	<760..823	CDD:226572	37/62 (60%)
		Cation_ATPase_C	872..1044	CDD:279079	47/202 (23%)
Atp2a1	NP_031530.2	P-type_ATPase_SERCA	5..989	CDD:319778	329/1048 (31%)
		Interaction with PLN. /evidence=ECO:0000250\|UniProtKB:P04191	788..808		8/19 (42%)
		Interaction with PLN. /evidence=ECO:0000250\|UniProtKB:P04191	932..943		2/10 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831053
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0202
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	1	1.010	-	-		D100699at2759
OrthoFinder	1	1.000	-	-		FOG0000231
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100158
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.660