DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SPoCk and Atp1a1

DIOPT Version :9

Sequence 1:	NP_001262220.1	Gene:	SPoCk / 40495	FlyBaseID:	FBgn0052451	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	NP_659149.1	Gene:	Atp1a1 / 11928	MGIID:	88105	Length:	1023	Species:	Mus musculus

Alignment Length:	1114	Identity:	311/1114 - (27%)
Similarity:	483/1114 - (43%)	Gaps:	206/1114 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 KGVDSKPNPQRTISHVKDSRAVPQNVKPGKVADMKDCKEPDEDNVDQQNGNIIQTGLTLTPEMLL 106
            |||.........:|...|        |.||.|.    ||.|.|.:.::        :::....|
Mouse     3 KGVGRDKYEPAAVSEHGD--------KKGKKAK----KERDMDELKKE--------VSMDDHKL- 46

  Fly   107 STSESSTHSASEVAGRLQVDVRTGLKWTEAKYRAKII---GHNELLLVAEDPTWKKYIEQFRNPL 168
                    |..|:..:...|:..||  |.|: .|:|:   |.|.|......|.|.|:..|.....
Mouse    47 --------SLDELHRKYGTDLSRGL--TPAR-AAEILARDGPNALTPPPTTPEWVKFCRQLFGGF 100

  Fly   169 ILLLLGSALVSVIMKQFDDA-----------VSITIAILIVVT--VAFIQEYRSEKSLEELKKLV 220
            .:||...|::..:......|           :.:.::.::::|  .::.||.:|.|.:|..|.:|
Mouse   101 SMLLWIGAILCFLAYGIRSATEEEPPNDDLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMV 165

  Fly   221 PPECHCLREGRLDTFLARELVPGDIVHLNVGDRVPADVRLFEAVDLSIDESSFTGETEPARKITD 285
            |.:...:|.|...:..|.::|.||:|.:..|||:|||:|:..|....:|.||.|||:||..:..|
Mouse   166 PQQALVIRNGEKMSINAEDVVVGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEPQTRSPD 230

  Fly   286 VLLNNTNVKDHSNMKNIAFMGTLVRCGNGKGIVVSTGERSEFGEVFKMMQAEEAPKTPLQKSMD- 349
              ..|.|..:   .:||||..|....|..:||||.||:|:..|.:..:....|..:||:.:.::
Mouse   231 --FTNENPLE---TRNIAFFSTNCVEGTARGIVVYTGDRTVMGRIATLASGLEGGQTPIAEEIEH 290

  Fly   350 ----ILGAQLSF-YSFLIIGVIMLLGWLQGKPLSEMFNISVSLAVAAIPEGLPIVVTVTLALGVM 409
                |.|..:.. .||.|:.:|:...||      |.....:.:.||.:||||...|||.|.|...
Mouse   291 FIHLITGVAVFLGVSFFILSLILEYTWL------EAVIFLIGIIVANVPEGLLATVTVCLTLTAK 349

  Fly   410 RMAKRNSIVKKLPTVETLGCVNVICSDKTGTLTKNEMT-ATIIITSDGYMADVTGAGYNDQGEIH 473
            |||::|.:||.|..|||||..:.||||||||||:|.|| |.:...:..:.||.|   .|..|
Mouse   350 RMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTT---ENQSG--- 408

  Fly   474 IRHCNNVEMAKTNIT--NLLEIGAVCNNAYIQ---------NGTLLGQPTEGAL---VAVAMKNG 524
                  |...||:.|  .|..|..:||.|..|         ...:.|..:|.||   :.|...:.
Mouse   409 ------VSFDKTSATWFALSRIAGLCNRAVFQANQENLPILKRAVAGDASESALLKCIEVCCGSV 467

  Fly   525 MYATAENYVRIQEYPFSSEQKMMAVKCIHKYNNNKE--EIFFAKGALETLLPQCTKYQFGTQTVP 587
            | ...|.|.:|.|.||:|..|...  .|||..|..|  .:...|||.|.:|.:|:......:..|
Mouse   468 M-EMREKYSKIVEIPFNSTNKYQL--SIHKNPNASEPKHLLVMKGAPERILDRCSSILLHGKEQP 529

  Fly   588 LTKQNEAEFLAEAYEIGRKGLRVLALAK-------------------GRSMQDLIYCGLVGITDP 633
            |.::.:..|.....|:|..|.|||....                   ...:.:|.:.||:.:.||
Mouse   530 LDEELKDAFQNAYLELGGLGERVLGFCHLLLPDEQFPEGFQFDTDDVNFPVDNLCFVGLISMIDP 594

  Fly   634 PRPLVRESIEMLMQSGVRVKMVTGDAQETALAIDPSRRLQAVPTHAIPAWPTAGGVPLCSASACC 698
            ||..|.:::.....:|::|.|||||                   |.|.|...|.||.:.|..
Mouse   595 PRAAVPDAVGKCRSAGIKVIMVTGD-------------------HPITAKAIAKGVGIISEG--- 637

  Fly   699 STNCLENAMKEIYLTALAQQGLPLVTANLIGIDTIHHQTLSGQEMDQMNEHQLDKVA--NNVSVF 761
                 ...:::|    .|:..:|:   |.:.........:.|.::..|...:||.:.  :...||
Mouse   638 -----NETVEDI----AARLNIPV---NQVNPRDAKACVVHGSDLKDMTSEELDDILRYHTEIVF 690

  Fly   762 YRVSPRHKLEIVKSLQRSGNIVGMTGDGVNDGVALKKADIGIAMGKNGTDVCKEAADMILVNDDF 826
            .|.||:.||.||:..||.|.||.:|||||||..||||||||:|||..|:||.|:||||||::|:|
Mouse   691 ARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIVGSDVSKQAADMILLDDNF 755

  Fly   827 HTIIAAIEEGKGIFYNIRNFVRFQLSTSIAALALIALATLMDIANPLNAMQILWINIIMDGPPAQ 891
            .:|:..:|||:.||.|::..:.:.|:::|..:....:..:.:|..||..:.||.|::..|..||.
Mouse   756 ASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLIFIIANIPLPLGTVTILCIDLGTDMVPAI 820

  Fly   892 SLGVEPVDHDVLKQKPRNVKQPMITKSVVVNVLLSASIIVLGTL--------------------- 935
            ||..|..:.|::|::|||.|    |..:|...|:|.:...:|.:
Mouse   821 SLAYEQAESDIMKRQPRNPK----TDKLVNERLISMAYGQIGMIQALGGFFTYFVILAENGFLPF 881

  Fly   936 ------------WVFQREMADGTLGKTKRDTTMTFTCFVFF-------DMFNALSCRSQTKSVFT 981
                        ||...|.:.|.....::...:.|||...|       ...:.:.|:::..|||.
Mouse   882 HLLGIRETWDDRWVNDVEDSYGQQWTYEQRKIVEFTCHTAFFVSIVVVQWADLVICKTRRNSVFQ 946

  Fly   982 IGLTTNRMFLLAVAFSIIGQMLVVYFPPLQMVFQTEALTPYDIFFLVSLTSSVLVVSEIKK---- 1042
            .|: .|::.:..:.........:.|.|.:....:...|.|...|.....:..:.|..|::|
Mouse   947 QGM-KNKILIFGLFEETALAAFLSYCPGMGAALRMYPLKPTWWFCAFPYSLLIFVYDEVRKLIIR 1010

  Fly  1043 -----WFER 1046
                 |.|:
Mouse  1011 RRPGGWVEK 1019

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPoCk	NP_001262220.1	ATPase-IIA2_Ca	110..1049	CDD:130585	297/1046 (28%)
		Cation_ATPase_N	112..179	CDD:279080	19/69 (28%)
		E1-E2_ATPase	191..425	CDD:278548	79/241 (33%)
		Cation_ATPase	496..579	CDD:289987	29/96 (30%)
		COG4087	<760..823	CDD:226572	42/62 (68%)
		Cation_ATPase_C	872..1044	CDD:279079	44/220 (20%)
Atp1a1	NP_659149.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..39		13/55 (24%)
		ATPase-IIC_X-K	29..1023	CDD:273445	301/1076 (28%)
		Cation_ATPase_N	40..114	CDD:214842	20/85 (24%)
		Phosphoinositide-3 kinase binding. /evidence=ECO:0000250	82..84		0/1 (0%)
		E1-E2_ATPase	134..365	CDD:278548	79/241 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	216..235		9/20 (45%)
		Cation_ATPase	427..521	CDD:289987	29/96 (30%)
		COG4087	606..>732	CDD:226572	50/159 (31%)
		Cation_ATPase_C	799..1008	CDD:279079	44/213 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920