Protein Alignment SPoCk and Atp1a1

DIOPT Version :10

• Sequence 1: NP_001262220.1
• Gene: SPoCk / 40495
• FlyBaseID: FBgn0052451
• Length: 1062
• Species: Drosophila melanogaster
• Sequence 2: NP_659149.1
• Gene: Atp1a1 / 11928
• MGIID: 88105
• Length: 1023
• Species: Mus musculus
• Alignment Length: 1114
• Identity: 311/1114 - (27%)
• Similarity: 483/1114 - (43%)
• Gaps: 206/1114 - (18%)

  Fly    42 KGVDSKPNPQRTISHVKDSRAVPQNVKPGKVADMKDCKEPDEDNVDQQNGNIIQTGLTLTPEMLL 106
            |||.........:|...|        |.||.|.    ||.|.|.:.::        :::....|
Mouse     3 KGVGRDKYEPAAVSEHGD--------KKGKKAK----KERDMDELKKE--------VSMDDHKL- 46

  Fly   107 STSESSTHSASEVAGRLQVDVRTGLKWTEAKYRAKII---GHNELLLVAEDPTWKKYIEQFRNPL 168
                    |..|:..:...|:..||  |.|: .|:|:   |.|.|......|.|.|:..|.....
Mouse    47 --------SLDELHRKYGTDLSRGL--TPAR-AAEILARDGPNALTPPPTTPEWVKFCRQLFGGF 100

  Fly   169 ILLLLGSALVSVIMKQFDDA-----------VSITIAILIVVT--VAFIQEYRSEKSLEELKKLV 220
            .:||...|::..:......|           :.:.::.::::|  .::.||.:|.|.:|..|.:|
Mouse   101 SMLLWIGAILCFLAYGIRSATEEEPPNDDLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMV 165

  Fly   221 PPECHCLREGRLDTFLARELVPGDIVHLNVGDRVPADVRLFEAVDLSIDESSFTGETEPARKITD 285
            |.:...:|.|...:..|.::|.||:|.:..|||:|||:|:..|....:|.||.|||:||..:..|
Mouse   166 PQQALVIRNGEKMSINAEDVVVGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEPQTRSPD 230

  Fly   286 VLLNNTNVKDHSNMKNIAFMGTLVRCGNGKGIVVSTGERSEFGEVFKMMQAEEAPKTPLQKSMD- 349
              ..|.|..:   .:||||..|....|..:||||.||:|:..|.:..:....|..:||:.:.::
Mouse   231 --FTNENPLE---TRNIAFFSTNCVEGTARGIVVYTGDRTVMGRIATLASGLEGGQTPIAEEIEH 290

  Fly   350 ----ILGAQLSF-YSFLIIGVIMLLGWLQGKPLSEMFNISVSLAVAAIPEGLPIVVTVTLALGVM 409
                |.|..:.. .||.|:.:|:...||      |.....:.:.||.:||||...|||.|.|...
Mouse   291 FIHLITGVAVFLGVSFFILSLILEYTWL------EAVIFLIGIIVANVPEGLLATVTVCLTLTAK 349

  Fly   410 RMAKRNSIVKKLPTVETLGCVNVICSDKTGTLTKNEMT-ATIIITSDGYMADVTGAGYNDQGEIH 473
            |||::|.:||.|..|||||..:.||||||||||:|.|| |.:...:..:.||.|   .|..|
Mouse   350 RMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTT---ENQSG--- 408

  Fly   474 IRHCNNVEMAKTNIT--NLLEIGAVCNNAYIQ---------NGTLLGQPTEGAL---VAVAMKNG 524
                  |...||:.|  .|..|..:||.|..|         ...:.|..:|.||   :.|...:.
Mouse   409 ------VSFDKTSATWFALSRIAGLCNRAVFQANQENLPILKRAVAGDASESALLKCIEVCCGSV 467

  Fly   525 MYATAENYVRIQEYPFSSEQKMMAVKCIHKYNNNKE--EIFFAKGALETLLPQCTKYQFGTQTVP 587
            | ...|.|.:|.|.||:|..|...  .|||..|..|  .:...|||.|.:|.:|:......:..|
Mouse   468 M-EMREKYSKIVEIPFNSTNKYQL--SIHKNPNASEPKHLLVMKGAPERILDRCSSILLHGKEQP 529

  Fly   588 LTKQNEAEFLAEAYEIGRKGLRVLALAK-------------------GRSMQDLIYCGLVGITDP 633
            |.::.:..|.....|:|..|.|||....                   ...:.:|.:.||:.:.||
Mouse   530 LDEELKDAFQNAYLELGGLGERVLGFCHLLLPDEQFPEGFQFDTDDVNFPVDNLCFVGLISMIDP 594

  Fly   634 PRPLVRESIEMLMQSGVRVKMVTGDAQETALAIDPSRRLQAVPTHAIPAWPTAGGVPLCSASACC 698
            ||..|.:::.....:|::|.|||||                   |.|.|...|.||.:.|..
Mouse   595 PRAAVPDAVGKCRSAGIKVIMVTGD-------------------HPITAKAIAKGVGIISEG--- 637

  Fly   699 STNCLENAMKEIYLTALAQQGLPLVTANLIGIDTIHHQTLSGQEMDQMNEHQLDKVA--NNVSVF 761
                 ...:::|    .|:..:|:   |.:.........:.|.::..|...:||.:.  :...||
Mouse   638 -----NETVEDI----AARLNIPV---NQVNPRDAKACVVHGSDLKDMTSEELDDILRYHTEIVF 690

  Fly   762 YRVSPRHKLEIVKSLQRSGNIVGMTGDGVNDGVALKKADIGIAMGKNGTDVCKEAADMILVNDDF 826
            .|.||:.||.||:..||.|.||.:|||||||..||||||||:|||..|:||.|:||||||::|:|
Mouse   691 ARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIVGSDVSKQAADMILLDDNF 755

  Fly   827 HTIIAAIEEGKGIFYNIRNFVRFQLSTSIAALALIALATLMDIANPLNAMQILWINIIMDGPPAQ 891
            .:|:..:|||:.||.|::..:.:.|:::|..:....:..:.:|..||..:.||.|::..|..||.
Mouse   756 ASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLIFIIANIPLPLGTVTILCIDLGTDMVPAI 820

  Fly   892 SLGVEPVDHDVLKQKPRNVKQPMITKSVVVNVLLSASIIVLGTL--------------------- 935
            ||..|..:.|::|::|||.|    |..:|...|:|.:...:|.:
Mouse   821 SLAYEQAESDIMKRQPRNPK----TDKLVNERLISMAYGQIGMIQALGGFFTYFVILAENGFLPF 881

  Fly   936 ------------WVFQREMADGTLGKTKRDTTMTFTCFVFF-------DMFNALSCRSQTKSVFT 981
                        ||...|.:.|.....::...:.|||...|       ...:.:.|:::..|||.
Mouse   882 HLLGIRETWDDRWVNDVEDSYGQQWTYEQRKIVEFTCHTAFFVSIVVVQWADLVICKTRRNSVFQ 946

  Fly   982 IGLTTNRMFLLAVAFSIIGQMLVVYFPPLQMVFQTEALTPYDIFFLVSLTSSVLVVSEIKK---- 1042
            .|: .|::.:..:.........:.|.|.:....:...|.|...|.....:..:.|..|::|
Mouse   947 QGM-KNKILIFGLFEETALAAFLSYCPGMGAALRMYPLKPTWWFCAFPYSLLIFVYDEVRKLIIR 1010

  Fly  1043 -----WFER 1046
                 |.|:
Mouse  1011 RRPGGWVEK 1019

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SPoCk	NP_001262220.1	P-type_ATPase_SPCA	139..1042	CDD:319779	287/1002 (29%)
Atp1a1	NP_659149.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..39		13/55 (24%)
		ATPase-IIC_X-K	29..1023	CDD:273445	301/1076 (28%)
		Phosphoinositide-3 kinase binding. /evidence=ECO:0000250	82..84		0/1 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	216..235		9/20 (45%)
		Mediates interaction with SCN7A. /evidence=ECO:0000269|PubMed:17408578	596..717		39/154 (25%)