Protein Alignment SPoCk and Atp2a1

DIOPT Version :10

• Sequence 1: NP_001262220.1
• Gene: SPoCk / 40495
• FlyBaseID: FBgn0052451
• Length: 1062
• Species: Drosophila melanogaster
• Sequence 2: NP_478120.1
• Gene: Atp2a1 / 116601
• RGDID: 621293
• Length: 994
• Species: Rattus norvegicus
• Alignment Length: 1052
• Identity: 330/1052 - (31%)
• Similarity: 510/1052 - (48%)
• Gaps: 182/1052 - (17%)

  Fly   112 STHSAS--EVAGRLQVDVRTGLKWTEAKYRAKIIGHNELLLVAEDPTWKKYIEQFRNPLILLLLG 174
            :.||.|  |......|...|||...:.|...:..|.|||........|:..:|||.:.|:.:||.
  Rat     3 AAHSKSTEECLSYFGVSETTGLTPDQVKRHLEKYGPNELPAEEGKSLWELVVEQFEDLLVRILLL 67

  Fly   175 SALVSVIMKQFDDA-------VSITIAILIVVTVAFI---QEYRSEKSLEELKKLVPPECHCLRE 229
            :|.:|.::..|::.       |...:.:||::..|.:   ||..:|.::|.||:..|......|.
  Rat    68 AACISFVLAWFEEGEETVTAFVEPFVILLILIANAIVGVWQERNAENAIEALKEYEPEMGKVYRA 132

  Fly   230 GR--LDTFLARELVPGDIVHLNVGDRVPADVRL--FEAVDLSIDESSFTGETEPARKITDVLLNN 290
            .|  :....||::||||||.:.|||:||||:|:  .::..|.:|:|..|||:....|.||.:.:.
  Rat   133 DRKSVQRIKARDIVPGDIVEVAVGDKVPADIRILSIKSTTLRVDQSILTGESVSVIKHTDPVPDP 197

  Fly   291 TNVKDHSNMKNIAFMGTLVRCGNGKGIVVSTGERSEFGEVFKMMQAEEAPKTPLQKSMDILGAQL 355
            ..|  :.:.||:.|.||.:..|...|||.:||..:|.|::...|.|.|..|||||:.:|..|.||
  Rat   198 RAV--NQDKKNMLFSGTNIAAGKAVGIVATTGVSTEIGKIRDQMAATEQDKTPLQQKLDEFGEQL 260

  Fly   356 SFYSFLIIGVIMLL------------GWLQGKPLSEMFNISVSLAVAAIPEGLPIVVTVTLALGV 408
            |....||...:.|:            .|.:|  ....|.|:|:|||||||||||.|:|..||||.
  Rat   261 SKVISLICVAVWLINIGHFNDPVHGGSWFRG--AIYYFKIAVALAVAAIPEGLPAVITTCLALGT 323

  Fly   409 MRMAKRNSIVKKLPTVETLGCVNVICSDKTGTLTKNEMTAT---IIITSDGYMA-----DVTGAG 465
            .||||:|:||:.||:||||||.:|||||||||||.|:|:..   ||...||.:.     .:||:.
  Rat   324 RRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCKMFIIDKVDGDICSLNEFSITGST 388

  Fly   466 YNDQGEIHIRHCNNVEMAK-TNITNLLEIGAVCNNAYIQ-NGT-----LLGQPTEGALVAVAMKN 523
            |..:||: :::...|...: ..:..|..|.|:||::.:. |.|     .:|:.||.||..:..|.
  Rat   389 YAPEGEV-LKNDKPVRAGQYDGLVELATICALCNDSSLDFNETKGVYEKVGEATETALTTLVEKM 452

  Fly   524 GMY------------ATAENYVRIQ----EY--PFSSEQKMMAVKCIHKYNN-----NKEEIFFA 565
            .::            |.|.|.|..|    |:  .||.::|.|:|.|....::     ||   .|.
  Rat   453 NVFNTEVRSLSKVERANACNSVIRQLMKKEFTLEFSRDRKSMSVYCSPAKSSRAAVGNK---MFV 514

  Fly   566 KGALETLLPQCTKYQFGTQTVPLTKQNEAEFLA--EAYEIGRKGLRVLALA------KGRSM--- 619
            |||.|.::.:|...:.||..||||...:.:.::  :.:..||..||.||||      |...|
  Rat   515 KGAPEGVIDRCNYVRVGTTRVPLTGPVKEKIMSVIKEWGTGRDTLRCLALATRDTPPKREEMVLD 579

  Fly   620 ---------QDLIYCGLVGITDPPRPLVRESIEMLMQSGVRVKMVTGDAQETALAIDPSRRLQAV 675
                     .||.:.|:||:.||||..|..||::...:|:||.|:|||.:.||:||
  Rat   580 DSAKFMEYEMDLTFVGVVGMLDPPRKEVTGSIQLCRDAGIRVIMITGDNKGTAIAI--------- 635

  Fly   676 PTHAIPAWPTAGGVPLCSASACCSTNCLENAMKEIYLTALAQQGLPLVTANLIGIDTIHHQTLSG 740
                            |......|.|                             :.:..:..:|
  Rat   636 ----------------CRRIGIFSEN-----------------------------EEVADRAYTG 655

  Fly   741 QEMDQMNEHQLDKVANNVSVFYRVSPRHKLEIVKSLQRSGNIVGMTGDGVNDGVALKKADIGIAM 805
            :|.|.:...:..:.......|.||.|.||.:||:.||....|..||||||||..|||||:|||||
  Rat   656 REFDDLPLAEQREACRRACCFARVEPSHKSKIVEYLQSYDEITAMTGDGVNDAPALKKAEIGIAM 720

  Fly   806 GKNGTDVCKEAADMILVNDDFHTIIAAIEEGKGIFYNIRNFVRFQLSTSIAALALIALATLMDIA 870
            | :||.|.|.|::|:|.:|:|.||:||:|||:.|:.|::.|:|:.:|:::..:..|.|...:.:.
  Rat   721 G-SGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGLP 784

  Fly   871 NPLNAMQILWINIIMDGPPAQSLGVEPVDHDVLKQKPRNVKQPMIT-----KSVVVNVLLSASII 930
            ..|..:|:||:|::.||.||.:||..|.|.|::.:.||:.|:|:|:     :.:.:...:.|:.:
  Rat   785 EALIPVQLLWVNLVTDGLPATALGFNPPDLDIMDRPPRSPKEPLISGWLFFRYMAIGGYVGAATV 849

  Fly   931 VLGTLWVFQREMADG--------------------------TLGKTKRDTTMTFTCFVFFDMFNA 969
            .....|....|  ||                          .:.:.....||..:..|..:|.||
  Rat   850 GAAAWWFLYAE--DGPHVSYHQLTHFMQCTEHNPEFDGLDCEVFEAPEPMTMALSVLVTIEMCNA 912

  Fly   970 LSCRSQTKSVFTIGLTTNRMFLLAVAFSIIGQMLVVYFPPLQMVFQTEALTPYDIFFLVSLTSSV 1034
            |:..|:.:|:..:....|...|.::..|:....|::|..||.|:|:..||.......::.::..|
  Rat   913 LNSLSENQSLLRMPPWVNIWLLGSICLSMSLHFLILYVDPLPMIFKLRALDFTQWLMVLKISLPV 977

  Fly  1035 LVVSEIKKWFER 1046
            :.:.|:.|:..|
  Rat   978 IGLDELLKFIAR 989

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SPoCk	NP_001262220.1	P-type_ATPase_SPCA	139..1042	CDD:319779	319/1017 (31%)
Atp2a1	NP_478120.1	P-type_ATPase_SERCA	5..989	CDD:319778	329/1048 (31%)
		Interaction with PLN. /evidence=ECO:0000250|UniProtKB:P04191	788..808		8/19 (42%)
		Interaction with PLN. /evidence=ECO:0000250|UniProtKB:P04191	932..943		2/10 (20%)