DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SPoCk and atp13a1

DIOPT Version :9

Sequence 1:	NP_001262220.1	Gene:	SPoCk / 40495	FlyBaseID:	FBgn0052451	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	NP_001121512.1	Gene:	atp13a1 / 100158629	XenbaseID:	XB-GENE-984166	Length:	1174	Species:	Xenopus tropicalis

Alignment Length:	851	Identity:	189/851 - (22%)
Similarity:	331/851 - (38%)	Gaps:	213/851 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 PQNVKPGKVADMKDCKEPDEDNVDQQNGNIIQTGLTLTPEMLLSTSESSTHSASEVAGRLQV--- 125
            |.|..|..|..:|:.:|..::|:..:...|                 ..::.|.|..|.|||
Frog   110 PNNGSPELVPLIKEKQEDGKENIFFEFQKI-----------------KYSYDAEEKKGFLQVVFP 157

  Fly   126 ----------------DVRTGLKWTEAKYRAKIIGHNELLLVAEDPTWKKYIEQFRNPLILLLLG 174
                            ||  .:|..|.||     |.|:..:|..|     ::..|:...|.....
Frog   158 LERQLSYYQNAKGYMEDV--DIKAAEKKY-----GTNKAEMVVPD-----FLHLFKERAIAPFFV 210

  Fly   175 SALVSVIMKQFDD----AVSITIAILIVVTVAFIQEYRSEKSLEELKKL--VPPECHCLREGRLD 233
            ..:..|.:...|:    :| .|:.:|:....:.:|:  ..|:|.|::|:  .|......|..:..
Frog   211 FQVFCVGLWCLDEYWYYSV-FTLFMLVAFEASLVQQ--QMKNLSEIRKMGNKPYMIQVYRNRKWR 272

  Fly   234 TFLARELVPGDIVHL--NVGDR-VPADVRLFEAVDLSIDESSFTGETEPARKITDVLLNNTNVKD 295
            ...:.|::|||||.:  :..|. ||.||.|.....: |||:..|||:.|..|.....||..:|.|
Frog   273 PISSDEIIPGDIVSIGRSANDNLVPCDVLLLRGRCI-IDEAMLTGESVPQMKEPVEELNPEHVLD 336

  Fly   296 HS--NMKNIAFMGT--------------LVRCGNG-KGIVVSTGERSEFGEVFK--MMQAEEAPK 341
            .|  :..::.|.||              |....|| ...|:.||..:..|::.:  :...:....
Frog   337 VSADSKLHVIFGGTKVVQHTPPQKATSGLKPVDNGCVAYVLRTGFNTSQGKLLRTILFGVKRVTA 401

  Fly   342 TPLQKSMDILGAQLSFYSFLIIGVIMLLG--WLQG--KPLSEMFNISVS---LAVAAIPEGLPIV 399
            ..|:..:.||        ||::..|....  |::|  .|....:.:.:.   :..:.:|..|||.
Frog   402 NNLETFIFIL--------FLLVFAIAAAAYVWIEGTKDPSRNRYKLFLECTLILTSVVPPELPIE 458

  Fly   400 VTVTLALGVMRMAKRNSIVKKLPTVETLGCVNVICSDKTGTLTKNEMTATIIITSDGYMADVTG- 463
            :::.:...::.:||......:...:...|.|.:.|.|||||||.:.:.             |.|
Frog   459 LSLAVNTSLIALAKLYVYCTEPFRIPFAGKVEICCFDKTGTLTSDSLV-------------VRGV 510

  Fly   464 AGYNDQGEIHIRHCNNVEMAKTNITNL----LEIGAVCNN-AYIQNGTLLGQPTEGALVAVAMKN 523
            ||..|..|:            |.|:::    ..:.|.|:: ..:.:|||:|.|.|.|::
Frog   511 AGLKDGKEV------------TPISDIPVDTHRVVATCHSLVQMDDGTLVGDPLEKAML------ 557

  Fly   524 GMYATAENY-----------------VRI-QEYPFSSEQKMMAVKCIHKYNNNKEEIFFA--KGA 568
                ||.::                 ::| |.:.|:|..|.|:|...::...:.:..:.|  |||
Frog   558 ----TAVDWTLTKDEKVFSKSIKTQGLKIHQRFHFASSLKRMSVLASYERPGSTDLCYVATVKGA 618

  Fly   569 ---LETLLPQCTKYQFGTQTVPLTKQNEAEFLAEAYEIGRKGLRVLALA----------KGRSMQ 620
               |.|:...|.:|.....|                ||.|:|.|||||.          :.|.|:
Frog   619 PETLHTMFSHCPEYYNQVHT----------------EISREGARVLALGYKELGHLTHQQVREMK 667

  Fly   621 ------DLIYCGLVGITDPPRPLVRESIEMLMQSGVRVKMVTGDAQETALAIDPSRRLQAV-PTH 678
                  ||.:.|.:.::.|.:...:..|:.:..:...|.|:|||...||..:  :..|..: ..|
Frog   668 REMLECDLRFAGFIVVSCPLKADSKAVIKEIQNASHHVVMITGDNPLTACHV--AEELNFIEKQH 730

  Fly   679 AIPAWPTAGGVPLCSASACCSTNCLENAMKEIYLTALAQQGLPLVTANLIGIDTIHHQTLSGQEM 743
            .:...|...     :..:|.....::..:           .||....|:....:.::..|:|:.:
Frog   731 TLVLQPIQD-----TRDSCWMWQSIDGTI-----------SLPAFPDNIQAFCSNYYLCLTGEGL 779

  Fly   744 DQMNEHQLDKV---ANNVSVFYRVSPRHKLEIVKSLQRSGNIVGMTGDGVNDGVALKKADIGIAM 805
            ..:...:.|.:   ..:|.||.||:|:.|..::.||:..|.:..|.|||.||..|||.|.:|:|:
Frog   780 SYLQSVRRDMLLAFIPHVQVFARVAPKQKEFVITSLKELGYVTLMCGDGTNDVGALKHAHVGVAL 844

  Fly   806 GKNGTD 811
            ..|..:
Frog   845 LANAPE 850

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPoCk	NP_001262220.1	ATPase-IIA2_Ca	110..1049	CDD:130585	181/805 (22%)
		Cation_ATPase_N	112..179	CDD:279080	18/85 (21%)
		E1-E2_ATPase	191..425	CDD:278548	59/264 (22%)
		Cation_ATPase	496..579	CDD:289987	24/106 (23%)
		COG4087	<760..823	CDD:226572	22/52 (42%)
		Cation_ATPase_C	872..1044	CDD:279079
atp13a1	NP_001121512.1	P-ATPase-V	73..1143	CDD:273738	189/851 (22%)
		E1-E2_ATPase	244..472	CDD:278548	55/238 (23%)
		Cation_ATPase	546..629	CDD:289987	21/92 (23%)
		COG4087	<784..854	CDD:226572	24/67 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910