Protein Alignment SPoCk and atp1a2

DIOPT Version :10

• Sequence 1: NP_001262220.1
• Gene: SPoCk / 40495
• FlyBaseID: FBgn0052451
• Length: 1062
• Species: Drosophila melanogaster
• Sequence 2: NP_001096439.1
• Gene: atp1a2 / 100125050
• XenbaseID: XB-GENE-6034696
• Length: 1020
• Species: Xenopus tropicalis
• Alignment Length: 1050
• Identity: 295/1050 - (28%)
• Similarity: 470/1050 - (44%)
• Gaps: 196/1050 - (18%)

  Fly   115 SASEVAGRLQVDVRTGLKWTEAKYRAKII---GHNELLLVAEDPTWKKYIEQ-FRNPLILLLLGS 175
            |..|:..:...|:..||  |.|: .|:::   |.|.|......|.|.|:..| |....|||.:|:
 Frog    45 SMEEIGRKYGTDLAKGL--TNAR-AAEVLAQDGPNALTPPPTTPEWVKFCRQLFGGFSILLWIGA 106

  Fly   176 AL------VSVIMKQFDDAVS------ITIAILIVVT--VAFIQEYRSEKSLEELKKLVPPECHC 226
            .|      :.:.|:  |:.::      :.:|.:::||  .::.||.:|.|.::..|.:||.:...
 Frog   107 ILCFLAYGIQIAME--DEPINDNLYLGVVLAAVVIVTGCFSYYQEAKSSKIMDSFKNMVPQQALV 169

  Fly   227 LREGRLDTFLARELVPGDIVHLNVGDRVPADVRLFEAVDLSIDESSFTGETEPARKITDVLLNNT 291
            :|||......|..:|.||:|.:..|||||||:|:..|....:|.||.|||:||..:..:.
 Frog   170 IREGEKLQINAEMVVVGDLVEIKGGDRVPADIRIIIAHGCKVDNSSLTGESEPQTRSPEF----- 229

  Fly   292 NVKDHSN---MKNIAFMGTLVRCGNGKGIVVSTGERSEFGEVFKMMQAEEAPKTPLQKSMD---- 349
               .|.|   .:||.|..|....|.|:|||::||:|:..|.:..:....|..:||:...::
 Frog   230 ---THENPLETRNICFFSTNCVEGTGRGIVINTGDRTVMGRIATLASGLEVGRTPIAMEIEHFIH 291

  Fly   350 -ILGAQLSF-YSFLIIGVIMLLGWLQGKPLSEMFNISVSLAVAAIPEGLPIVVTVTLALGVMRMA 412
             |.|..:.. .||.::.:|:...||      |.....:.:.||.:||||...|||.|.|...|||
 Frog   292 IITGVAVFLGVSFFVLSLILGYSWL------EAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMA 350

  Fly   413 KRNSIVKKLPTVETLGCVNVICSDKTGTLTKNEMT-ATIIITSDGYMADVTGAGYNDQGEIHIRH 476
            ::|.:||.|..|||||..:.||||||||||:|.|| |.:...:..:.||.|    .||..
 Frog   351 RKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTT----EDQSG----- 406

  Fly   477 CNNVEMAKTNITNLLEIGAVCNNAYIQNG---------TLLGQPTEGALV-AVAMKNG-MYATAE 530
             ...:......|.|..|..:||.|..:.|         ...|..:|.||: .:.:..| :....:
 Frog   407 -TTFDKRSPTWTALSRIAGLCNRAVFKVGQEKVAVSKRDTAGDASESALLKCIELSCGSVRKLRD 470

  Fly   531 NYVRIQEYPFSSEQKMMAVKCIHKYNNNKE-EIFFAKGALETLLPQCTKYQFGTQTVPLTKQNEA 594
            ...::.|.||:|..|...  .||:..::.| .:...|||.|.:|.:|:.........||.::.:.
 Frog   471 RNPKVAEIPFNSTNKFQL--SIHEREDSPEGHLLVMKGAPERILDRCSTIMLHGAEQPLDEEMKD 533

  Fly   595 EFLAEAYEIGRKGLRVLALA----------KGRS---------MQDLIYCGLVGITDPPRPLVRE 640
            .|....:|:|..|.|||...          :|..         :.||.:.||:.:.||||..|.:
 Frog   534 AFQNAYFELGGLGERVLGFCHLYIPADKFQRGFKFDTDEPNFPLTDLCFIGLISMIDPPRAAVPD 598

  Fly   641 SIEMLMQSGVRVKMVTGDAQETALAIDPSRRLQAVPTHAIPAWPTAGGVPLCSASACCSTNCLEN 705
            ::.....:|::|.|||||                   |.|.|...|.||.:.|.    ....:|:
 Frog   599 AVGKCRSAGIKVIMVTGD-------------------HPITAKAIAKGVGIISE----GNETVED 640

  Fly   706 AMKEIYLTALAQQGLPLVTANLIGIDTIHHQTLSGQEMDQMNEHQLDKVANNVS--VFYRVSPRH 768
            ....:        .:|:   |.:.........:.|.::..|...|||.:..|.:  ||.|.||:.
 Frog   641 IADRL--------NIPV---NQVNPREAKACVVHGSDLKDMTSEQLDDLLKNHTEIVFARTSPQQ 694

  Fly   769 KLEIVKSLQRSGNIVGMTGDGVNDGVALKKADIGIAMGKNGTDVCKEAADMILVNDDFHTIIAAI 833
            ||.||:..||.|.||.:|||||||..||||||||:|||..|:||.|:||||||::|:|.:|:..:
 Frog   695 KLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGV 759

  Fly   834 EEGKGIFYNIRNFVRFQLSTSIAALALIALATLMDIANPLNAMQILWINIIMDGPPAQSLGVEPV 898
            |||:.||.|::..:.:.|:::|..:....|..:.:|..||..:.||.|::..|..||.||..|..
 Frog   760 EEGRLIFDNLKKSIAYTLTSNIPEITPFLLFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEAA 824

  Fly   899 DHDVLKQKPRNVKQPMITKSVVVNVLLSAS------IIVLGTLWVFQREMADG------TLG--- 948
            :.|::|::|||.:    |..:|...|:|.:      |..||..:.:...:|:.      .||
 Frog   825 ESDIMKRQPRNPR----TDKLVNERLISMAYGQIGMIQALGGFFTYFVILAENGFLPSRLLGIRL 885

  Fly   949 ----KTKRDT--------------TMTFTCFVFF-------DMFNALSCRSQTKSVFTIGLTTNR 988
                ::..|.              .:.|||...|       ...:.:.|:::..|||..|: .|:
 Frog   886 DWDDRSNNDVEDSYGQEWTYEQRKVVEFTCHTAFFASIVVVQWADLIICKTRRNSVFQQGM-KNK 949

  Fly   989 MFLLAVAFSIIGQMLVVYFPPLQMVFQTEALT--------PYDIFFLVSLTSSVLVVSEIKK--- 1042
            :.:..:.........:.|.|.:.:..:...|.        ||.:.        :.:..|::|
 Frog   950 ILIFGLLEETALAAFLSYCPGMDVALRMYPLKVTWWFCAFPYSLL--------IFLYDEVRKLIL 1006

  Fly  1043 ------WFER 1046
                  |.|:
 Frog  1007 RRDPGGWVEK 1016

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SPoCk	NP_001262220.1	P-type_ATPase_SPCA	139..1042	CDD:319779	285/1011 (28%)
atp1a2	NP_001096439.1	ATPase-IIC_X-K	30..1020	CDD:273445	295/1049 (28%)