DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11241 and AGXT2

DIOPT Version :9

Sequence 1:	NP_001303389.1	Gene:	CG11241 / 40492	FlyBaseID:	FBgn0037186	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	NP_114106.1	Gene:	AGXT2 / 64902	HGNCID:	14412	Length:	514	Species:	Homo sapiens

Alignment Length:	493	Identity:	265/493 - (53%)
Similarity:	340/493 - (68%)	Gaps:	17/493 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 RSSVRRSSSSSVHSKAAPAMIAQMQGEMPDCNHRPAAYEGSTYEQILKTRRNHLTPNLLAHFKKP 80
            |:||   :..|:|:|.          .||.|:..|..|:...|.::|:..:.||:|.:.|:|:||
Human    34 RTSV---TKLSLHTKP----------RMPPCDFMPERYQSLGYNRVLEIHKEHLSPVVTAYFQKP 85

  Fly    81 LVIHAGHMQWLYDHEGRRYLDMFGGIVTVSVGHCHPKVNQALSEQTAKLWHTTNIYMHPKIHEYA 145
            |::|.|||:||:|.||.||||.|.|||||||||||||||....:|..:||||:.::.||.:||||
Human    86 LLLHQGHMEWLFDAEGSRYLDFFSGIVTVSVGHCHPKVNAVAQKQLGRLWHTSTVFFHPPMHEYA 150

  Fly   146 ERLVAKFPGDLKSVCFVNSGSEANDLAMLMARLYTGNQDILSLRNCYHGMSPYTMGLTAHSTWRF 210
            |:|.|..|..||.:..||||||||:|||||||.::.|.||:|.|..|||.||||:|||...|::.
Human   151 EKLAALLPEPLKVIFLVNSGSEANELAMLMARAHSNNIDIISFRGAYHGCSPYTLGLTNVGTYKM 215

  Fly   211 PLPGVNSGLVHVMNPDPYQGIWGGSNCRDSPVQTTRKCQCTVG-CQAGDAYYNELEETFKYSLPR 274
            .||| .:|....|.||.::|.||||:||||||||.|||.|... |||.|.|..:.::|...|:.:
Human   216 ELPG-GTGCQPTMCPDVFRGPWGGSHCRDSPVQTIRKCSCAPDCCQAKDQYIEQFKDTLSTSVAK 279

  Fly   275 GKVAAMFAESIQGVGGTVQFPKGYLKRAAALVRANGGLFVADEVQTGFGRTGEHFWGFESHDYVP 339
             .:|..|||.||||.|.||:|||:||.|..||||.||:.:||||||||||.|.|||||::||.:|
Human   280 -SIAGFFAEPIQGVNGVVQYPKGFLKEAFELVRARGGVCIADEVQTGFGRLGSHFWGFQTHDVLP 343

  Fly   340 DIVTMAKGIGNGFPLAAVVTTPEIAASLSQAL-HFNTYGGNPMASAVGIAVLDVIEEEQLQRNSL 403
            ||||||||||||||:|||:||||||.||::.| ||||:||||||.|:|.|||:||:||.||.||.
Human   344 DIVTMAKGIGNGFPMAAVITTPEIAKSLAKCLQHFNTFGGNPMACAIGSAVLEVIKEENLQENSQ 408

  Fly   404 EVGTYFLKGLAELQQRFEIIGDVRGKGLMIGVELVGNREKRTPLATPHVLDIWEKCKDQGVLLGR 468
            |||||.|...|:|:..|||:|||||||||||:|:|.::....||....|..|.|.||..|:|:||
Human   409 EVGTYMLLKFAKLRDEFEIVGDVRGKGLMIGIEMVQDKISCRPLPREEVNQIHEDCKHMGLLVGR 473

  Fly   469 GGLHGNVLSMRPPLCLCAEDVEFALETLEEAFKFHMSK 506
            |.:......:.|.:|:...:|:||:|....|...||.:
Human   474 GSIFSQTFRIAPSMCITKPEVDFAVEVFRSALTQHMER 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11241	NP_001303389.1	GabT	55..501	CDD:223238	252/447 (56%)
CG11241	NP_001303389.1	OAT_like	80..500	CDD:99735	243/421 (58%)
AGXT2	NP_114106.1	GabT	65..508	CDD:223238	251/444 (57%)
AGXT2	NP_114106.1	OAT_like	70..505	CDD:99735	249/436 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144934
Domainoid	1	1.000	500	1.000	Domainoid score	I347
eggNOG	1	0.900	-	-		E1_COG0160
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12887
Inparanoid	1	1.050	538	1.000	Inparanoid score	I1195
Isobase	1	0.950	-	0.878984	Normalized mean entropy	S1462
OMA	1	1.010	-	-		QHG63788
OrthoDB	1	1.010	-	-		D145181at2759
OrthoFinder	1	1.000	-	-		FOG0000701
OrthoInspector	1	1.000	-	-		oto88352
orthoMCL	1	0.900	-	-		OOG6_101753
Panther	1	1.100	-	-	LDO	PTHR45688
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2035
SonicParanoid	1	1.000	-	-		X3691
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750