DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11241 and ETNPPL

DIOPT Version :9

Sequence 1:	NP_001303389.1	Gene:	CG11241 / 40492	FlyBaseID:	FBgn0037186	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	NP_112569.2	Gene:	ETNPPL / 64850	HGNCID:	14404	Length:	499	Species:	Homo sapiens

Alignment Length:	445	Identity:	185/445 - (41%)
Similarity:	262/445 - (58%)	Gaps:	34/445 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 LKTRRNHLTPNLLAHF-KKPLVIHAGHMQWLYDHEGRRYLDMFGGIVTVSVGHCHPKVNQALSEQ 125
            |..|:.|:.|:....| ..|:.|.....|:::|..|.:|||....:  ..||||||.|.:|..:|
Human    11 LGLRKKHIGPSCKVFFASDPIKIVRAQRQYMFDENGEQYLDCINNV--AHVGHCHPGVVKAALKQ 73

  Fly   126 TAKLWHTTNIYMHPKIHEYAERLVAKFPGDLKSVC-FVNSGSEANDLAMLMARLYTGNQDILSLR 189
             .:|.:|.:.::|..|.|||:||.|..|..| ||| |.||||||||||:.:||.:.|:||:::|.
Human    74 -MELLNTNSRFLHDNIVEYAKRLSATLPEKL-SVCYFTNSGSEANDLALRLARQFRGHQDVITLD 136

  Fly   190 NCYHGMSPYTMGLTAHSTWRFPL-PGVNSGLVHVM-NPDPYQGIWGGSNCRDSPVQTTRKCQCTV 252
            :.|||   :...|...|.::|.. ..|....|||. .||.|:|.:...:
Human   137 HAYHG---HLSSLIEISPYKFQKGKDVKKEFVHVAPTPDTYRGKYREDH---------------- 182

  Fly   253 GCQAGDAYYNELEETFKYSLPRG-KVAAMFAESIQGVGGTVQFPKGYLKRAAALVRANGGLFVAD 316
             ..:..||.:|:::..:.:...| |:||..|||:|..||.:..|.||.::.|..|...||:|:||
Human   183 -ADSASAYADEVKKIIEDAHNSGRKIAAFIAESMQSCGGQIIPPAGYFQKVAEYVHGAGGVFIAD 246

  Fly   317 EVQTGFGRTGEHFWGFESH--DYVPDIVTMAKGIGNGFPLAAVVTTPEIAASLSQA--LHFNTYG 377
            |||.||||.|:|||.|:.:  |:|||||||.|.:|||.|:|.||||.|||.:.|.:  .:|||||
Human   247 EVQVGFGRVGKHFWSFQMYGEDFVPDIVTMGKPMGNGHPVACVVTTKEIAEAFSSSGMEYFNTYG 311

  Fly   378 GNPMASAVGIAVLDVIEEEQLQRNSLEVGTYFLKGLAELQQRFEIIGDVRGKGLMIGVELVGNRE 442
            |||::.|||:||||:||.|.||.|:..||.|..:.|.:.:.:..:|||:||.||.||::||.:..
Human   312 GNPVSCAVGLAVLDIIENEDLQGNAKRVGNYLTELLKKQKAKHTLIGDIRGIGLFIGIDLVKDHL 376

  Fly   443 KRTPLATPHVLDIWEKCKDQGVLLGRGGLHGNVLSMRPPLCLCAEDVEFALETLE 497
            |||| ||.....|..|.|::.|||...|.|.|||.::||:|...||.:|.::.|:
Human   377 KRTP-ATAEAQHIIYKMKEKRVLLSADGPHRNVLKIKPPMCFTEEDAKFMVDQLD 430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11241	NP_001303389.1	GabT	55..501	CDD:223238	185/445 (42%)
CG11241	NP_001303389.1	OAT_like	80..500	CDD:99735	180/426 (42%)
ETNPPL	NP_112569.2	PRK06148	<6..441	CDD:180426	185/445 (42%)
ETNPPL	NP_112569.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	468..499
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0160
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63788
OrthoDB	1	1.010	-	-		D145181at2759
OrthoFinder	1	1.000	-	-		FOG0000701
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.830