DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11241 and agxt2

DIOPT Version :9

Sequence 1:	NP_001303389.1	Gene:	CG11241 / 40492	FlyBaseID:	FBgn0037186	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	NP_001028922.1	Gene:	agxt2 / 619269	ZFINID:	ZDB-GENE-050913-100	Length:	517	Species:	Danio rerio

Alignment Length:	501	Identity:	254/501 - (50%)
Similarity:	351/501 - (70%)	Gaps:	14/501 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 RQLLPRSSVRRSSSSSVHSKAAPAMIAQMQG---------EMPDCNHRPAAYEGSTYEQILKTRR 66
            |.||.::.:|.|..:.|....|..::.|...         ::|..:.:|..|:|.:.|::|..|:
Zfish    11 RSLLGKTGLRSSVDACVKFHKAGGVLCQKTAVKHPSAVLPQIPPRDFKPEPYQGMSKERLLDIRK 75

  Fly    67 NHLTPNLL--AHFKKPLVIHAGHMQWLYDHEGRRYLDMFGGIVTVSVGHCHPKVNQALSEQTAKL 129
            ::..|..:  .::|||:.|:.||||||:|.:||||||:|.|:.|||||||:|||.:|..:|..:|
Zfish    76 HNCNPMTMKVTYYKKPVFINQGHMQWLWDVDGRRYLDLFAGVATVSVGHCNPKVTEAAEKQLRRL 140

  Fly   130 WHTTNIYMHPKIHEYAERLVAKFPGDLKSVCFVNSGSEANDLAMLMARLYTGNQDILSLRNCYHG 194
            ||||.||::|:|.||||:||:..|..||.|.|.||||||||||:|||||:|||.|.::||..|||
Zfish   141 WHTTPIYVYPQIQEYAEKLVSLLPDPLKVVYFTNSGSEANDLAVLMARLHTGNFDAITLRGSYHG 205

  Fly   195 MSPYTMGLTAHSTWRFPLPGVNSGLVHVMNPDPYQGIWGGSNCRDSPVQTTRKCQCTVG-CQAGD 258
            .||...||.:::.:::|:|. :.|..:.|.||.::|:||||:||||||||.|:|.|:.| |.|.|
Zfish   206 GSPQATGLMSNTHYKYPVPS-SLGCHNTMCPDVFRGLWGGSHCRDSPVQTIRECSCSPGHCYAND 269

  Fly   259 AYYNELEETFKYSLPRGKVAAMFAESIQGVGGTVQFPKGYLKRAAALVRANGGLFVADEVQTGFG 323
            .|..||:|.|..::| .::||.|.|.||||||.||:||.|||....|||..||:.:|||||||||
Zfish   270 MYIKELKEVFDTTVP-SRIAAFFTEPIQGVGGAVQYPKNYLKETYQLVREKGGICIADEVQTGFG 333

  Fly   324 RTGEHFWGFESHDYVPDIVTMAKGIGNGFPLAAVVTTPEIAASLSQALHFNTYGGNPMASAVGIA 388
            |||.||||||.|:.:||:|||||||.||.|:.|||||.|||.|.::.:||||:||||:|.|:..:
Zfish   334 RTGSHFWGFEGHNVIPDMVTMAKGIANGIPMGAVVTTAEIARSFAKGVHFNTFGGNPLACAIASS 398

  Fly   389 VLDVIEEEQLQRNSLEVGTYFLKGLAELQQRFEIIGDVRGKGLMIGVELVGNREKRTPLATPHVL 453
            |||.|:|:::|.||.|:|||.|..||:|:.::|||||||||||.||||:|.::..||||....:.
Zfish   399 VLDTIKEDKMQENSAELGTYLLTELAKLRDKYEIIGDVRGKGLQIGVEMVKDKASRTPLPQEAMN 463

  Fly   454 DIWEKCKDQGVLLGRGGLHGNVLSMRPPLCLCAEDVEFALETLEEA 499
            :|:|..||.|||:|:|||:|....::||:|:...|.:|.|....:|
Zfish   464 EIFEDTKDMGVLIGKGGLYGQTFRIKPPMCITKADADFFLSVFNQA 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11241	NP_001303389.1	GabT	55..501	CDD:223238	243/448 (54%)
CG11241	NP_001303389.1	OAT_like	80..500	CDD:99735	236/421 (56%)
agxt2	NP_001028922.1	GabT	65..510	CDD:223238	242/447 (54%)
agxt2	NP_001028922.1	OAT_like	73..510	CDD:99735	240/439 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578174
Domainoid	1	1.000	502	1.000	Domainoid score	I333
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12887
Inparanoid	1	1.050	533	1.000	Inparanoid score	I1171
OMA	1	1.010	-	-		QHG63788
OrthoDB	1	1.010	-	-		D145181at2759
OrthoFinder	1	1.000	-	-		FOG0000701
OrthoInspector	1	1.000	-	-		oto41528
orthoMCL	1	0.900	-	-		OOG6_101753
Panther	1	1.100	-	-	LDO	PTHR45688
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3691
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.910