DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11367 and tmem64

DIOPT Version :9

Sequence 1:	NP_649412.1	Gene:	CG11367 / 40491	FlyBaseID:	FBgn0037185	Length:	362	Species:	Drosophila melanogaster
Sequence 2:	NP_001121723.1	Gene:	tmem64 / 564172	ZFINID:	ZDB-GENE-060503-182	Length:	348	Species:	Danio rerio

Alignment Length:	321	Identity:	91/321 - (28%)
Similarity:	156/321 - (48%)	Gaps:	44/321 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 AAGNSEALFA--AQRTPDTSE-------------------DSECDPFLASRRATRSSATTSVLHN 105
            |||......:  .|||||:.:                   .::.||  |......||.|....|.
Zfish    17 AAGKGHIQLSRWLQRTPDSLDCDKIDILICNVFDERANGGKTDADP--AGLTEPASSFTPEFRHP 79

  Fly   106 RKRNSCWGRAHSFLTRNWYLGCLVPATILGALVFIGWATRDYARQLLFWIEMQNAWITFAVYMGL 170
            ....:|       ..::..|.|::.|....::..:    |.|.:.:|.|:|..::.:...:::..
Zfish    80 CCITTC-------CFKSALLACVLTAVCFSSVALV----RQYLKDVLLWVESLDSLVGAMLFIVG 133

  Fly   171 FALVSFPVVVGYFVLLITAGYLFGCLRGWVTVILGANIGIAVAHATIRSCRHRIPVQRLIKNDTG 235
            ...||||...||.||.:.||||:|.:.|...|::|..||..:||...:.......:.::..::..
Zfish   134 LITVSFPCGWGYIVLNVAAGYLYGFVLGMGLVMVGVLIGTFIAHVVCKRLLTNWVLSKIGSSEQL 198

  Fly   236 RAILRVISGPKAFRVVLFTRLTPIPFGVQNVIFGIS--SINTRDYHVATLIGLLPAQTINVYLGS 298
            .|::||:.|....:||...||||||||:||.:|.:|  .::..:|.||:.:||||.|.:|.|||:
Zfish   199 SAVIRVVEGGSGLKVVALARLTPIPFGLQNAVFSVSITDVSLPNYLVASSVGLLPTQLLNSYLGT 263

  Fly   299 TLRSMHEVLSDNDTKLTGYISFLFEVICGVALMFWVLQKARKELSETL------LSADYNN 353
            |||:|.:|:::.  .::||..|..::...:.|||:|:.:|:.||:..:      :...|.|
Zfish   264 TLRTMEDVIAEQ--SISGYFVFSLQIFISIGLMFYVVHRAQVELNAAIAACQMEMKTSYMN 322

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11367	NP_649412.1	DedA	150..340	CDD:223659	66/191 (35%)
CG11367	NP_649412.1	SNARE_assoc	180..298	CDD:286425	45/119 (38%)
tmem64	NP_001121723.1	TVP38	91..263	CDD:223475	57/175 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574785
Domainoid	1	1.000	87	1.000	Domainoid score	I8003
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H45636
Inparanoid	1	1.050	142	1.000	Inparanoid score	I4457
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1327131at2759
OrthoFinder	1	1.000	-	-		FOG0003179
OrthoInspector	1	1.000	-	-		oto39520
orthoMCL	1	0.900	-	-		OOG6_101862
Panther	1	1.100	-	-	LDO	PTHR46593
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5552
SonicParanoid	1	1.000	-	-		X5452
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.890