DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mael and MAEL

DIOPT Version :9

Sequence 1:	NP_788566.1	Gene:	mael / 40489	FlyBaseID:	FBgn0016034	Length:	462	Species:	Drosophila melanogaster
Sequence 2:	NP_116247.1	Gene:	MAEL / 84944	HGNCID:	25929	Length:	434	Species:	Homo sapiens

Alignment Length:	479	Identity:	86/479 - (17%)
Similarity:	181/479 - (37%)	Gaps:	110/479 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SGFMMFVNEWRNRNAEGRRMTL-----AQAVSHCGTIW--------EPFQKMNTQQRGPYNSGGK 58
            :.:..||.|   :..|.||..|     |.|:.:|.:.|        |.:.:|..:.|.   :.||
Human     9 NAYYFFVQE---KIPELRRRGLPVARVADAIPYCSSDWALLREEEKEKYAEMAREWRA---AQGK 67

  Fly    59 DANVAQRAKRESS--NGHGQVDKAQREATESLMDMKRTIERLVLNAKMSHDLENAKFVFVAFNYF 121
            |...:::.|...:  ...|.:...|..:...:..:....::.:|..           :|...|.|
Human    68 DPGPSEKQKPVFTPLRRPGMLVPKQNVSPPDMSALSLKGDQALLGG-----------IFYFLNIF 121

  Fly   122 TKA----LTTDVYVPAEFAACEYSLKEGIRSIYSTMIDPGQIIFGQGSDALLHSSTTHDLPLPPN 182
            :..    .....::|.|....:|||:|||.:.:.:.|:||:|..|........|.::|.:|:...
Human   122 SHGELPPHCEQRFLPCEIGCVKYSLQEGIMADFHSFINPGEIPRGFRFHCQAASDSSHKIPISNF 186

  Fly   183 ALGEKNMTKLYRNIVDYLSKCQGKGKTLVVFTPAENITMVKSCFRYLECDDDFRDGGEKIQVFDI 247
            ..|....|.| :|:..::.  ...|....::..:::.|.|..|.:::....:.|...:.:.|.|:
Human   187 ERGHNQATVL-QNLYRFIH--PNPGNWPPIYCKSDDRTRVNWCLKHMAKASEIRQDLQLLTVEDL 248

  Fly   248 QYLLFILKKEVMNVADLNDEKINKFATDAFFKK----DFFEFTAGIACQYHEDNDRTKYCTQSMV 308
                         |..:..:|..|..:..:.:.    ..:::::...|::||:|| ..:|..::.
Human   249 -------------VVGIYQQKFLKEPSKTWIRSLLDVAMWDYSSNTRCKWHEEND-ILFCALAVC 299

  Fly   309 TRWAYTFTDFMCGDLAITVQPGKHIPAQTKPNYLIISSYASSLDHESSFDSFYSLPGSGVKKESQ 373
            .:.||..::.:.....|.:... |:|.|               |:|:|             ....
Human   300 KKIAYCISNSLATLFGIQLTEA-HVPLQ---------------DYEAS-------------NSVT 335

  Fly   374 PEACSLSSSR---LSVASSSYKPIDHTSFAANLN-EVSEFPS----LGMRNSSKHHGIAASAQRE 430
            |:...|.:.|   |.|.||.:...:.::.....| .:.::||    .|..:|.:..||
Human   336 PKMVVLDAGRYQKLRVGSSGFSHFNSSNEEQRSNTPIGDYPSRAKISGQNSSVRGRGI------- 393

  Fly   431 WNARNLPTHSRLIRKVSDNDFSVN 454
                     :||:..:|::..:::
Human   394 ---------TRLLESISNSSSNIH 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mael	NP_788566.1	Maelstrom	126..339	CDD:289764	42/216 (19%)
MAEL	NP_116247.1	HMG_box_2	5..72	CDD:286146	17/68 (25%)
		Maelstrom	130..326	CDD:315648	41/213 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	357..385		4/27 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147874
Domainoid	1	1.000	53	1.000	Domainoid score	I11410
eggNOG	1	0.900	-	-		E1_28M7A
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H13143
Inparanoid	1	1.050	55	1.000	Inparanoid score	I5438
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47416
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0009912
OrthoInspector	1	1.000	-	-		oto90549
orthoMCL	1	0.900	-	-		OOG6_109678
Panther	1	1.100	-	-	LDO	PTHR21358
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4636
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.790