DRSC/TRiP Functional Genomics Resources

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Protein Alignment ArfGAP3 and GIT2

DIOPT Version :9

Sequence 1:NP_001097664.2 Gene:ArfGAP3 / 40487 FlyBaseID:FBgn0037182 Length:553 Species:Drosophila melanogaster
Sequence 2:NP_476510.1 Gene:GIT2 / 9815 HGNCID:4273 Length:759 Species:Homo sapiens


Alignment Length:742 Identity:137/742 - (18%)
Similarity:233/742 - (31%) Gaps:285/742 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly    19 RLRAQPANKSCFDCAAKAPTWSSVTYGIFICIDCSAVHRNLGVHLTFVRSTNLDTNW--TWLQLR 81
            |||   :::.|.||:...|:|:||..|.|:|.:|.:|||:||.|::.||... .|.|  |.||:.
Human     4 RLR---SSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLK-HTPWPPTLLQMV 64

  Fly    82 QMQLGGNANA-----------------------------AQFFRA--------HN--CSTTD--- 104
            :......||:                             |:|.||        |.  |...|   
Human    65 ETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPCRDDDSVT 129

  Fly   105 ---------------------------AQVKY------------NSRAAQLYRDKLCA------- 123
                                       ||..:            .|:|.|:.:.:|.|       
Human   130 AKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQILQAELLAVYGADPG 194

  Fly   124 -----------QAQQA----MKTHGTKLHLEQTDK------------------------------ 143
                       .|:|.    :.....::..|.||:                              
Human   195 TQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPDHKNGQHFIIPQMADSSLDL 259

  Fly   144 SEGNEAARE----------EDFFAQCDNEVD--------FNVQNNNVSKQDPNPPTVAPVISV-- 188
            ||..:||::          |:......:|||        ...||::....:   .||.|.:.|  
Human   260 SELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVWLATQNHSALVTE---TTVVPFLPVNP 321

  Fly   189 ---ETQQGGAPSVNLLNSVVPAAVPSSIGARKVQPKKG-GLGARKVGGLGATKVKTNFADIEARA 249
               .|:..|...:...|:...|.:...|.:...:.::| .|...|.......|...|...:|::.
Human   322 EYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQGSSLSGSKDNVELILKTINNQHSVESQD 386

  Fly   250 NAANEMKTSAAAAPVVKPQTAEDELETVASMR---------LAYQELSMQKTREEAKLKTMDPAK 305
            |...:..:.|:        ..:.:|||.||..         |:...:::|:..|.........||
Human   387 NDQPDYDSVAS--------DEDTDLETTASKTNRQKSLDSDLSDGPVTVQEFMEVKNALVASEAK 443

  Fly   306 AKQMERLGMGFNLRGSDMAHSALGDMETIQQSAAPKAKLSLLESENF------------------ 352
            .:|:.::            ::.|.|...|.|.     ||..|:|||.                  
Human   444 IQQLMKV------------NNNLSDELRIMQK-----KLQTLQSENSNLRKQATTNVYQVQTGSE 491

  Fly   353 FTDFSLYGNSSSGGGGGGSSEKRESSVGGTSKLDKFELDALGYETIEPIGGSHSNITSMFSRSND 417
            :||.|.:           ||.||..|..|:..:..:|..: |.:...|:|              :
Human   492 YTDTSNH-----------SSLKRRPSARGSRPMSMYETGS-GQKPYLPMG--------------E 530

  Fly   418 YDKPKTS----APVKKNSGSSQTHTKGGTSTDPVIAQQKFGNSKGFGSDQYFASEQSSADVSASL 478
            ..:|:.|    .|...:.|.|...|  .:|:.|           .|.|...::.::|:...|   
Human   531 ASRPEESRMRLQPFPAHIGRSALVT--SSSSLP-----------SFPSTLSWSRDESARRAS--- 579

  Fly   479 NRFQGSRAISSSDYF---GDGSPGGTGGNRA----------------SSVNFSAPDLDVESVKES 524
             |.:...:...|||.   .|..|.|.|.:|.                ::....||...:.|.::.
Human   580 -RLEKQNSTPESDYDNTPNDMEPDGMGSSRKGRQRSMVWPGDGLVPDTAEPHVAPSPTLPSTEDV 643

  Fly   525 VRQGVHKVAGRLSNLANDVMTSWQDKY 551
            :|: ..::...:..|......:..|.|
Human   644 IRK-TEQITKNIQELLRAAQENKHDSY 669

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ArfGAP3NP_001097664.2 ArfGap 17..121 CDD:214518 41/184 (22%)
GIT2NP_476510.1 ArfGap 2..124 CDD:214518 35/123 (28%)
ANK 109..220 CDD:238125 13/110 (12%)
ANK 1 132..161 2/28 (7%)
Ank_2 137..229 CDD:289560 11/91 (12%)
ANK repeat 137..165 CDD:293786 2/27 (7%)
ANK 2 166..195 5/28 (18%)
ANK repeat 167..197 CDD:293786 5/29 (17%)
ANK 3 199..228 3/28 (11%)
GIT_SHD 266..294 CDD:285690 5/27 (19%)
GIT_SHD 330..358 CDD:285690 4/27 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 379..422 9/50 (18%)
GIT_CC 414..478 CDD:293167 16/80 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 480..538 14/83 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 554..643 19/105 (18%)
GIT1_C 638..752 CDD:289013 5/33 (15%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5347
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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