DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ArfGAP3 and ASAP2

DIOPT Version :9

Sequence 1:	NP_001097664.2	Gene:	ArfGAP3 / 40487	FlyBaseID:	FBgn0037182	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	XP_011508705.1	Gene:	ASAP2 / 8853	HGNCID:	2721	Length:	1020	Species:	Homo sapiens

Alignment Length:	502	Identity:	111/502 - (22%)
Similarity:	182/502 - (36%)	Gaps:	128/502 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 QEI-ESVFSRLRAQPANKSCFDCAAKAPTWSSVTYGIFICIDCSAVHRNLGVHLTFVRSTNLDTN 74
            ||: :.:.|.::....|..|.||.|..|||.|...||..||:||.:||.||||.:.::|..||.
Human   431 QELTKEIISEVQRMTGNDVCCDCGAPDPTWLSTNLGILTCIECSGIHRELGVHYSRMQSLTLDV- 494

  Fly    75 WTWLQLRQMQLGGNANAAQFFRAHNCS-TTDAQVKYNSRAAQLYRDKLCAQAQQAMKTHGTKLHL 138
               |...::.|..|...|.|.....|. ..:..||.|. .:.:...|....|:...:.:..|.|.
Human   495 ---LGTSELLLAKNIGNAGFNEIMECCLPAEDSVKPNP-GSDMNARKDYITAKYIERRYARKKHA 555

  Fly   139 EQTDKSEG-NEAAREEDFF----AQCDNEVDFNVQNNNVSKQDPNPPTV-APVISVETQQGGAPS 197
            :...|... .||.:..|.|    |..|. ||...:....:..:|:...: ..|.||:     ..|
Human   556 DNAAKLHSLCEAVKTRDIFGLLQAYADG-VDLTEKIPLANGHEPDETALHLAVRSVD-----RTS 614

  Fly   198 VNLLNSVVPAAVPSSIGARKVQPKKGGLGARKVGGLGATKVK----TNFAD---IEARANAANEM 255
            :::::.:|              ...|.|.  |..|.|:|.:.    |:.|:   :..|..|:.|:
Human   615 LHIVDFLV--------------QNSGNLD--KQTGKGSTALHYCCLTDNAECLKLLLRGKASIEI 663

  Fly   256 KTSAAAAPV-----VKPQTAEDELETVAS------------MRLAYQELSMQKTREEAKLKTMDP 303
            ...:...|:     :|.:..|:.|....|            .||.:::|.......:.||:   |
Human   664 ANESGETPLDIAKRLKHEHCEELLTQALSGRFNSHVHVEYEWRLLHEDLDESDDDMDEKLQ---P 725

  Fly   304 AKAKQMERLGMGFNLRGSDMAHSALGDMETIQQSAAPKAKLSLLESENFFTDFSLYGNSSSGGGG 368
            :..::.:| .:.|...||:...|   :..::.:.||..||    |.:..|.. |:..|.:.|...
Human   726 SPNRREDR-PISFYQLGSNQLQS---NAVSLARDAANLAK----EKQRAFMP-SILQNETYGALL 781

  Fly   369 GGSSEKRESSVGGTSKLDKFELDALGYETIEPIGGSHSNITSMFSRSNDYDKPKTSAP--VKKNS 431
            .||....:.:...|                                        ||||  ..:|.
Human   782 SGSPPPAQPAAPST----------------------------------------TSAPPLPPRNV 806

  Fly   432 GSSQTHTKGGT--STDPVIAQQKFGNSKGFGSDQYFASEQSSADVSA 476
            |..||.:...|  .|:.|...   |.|:          ::||:|..|
Human   807 GKVQTASSANTLWKTNSVSVD---GGSR----------QRSSSDPPA 840

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ArfGAP3	NP_001097664.2	ArfGap	17..121	CDD:214518	34/104 (33%)
ASAP2	XP_011508705.1	BAR	34..259	CDD:299863
		PH_ASAP	311..417	CDD:270071
		PH	320..407	CDD:278594
		ArfGap	435..552	CDD:279720	36/121 (30%)
		ANK repeat	564..596	CDD:293786	8/32 (25%)
		ANK	<593..687	CDD:238125	20/114 (18%)
		ANK repeat	600..632	CDD:293786	8/52 (15%)
		Ank_5	621..675	CDD:290568	13/69 (19%)
		ANK repeat	634..665	CDD:293786	7/30 (23%)
		SH3_ASAP2	962..1017	CDD:212899
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810