DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ArfGAP3 and Acap2

DIOPT Version :9

Sequence 1:	NP_001097664.2	Gene:	ArfGAP3 / 40487	FlyBaseID:	FBgn0037182	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	XP_006522806.1	Gene:	Acap2 / 78618	MGIID:	1925868	Length:	816	Species:	Mus musculus

Alignment Length:	258	Identity:	59/258 - (22%)
Similarity:	110/258 - (42%)	Gaps:	54/258 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ASPAAG------PSKQEI---ESVFSRLRAQPANKSCFDCAAKAPTWSSVTYGIFICIDCSAVHR 57
            :||:.|      .||:::   ||...|::..|.|.||.||....|.|:|:..||.:||:||.:||
Mouse   389 SSPSTGSLDSGNESKEKLLKGESALQRVQCIPGNTSCCDCGLADPRWASINLGITLCIECSGIHR 453

  Fly    58 NLGVHLTFVRSTNLDTNWTW--------------------------LQLRQMQLGGNANAAQFFR 96
            :||||.:.|||..||   ||                          :.:::.|.|.......:.|
Mouse   454 SLGVHFSKVRSLTLD---TWEPELLKLMCELGNDVINRVYEAKLEKMGVKKPQPGQRQEKEAYIR 515

  Fly    97 AHNCSTTDAQVKYNSRAAQLYRDK-LCAQAQQAMKTHGTKLHLEQTDKSEGNEAAREEDFFAQCD 160
            |......... ||::..:...::| :.:::.:..:....:..:.....:..::.||.|..|  |.
Mouse   516 AKYVERKFVD-KYSALLSPSEQEKRIISKSCEDQRLSHARASVHTPVAAVTSDEARRESLF--CP 577

  Fly   161 NEVDFNVQNNNVSKQDPNPPTVAPVISVETQQGGAPSVNLLNSVVPAAVPSSIGARKVQPKKG 223
            :|:|     :..|..|    |.:.:.|:::...|   :...:.....::||::.|..:...:|
Mouse   578 DELD-----SLFSYFD----TSSKLRSIKSNDSG---IQQCSEDGRESLPSTVSANSLYEPEG 628

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ArfGAP3	NP_001097664.2	ArfGap	17..121	CDD:214518	36/130 (28%)
Acap2	XP_006522806.1	BAR_ACAP2	18..217	CDD:153322
		PH_ACAP	273..376	CDD:270070
		COG5347	398..>635	CDD:227651	56/249 (22%)
		ArfGap_ACAP2	410..524	CDD:350076	35/116 (30%)
		Ank_4	648..699	CDD:372654
		ANK repeat	676..709	CDD:293786
		PTZ00322	680..>764	CDD:140343
		ANK repeat	711..742	CDD:293786
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910