DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ArfGAP3 and Arfgap2

DIOPT Version :9

Sequence 1:	NP_001097664.2	Gene:	ArfGAP3 / 40487	FlyBaseID:	FBgn0037182	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_001159496.1	Gene:	Arfgap2 / 77038	MGIID:	1924288	Length:	534	Species:	Mus musculus

Alignment Length:	573	Identity:	219/573 - (38%)
Similarity:	315/573 - (54%)	Gaps:	67/573 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 AAGPSKQEIESVFSRLRAQPANKSCFDCAAKAPTWSSVTYGIFICIDCSAVHRNLGVHLTFVRST 69
            ||.|||.||:::|.||||.|.||:||||.||:|:|:|:|||:|:|||||.|||:|||||:|:|||
Mouse     2 AASPSKTEIQTIFKRLRAIPTNKACFDCGAKSPSWASITYGVFLCIDCSGVHRSLGVHLSFIRST 66

  Fly    70 NLDTNWTWLQLRQMQLGGNANAAQFFRAHNCSTTDAQVKYNSRAAQLYRDKLCAQAQQAMKTHGT 134
            .||:||:|||||.||:||||||..|||.|.|...||..||.|||||:||:|:......|:..|||
Mouse    67 ELDSNWSWLQLRCMQVGGNANATAFFRQHGCMANDANTKYTSRAAQMYREKIRQLGSAALTRHGT 131

  Fly   135 KLHLEQTDKSEGNEAAREE-DFFAQCDNEVDFNVQNNNVS-KQDPNPPTVAPVISVETQQGGAPS 197
            .|.::..:.:..:...::: |||.:......::....:.| .|.|..|:.:..:: :.:||  |:
Mouse   132 DLWIDSMNSAPSHSPEKKDSDFFTEHTQAPAWDTAATDPSGTQQPALPSESSSLA-QPEQG--PN 193

  Fly   198 VNLLNSVVPAAVPSS-----------------IGARKVQPKKGGLGARKVGGLGATKVKT-NFAD 244
            .:||.:...|::.|.                 ||.:|....|.||||:|  ||||.||.. :|.:
Mouse   194 TDLLGTSPQASLESMYLSAKGPSCTRELKSSIIGKKKPAAAKKGLGAKK--GLGAQKVSNQSFTE 256

  Fly   245 IEARANAANEMKTSAAAAPVVKPQTAEDELETVASMRLAYQELSMQKTREEAKLKTMDPAKAKQM 309
            ||.:|..|.:::...||.  .|.| ||:.:  |||||||||||.:.:.:||.||:.::..|.:|.
Mouse   257 IERQAQVAEKLREQQAAD--AKKQ-AEESM--VASMRLAYQELQIDRKKEEKKLQNLEGKKREQA 316

  Fly   310 ERLGMGFNLRGSDMAHSALGDMETIQQSAAPKAKLSLLESENFFTDFSLYGNSSSGGGGGGSSEK 374
            ||||||...| |.::||.|.:|:.|:|.....||.|.       :...|:.:..:...|....:.
Mouse   317 ERLGMGLVSR-SSISHSVLSEMQMIEQETPLSAKSSR-------SQLDLFDDVGTFASGPPKYKD 373

  Fly   375 RESSVGGTSKLDKFELDAL-GYETIEPIGGSHSNITSMFSRSNDYDKPKTSAPVKKNSGSS---Q 435
            ...|:|.|.. .:::.||. |.:.:|.   ....:|....|           |:.:.:.|.   :
Mouse   374 NPFSLGETFG-SRWDSDAAWGMDRVEE---KEPEVTISSIR-----------PISERTASRREVE 423

  Fly   436 THTKGGTSTDPVIAQQKFGNSKGFGSDQYFASE-QSSADVSASLNRFQGSRAISSSDYFGDGSPG 499
            |.:.|..|::   |:|||..:|...||.:|..| .|..:..:.|.:..||.||||||.||: ..|
Mouse   424 TRSSGLESSE---ARQKFAGAKAISSDMFFGREVDSEYEARSRLQQLSGSSAISSSDLFGN-MDG 484

  Fly   500 GTGGNRASSVNFSAPDLDVESVKESVRQGVHKVAGRLSNLANDVMTSWQDKYG 552
            ..||...|..|. .|..|:...|    |||..|||:::.|||.||.|.||:||
Mouse   485 AHGGGTVSLGNV-LPTADIAQFK----QGVKSVAGKMAVLANGVMNSLQDRYG 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ArfGAP3	NP_001097664.2	ArfGap	17..121	CDD:214518	71/103 (69%)
Arfgap2	NP_001159496.1	PLN03114	3..484	CDD:178661	194/517 (38%)
Arfgap2	NP_001159496.1	ArfGap	11..117	CDD:279720	71/105 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	172	1.000	Domainoid score	I3716
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8735
Inparanoid	1	1.050	328	1.000	Inparanoid score	I2442
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52037
OrthoDB	1	1.010	-	-		D1155557at2759
OrthoFinder	1	1.000	-	-		FOG0001852
OrthoInspector	1	1.000	-	-		otm42508
orthoMCL	1	0.900	-	-		OOG6_101784
Panther	1	1.100	-	-	O	PTHR45686
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R495
SonicParanoid	1	1.000	-	-		X1214
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.870