Protein Alignment ArfGAP3 and Arap1

DIOPT Version :9

• Sequence 1: NP_001097664.2
• Gene: ArfGAP3 / 40487
• FlyBaseID: FBgn0037182
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: XP_006508249.1
• Gene: Arap1 / 69710
• MGIID: 1916960
• Length: 1452
• Species: Mus musculus
• Alignment Length: 563
• Identity: 116/563 - (20%)
• Similarity: 193/563 - (34%)
• Gaps: 162/563 - (28%)

  Fly    16 VFSRLRAQPANKSCFDCAAKAPTWSSVTYGIFICIDCSAVHRNLGVHLTFVRSTNLDTN-WTWLQ 79
            |..|:.|...|:.|.||.|..|.|:|:...:.||..|:..||.||..::.|||..:|.. ||...
Mouse   539 VAERIWAAAPNRFCADCGAAQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTEAL 603

  Fly    80 LRQMQLGGNANAAQFFRAHNCSTTDAQVKYNSRAAQLYR-----------------------DK- 120
            ::.....||.....|:.| |...::|....:|..|:.|.                       ||
Mouse   604 IQLFLHLGNGPGNHFWAA-NVPPSEALEPSSSPGARRYHLEAKYREGKYRRYHPLFGNQEELDKA 667

  Fly   121 LCAQA-------QQAMKTHGTKLHLEQTDKSEGNEAAREEDFFAQCDNEVDFNVQNNNVSKQDPN 178
            |||..       .||:...|..:.....|.:.....|..|    |....:......||.|.:.|.
Mouse   668 LCAAVTTTDLAETQALLGCGAGVSCFSGDPAAPTPLALAE----QAGQTLQMEFLRNNQSTEVPR 728

  Fly   179 PPTVAPV---ISV------------ETQQGGAPSVN------------LLNSVVPAAVPSSIGAR 216
            ..:|.|:   .||            :|...|.|..:            :|:..|.:...:.   |
Mouse   729 LDSVKPLEKHYSVTLPTVSHSGFLYKTASAGKPLQDRRAREEFSRRWCVLSDGVLSYYENE---R 790

  Fly   217 KVQPKKGGLGARKVGGLGATKVKTN--------FADIE-------ARANAANEMKTSAAAAPVVK 266
            .|.| .|.:.|.::..|..:.:.|:        :.:.|       ..|..|:|.....|.|.|
Mouse   791 AVTP-NGEIRASEIVCLAVSPLDTHGFEHTFEVYTEGERLYLFGLENAELAHEWVKCIAKAFV-- 852

  Fly   267 PQTAED----ELETVASMRLAYQE-LSMQKTRE------EAKLKTM-------DPAKAKQMERLG 313
            |..|||    :.|.:.  ||..:. ||:|:.:|      .::|:.:       :|.:.::::.|
Mouse   853 PPLAEDLLARDFERLG--RLPCKAGLSLQQAQEGWFALTGSELRAVFPEGPWEEPLQLRKLQEL- 914

  Fly   314 MGFNLRGSDMAHSALGDMETIQQSAAPKAKLSLLESENFFTDFSLYGNSSSGGGGGGSSEKRESS 378
                        |..||.|........:.:...::.|... ||..:         .|..:|..:|
Mouse   915 ------------SIQGDSENQVLVLVERRRTLYIQGERRL-DFMAW---------LGVIQKAAAS 957

  Fly   379 VGGT---SKLDKFELDALGYETIEPIGGSHSNITS--MFSRSNDYDKPKTSAPVKKNSGSSQTHT 438
            :|.|   .:|...::..:.|..::.|  :...:||  ::.:.....|.:......:....| .|.
Mouse   958 LGDTLSEQQLGDSDIPVIVYRCVDYI--TQCGLTSEGIYRKCGQTSKTQRLLDSLRQDARS-VHL 1019

  Fly   439 KGGTSTDPVIAQQKFGNSKGFGSDQYFASEQSSADVSASLNRF 481
            |.|                          ||...|||::|.||
Mouse  1020 KEG--------------------------EQHVDDVSSALKRF 1036

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ArfGAP3	NP_001097664.2	ArfGap	17..121	CDD:214518	34/128 (27%)
Arap1	XP_006508249.1	SAM_Arap1,2,3	6..68	CDD:188889
		PH1_ARAP	331..422	CDD:270073
		PH2_ARAP	438..527	CDD:270074
		ArfGap_ARAP	537..652	CDD:350066	33/113 (29%)
		PH3_ARAP	745..851	CDD:270076	17/109 (16%)
		PH-like	864..954	CDD:388408	18/114 (16%)
		RhoGAP_ARAP	959..1137	CDD:239850	20/107 (19%)
		RA_ARAP1	1173..1265	CDD:340746
		PH5_ARAP	1265..1404	CDD:270079

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900