DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ArfGAP3 and Arfgap3

DIOPT Version :9

Sequence 1:	NP_001097664.2	Gene:	ArfGAP3 / 40487	FlyBaseID:	FBgn0037182	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_001344685.1	Gene:	Arfgap3 / 66251	MGIID:	1913501	Length:	525	Species:	Mus musculus

Alignment Length:	570	Identity:	216/570 - (37%)
Similarity:	297/570 - (52%)	Gaps:	74/570 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 PSKQEIESVFSRLRAQPANKSCFDCAAKAPTWSSVTYGIFICIDCSAVHRNLGVHLTFVRSTNLD 72
            ||||:|.::|.|||:.|.||.||||.||.|:|:|::||:|:|||||..||:|||||:|:|||.||
Mouse     4 PSKQDILAIFKRLRSVPTNKVCFDCGAKNPSWASISYGVFLCIDCSGSHRSLGVHLSFIRSTELD 68

  Fly    73 TNWTWLQLRQMQLGGNANAAQFFRAHNCSTTDAQVKYNSRAAQLYRDKLCAQAQQAMKTHGTKLH 137
            :||:|.|||.||:|||:||:.||..|.|:|.|...|||||||||||:|:...|.||.:.|||.|.
Mouse    69 SNWSWFQLRCMQVGGNSNASSFFHQHGCATKDTNAKYNSRAAQLYREKIKTLATQATRRHGTDLW 133

  Fly   138 LEQTDKSEGNEAAREEDFFAQCDNEVDFNVQNNNVSKQDPNPPTVAP---VISVETQQGG---AP 196
            |:.......:...:||||||   :.....|.....:...|...:..|   ..:.|..:||   .|
Mouse   134 LDSCAAPPVSPPPKEEDFFA---SHASLEVSGAMQASAQPESASSTPWGLETTPEKHEGGPGQGP 195

  Fly   197 SVNLLNS---VVPAAVPSSIGARKVQPKKGGLGARKVGGLGATKV-KTNFADIEARANAANEMKT 257
            ||..||:   ..||.|.|.|..:..|.|| ||||:| |.|||.|: .|:|.:||.:|.|.::.|.
Mouse   196 SVEGLNTPGKAAPAEVSSIIKKKPNQAKK-GLGAKK-GSLGAQKLTNTSFTEIEKQAQAVDKRKE 258

  Fly   258 SAAAAPVVKPQTAEDELETVASMRLAYQELSMQKTREEAKLKTMDPAKAKQMERLGMGFNLRGSD 322
            ....|     :.|..|...|:|:||||::|.:.:.::|.  ..:...|..:.|||||||....|.
Mouse   259 QEDLA-----RGAPKEESIVSSLRLAYKDLEISRKKDER--LNLSGQKKVEAERLGMGFGSCRSG 316

  Fly   323 MAHSALGDMETIQQS----AAPKAKLSLLESENFFTDFSLYGNSSSGGGGGGSSEKRESSVGGTS 383
            ::||...||:||:|.    |.|:.|......:::|:..|.:...||........|.|.||
Mouse   317 ISHSVTSDMQTIEQESPTLAKPRRKYQEDPEDSYFSSSSKWSEQSSSRYFDDPMELRSSS----- 376

  Fly   384 KLDKFELDALGYETIEPIGGSHSNITSMFSRSNDY---DKPKTSAPVKKNSGSSQTHTKGGT--- 442
                                    .:|....::.|   |..:...|..:::|||...:....
Mouse   377 ------------------------FSSWDDGADSYWKKDSSRDPEPAMRSTGSSDRPSARRKPEY 417

  Fly   443 ----STDPVIAQQKFGNSKGFGSDQYFASE-QSSADVSASLNRFQGSRAISSSDYFGDGSPGGTG 502
                |||.  ||:||||.|...||.||..: |:..:..|.|.|...|.:|||:|.|.:......|
Mouse   418 EPIGSTDE--AQKKFGNVKAISSDMYFGIQAQTDFETRARLERLSTSSSISSADLFDEQRKQTAG 480

  Fly   503 GNRASSVNFSAPDLDVESVKESVRQGVHKVAGRLSNLANDVMTSWQDKYG 552
            ....|:|..:|||:      ...:|||..|||:||..||.||||.||:||
Mouse   481 NYNLSNVLPNAPDM------AQFKQGVRSVAGKLSVFANGVMTSIQDRYG 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ArfGAP3	NP_001097664.2	ArfGap	17..121	CDD:214518	67/103 (65%)
Arfgap3	NP_001344685.1	ArfGap	13..116	CDD:214518	67/102 (66%)
		CDC27	<134..>292	CDD:312868	53/167 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	162..206		10/43 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	249..271		6/26 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	172	1.000	Domainoid score	I3716
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	328	1.000	Inparanoid score	I2442
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52037
OrthoDB	1	1.010	-	-		D1155557at2759
OrthoFinder	1	1.000	-	-		FOG0001852
OrthoInspector	1	1.000	-	-		otm42508
orthoMCL	1	0.900	-	-		OOG6_101784
Panther	1	1.100	-	-	LDO	PTHR45686
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R495
SonicParanoid	1	1.000	-	-		X1214
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.870