Protein Alignment ArfGAP3 and SMAP2

DIOPT Version :10

• Sequence 1: NP_001097664.2
• Gene: ArfGAP3 / 40487
• FlyBaseID: FBgn0037182
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: NP_073570.1
• Gene: SMAP2 / 64744
• HGNCID: 25082
• Length: 429
• Species: Homo sapiens
• Alignment Length: 445
• Identity: 107/445 - (24%)
• Similarity: 171/445 - (38%)
• Gaps: 104/445 - (23%)

  Fly     7 GPSKQEI---ESVFSRLRAQPANKSCFDCAAKAPTWSSVTYGIFICIDCSAVHRNLGVHLTFVRS 68
            |.|.:::   ::|.:.|..:..||.|.||.:|.|.|:|...|:||||.|:.:|||||||::.|:|
Human     3 GKSVKDVDRYQAVLANLLLEEDNKFCADCQSKGPRWASWNIGVFICIRCAGIHRNLGVHISRVKS 67

  Fly    69 TNLDTNWTWLQLRQMQLGGNANAAQFFRAHNCSTTDAQVKYNSRAAQLYRDKLCAQAQQAMKTHG 133
            .||| .||..|::.||..||..|.:.:.|: ...|..:.:.:.......|||...:.........
Human    68 VNLD-QWTQEQIQCMQEMGNGKANRLYEAY-LPETFRRPQIDPAVEGFIRDKYEKKKYMDRSLDI 130

  Fly   134 TKLHLEQTDK-SEGNEAAREEDFFAQCDNEVDFNVQNNNVSKQDP------NPPTVAPVISV--- 188
            .....|:.|| ..|:|...|:..     ..|.|........|:||      :|.:.|||:.:
Human   131 NAFRKEKDDKWKRGSEPVPEKKL-----EPVVFEKVKMPQKKEDPQLPRKSSPKSTAPVMDLLGL 190

  Fly   189 -----------ETQQGGAPSVNLLNSVVPAAVPSSIGARKV---QPKKGGLGA------------ 227
                       :|.......::||.| ||:  |||.|:|||   .|..|..|:
Human   191 DAPVACSIANSKTSNTLEKDLDLLAS-VPS--PSSSGSRKVVGSMPTAGSAGSVPENLNLFPEPG 252

  Fly   228 RKVGGLGATKVKTNFADIEARANAANEMKTSA---AAAPVVKPQTAEDELETVASMRLAYQELSM 289
            .|...:|..::..: :.:....:...:|.|.|   |.|.:..| ||......|
Human   253 SKSEEIGKKQLSKD-SILSLYGSQTPQMPTQAMFMAPAQMAYP-TAYPSFPGV------------ 303

  Fly   290 QKTREEAKLKTMDPAKAKQMERLGMGFNLRGSDMAHSALGDME-----------TIQQ------- 336
              |...:.:.:|.|.....:.:.|....:....|....:|.|:           |.||
Human   304 --TPPNSIMGSMMPPPVGMVAQPGASGMVAPMAMPAGYMGGMQASMMGVPNGMMTTQQAGYMAGM 366

  Fly   337 SAAPKAKLSLLESE----------------NFF--TDFSLYGNSSSGGGGGGSSE 373
            :|.|:....:..::                ||:  .....||.|.|||.|..:::
Human   367 AAMPQTVYGVQPAQQLQWNLTQMTQQMAGMNFYGANGMMNYGQSMSGGNGQAANQ 421

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ArfGAP3	NP_001097664.2	ArfGap_ArfGap2_3_like	12..127	CDD:350060	42/117 (36%)
SMAP2	NP_073570.1	ArfGap_SMAP2	16..122	CDD:350083	41/107 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	138..184		12/50 (24%)
		Interaction with clathrin heavy chains. /evidence=ECO:0000250	163..232		20/71 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	217..259		13/43 (30%)
		Interaction with PICALM. /evidence=ECO:0000250	340..429		16/82 (20%)