DRSC/TRiP Functional Genomics Resources

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Protein Alignment ArfGAP3 and ARAP3

DIOPT Version :9

Sequence 1:NP_001097664.2 Gene:ArfGAP3 / 40487 FlyBaseID:FBgn0037182 Length:553 Species:Drosophila melanogaster
Sequence 2:NP_071926.4 Gene:ARAP3 / 64411 HGNCID:24097 Length:1544 Species:Homo sapiens


Alignment Length:546 Identity:115/546 - (21%)
Similarity:184/546 - (33%) Gaps:178/546 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 VFSRLRAQPANKSCFDCAAKAPTWSSVTYGIFICIDCSAVHRNLGVHLTFVRSTNLDTN-WTWLQ 79
            |..::.:..||:.|.||.:..|.|::|..|:.||..|:..||.||..::.|:|..|||: |:...
Human   491 VAEKIWSNRANRQCADCGSSRPDWAAVNLGVVICKQCAGQHRALGSGISKVQSLKLDTSVWSNEI 555

  Fly    80 LRQMQLGGNANAAQFFRA--------HNCSTTDAQVKYNSRAAQL---------YRDK------- 120
            ::...:.||..|.:|:..        |..:|...:.::.||..:|         |.|.       
Human   556 VQLFIVLGNDRANRFWAGTLPPGEGLHPDATPGPRGEFISRKYRLGLFRKPHPQYPDHSQLLQAL 620

  Fly   121 ----------------LCAQAQQAMK------THGTKLHLEQTDKSEG--NEAAREEDF--FAQC 159
                            ||.:|.:..:      ..|:...|..:|.|.|  ||......:  |..|
Human   621 CAAVARPNLLKNMTQLLCVEAFEGEEPWFPPAPDGSCPGLLPSDPSPGVYNEVVVRATYSGFLYC 685

  Fly   160 DNEVDFNVQNNNVSKQDPNPP---TVAP-----VISVETQQGGAPSVNLLNSVVPAAV--PSSIG 214
            .     .|.|    |..|:||   ..||     |:....:...:.     ||..|.::  |..|.
Human   686 S-----PVSN----KAGPSPPRRGRDAPPRLWCVLGAALEMFASE-----NSPEPLSLIQPQDIV 736

  Fly   215 ARKVQPKKGGLGAR--------KVGGLGATKVK---TNFAD-IEARANAANEMKTSAAAAPVVKP 267
            ...|.|.....|.|        ..||    :::   |:.|| :||..:|..:..:..:...::.|
Human   737 CLGVSPPPTDPGDRFPFSFELILAGG----RIQHFGTDGADSLEAWTSAVGKWFSPLSCHQLLGP 797

  Fly   268 QTAEDELETVASMRLAYQELSMQKTREEAKLKTMDPAKAKQMERLGMGFNLRG------------ 320
                      ..:||.  .|.::.....|      ||....:...|:   |||            
Human   798 ----------GLLRLG--RLWLRSPSHTA------PAPGLWLSGFGL---LRGDHLFLCSAPGPG 841

  Fly   321 ----SDMAH-SALGDMETIQQSAAPKAKLSLLESENFFT---------DFSLYGNSSSGGGGGGS 371
                .||.| ..|.::..:..:..|..|..|:..|...|         ||:.:..:..|..|||.
Human   842 PPAPEDMVHLRRLQEISVVSAADTPDKKEHLVLVETGRTLYLQGEGRLDFTAWNAAIGGAAGGGG 906

  Fly   372 SEKRESSV-----------------------------GGTSK-----LDKFELDALGYETIEPIG 402
            :..:|..:                             ||...     |.:|..||...: :.|  
Human   907 TGLQEQQMSRGDIPIIVDACISFVTQHGLRLEGVYRKGGARARSLRLLAEFRRDARSVK-LRP-- 968

  Fly   403 GSH--SNITSMFSR-SNDYDKPKTSA 425
            |.|  .::|....| ..:.|.|.|||
Human   969 GEHFVEDVTDTLKRFFRELDDPVTSA 994

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ArfGAP3NP_001097664.2 ArfGap 17..121 CDD:214518 33/144 (23%)
ARAP3NP_071926.4 SAM_Arap1,2,3 4..66 CDD:188889
SAM 12..64 CDD:197735
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 64..147
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 167..194
PH 288..379 CDD:278594
PH1_ARAP 289..381 CDD:270073
PH2_ARAP 398..479 CDD:270074
PH 399..482 CDD:278594
ArfGap 490..606 CDD:279720 32/114 (28%)
PH3_ARAP 676..786 CDD:270076 28/127 (22%)
PH-like <846..894 CDD:302622 11/47 (23%)
RhoGAP_ARAP 909..1084 CDD:239850 17/89 (19%)
RA 1117..1209 CDD:279168
PH5_ARAP 1212..1331 CDD:270079
PH 1241..1325 CDD:278594
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1422..1544
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5347
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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