DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ArfGAP3 and asap2b

DIOPT Version :9

Sequence 1:	NP_001097664.2	Gene:	ArfGAP3 / 40487	FlyBaseID:	FBgn0037182	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_001038398.2	Gene:	asap2b / 560581	ZFINID:	ZDB-GENE-030131-5060	Length:	1024	Species:	Danio rerio

Alignment Length:	415	Identity:	85/415 - (20%)
Similarity:	133/415 - (32%)	Gaps:	147/415 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 ESVFSRLRAQPANKSCFDCAAKAPTWSSVTYGIFICIDCSAVHRNLGVHLTFVRSTNLDTNWTWL 78
            :::...::....|..|.||.|..|||.|...|:.|||:||.:||.:|||.:.::|..||...|..
Zfish   421 KAIVGEVKKMSGNDVCCDCGASNPTWLSTNLGVLICIECSGIHREMGVHYSRIQSLTLDLLGTSE 485

  Fly    79 QLRQMQLGGNANAA--------------------------QFFRAHNCSTTDAQVKYNSRAAQLY 117
            .|....:|   |||                          .|..|.......||.||...||:|:
Zfish   486 LLLANSVG---NAAFNEIMEAKLSSEIPKPNPSSDMQVRKDFITAKYTEKRFAQKKYADNAARLH 547

  Fly   118 --------RD-----KLCAQAQQAMKTHGTKLHLEQTDKSEGNE-----AAREEDFFAQCDNEVD 164
                    ||     ::.|:....|:|      :.|.::.|..|     |.|..|  ....:.||
Zfish   548 ALCDAVKSRDIFSLIQVYAEGLDLMET------INQPNQHEPGETSLHLAVRMVD--RNSLHIVD 604

  Fly   165 FNVQNN-NVSKQDPNPPTVAPVISVETQQ-------GGAPSVNLLNSVVPAAVPSSIGARKVQPK 221
            |.|||: |:.||.....|......:....       .|..||::.|.....|:
Zfish   605 FLVQNSGNLDKQTAKGSTALHYCCLTDNSECMKLLLRGKASVSITNDAGETAL------------ 657

  Fly   222 KGGLGARKVGGLGATKVKTNFADIEARANAANEMKTSAAAAPVVKPQT----------------- 269
                                        :.|..:|.|.....:.:.||
Zfish   658 ----------------------------DLAQRLKHSKCEELLTQAQTGKFNVHVHVEYDWRLHN 694

  Fly   270 -----AEDELETVASMRLAYQELSMQKTREEAKLKTMDPAKAKQMERLGMGFNLRGSDMAHSALG 329
                 :|||:|          :..:...|||..:..:.|.....|..:        |.:|.....
Zfish   695 EDLDESEDEME----------DKPIPIRREERPISCIVPGSGPMMPNM--------SALARDVAN 741

  Fly   330 DMETIQQSAAPKAKLSLLESENFFT 354
            .:...|::..|    |::.:|.:.|
Zfish   742 VVNNKQRAFIP----SMMMNETYGT 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ArfGAP3	NP_001097664.2	ArfGap	17..121	CDD:214518	40/142 (28%)
asap2b	NP_001038398.2	BAR	34..248	CDD:299863
		PH_ASAP	297..403	CDD:270071
		PH	306..393	CDD:278594
		ArfGap	421..537	CDD:279720	32/118 (27%)
		ANK repeat	548..579	CDD:293786	6/36 (17%)
		ANK	<575..672	CDD:238125	24/138 (17%)
		Ank_5	<584..626	CDD:290568	14/43 (33%)
		ANK repeat	584..617	CDD:293786	12/34 (35%)
		Ank_5	606..660	CDD:290568	12/93 (13%)
		ANK repeat	619..650	CDD:293786	4/30 (13%)
		SH3_ASAP2	966..1021	CDD:212899
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810