Protein Alignment ArfGAP3 and ARFGAP1

DIOPT Version :10

• Sequence 1: NP_001097664.2
• Gene: ArfGAP3 / 40487
• FlyBaseID: FBgn0037182
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: XP_011527203.1
• Gene: ARFGAP1 / 55738
• HGNCID: 15852
• Length: 416
• Species: Homo sapiens
• Alignment Length: 553
• Identity: 135/553 - (24%)
• Similarity: 195/553 - (35%)
• Gaps: 200/553 - (36%)

  Fly     1 MASPAAGPSKQEIESVFSRLRAQPANKSCFDCAAKAPTWSSVTYGIFICIDCSAVHRNLGVHLTF 65
            ||||       ....|...:|.|..|..||:|.|..|.|.||||||:||::||..||.|||||:|
Human     1 MASP-------RTRKVLKEVRVQDENNVCFECGAFNPQWVSVTYGIWICLECSGRHRGLGVHLSF 58

  Fly    66 VRSTNLDTNWTWLQLRQMQLGGNANAAQFFRAHN----CSTTDAQVKYNSRAAQLYRDKLCAQAQ 126
            |||..:| .|..::|.:|:.||||...:|..:..    |  ...|.|||||||.|:|||:.|.|
Human    59 VRSVTMD-KWKDIELEKMKAGGNAKFREFLESQEDYDPC--WSLQEKYNSRAAALFRDKVVALA- 119

  Fly   127 QAMKTHGTKLHLEQTDKSEGNEAAREEDFFAQCDNEVDFNVQNNNVSKQDPNPPTVAPVISVETQ 191
                              ||.|                ::::::......|..|...|  |:..:
Human   120 ------------------EGRE----------------WSLESSPAQNWTPPQPRTLP--SMVHR 148

  Fly   192 QGGAPSVNLLNSVVPAA-------VPSSIGARKVQPKKGGLGARKVGGLGATKVKTNFADIEARA 249
            ..|.|     .||..::       :...:|:     .:|..|.|.| |.|.|.
Human   149 VSGQP-----QSVTASSDKAFEDWLNDDLGS-----YQGAQGNRYV-GFGNTP------------ 190

  Fly   250 NAANEMKTSAAAAPVVKPQTAEDEL--ETVASMRLAYQELSMQKTREEAKLKTMDPAKAKQMERL 312
                            .||..||:.  ..::|:...:...:...:|..:..|........|..:.
Human   191 ----------------PPQKKEDDFLNNAMSSLYSGWSSFTTGASRFASAAKEGATKFGSQASQK 239

  Fly   313 GMGFNLR---GSDMAHSALGDMETIQQSAAPKAKLSLLESENFFTDFSLYGNSSSGGG------- 367
            ..|...:   .|::.||.   .|.:.:.|..|.|           :..::.:.|||..
Human   240 FWGHKQQPEPASELGHSL---NENVLKPAQEKVK-----------EGKIFDDVSSGVSQLASKVQ 290

  Fly   368 GGGS----------SEKRESSVGGTSK--------LDKFELDALGYETIEPIGGSHSNITSMFSR 414
            |.||          |.|.|..:...|:        ||.|:               :|||...|
Human   291 GVGSKGWRDVTTFFSGKAEGPLDSPSEGHSYQNSGLDHFQ---------------NSNIDQSF-- 338

  Fly   415 SNDYDKPKTSAPVK-KNSGSSQTHTKGGTSTDPVIAQQKFGNSKGFGSDQYFASEQSSADV---- 474
               ::...::.|.| :.|.||.:.|...|||                       |:.|:|.
Human   339 ---WETFGSAEPTKTRKSPSSDSWTCADTST-----------------------ERRSSDSWEVW 377

  Fly   475 -SASLNRFQGSRAISSSDYFGDGSPGGTGGNRA 506
             |||.||...|          ||..||.|..:|
Human   378 GSASTNRNSNS----------DGGEGGEGTKKA 400

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ArfGAP3	NP_001097664.2	ArfGap_ArfGap2_3_like	12..127	CDD:350060	55/118 (47%)
ARFGAP1	XP_011527203.1	ArfGap_ArfGap1	6..121	CDD:350059	55/136 (40%)